Cardiovascular Genetics and Genomics: Principles and Clinical Practice

Front Matter ....Pages i-xix
 Introduction to Genes, Genome and Inheritance  (Dhavendra Kumar)....Pages 1-34
 Spectrum and Classification of Inherited Cardiovascular Disease  (Paul Brennan)....Pages 35-69
 Principles and Practice of Genetic Counselling for Inherited Cardiac Conditions  (Sharon Jenkins, Caroline Kirwan)....Pages 71-95
 Genetic and Genomic Technologies: Next Generation Sequencing for Inherited Cardiovascular Conditions  (Lorenzo Monserrat)....Pages 97-117
 Pharmacogenetics and Pharmacogenomics in Cardiovascular Medicine and Surgery  (Richard Myles Turner, Sir Munir Pirmohamed)....Pages 119-172
 Congenital Cardiovascular Disorders  (Dirk G. Wilson)....Pages 173-188
 Inherited Cardiovascular Metabolic Disorders  (Elaine Murphy, Oliver Watkinson)....Pages 189-237
 Mitochondrial Cardiovascular Diseases  (Michael J. Keogh, Hannah E. Steele, Patrick F. Chinnery)....Pages 239-258
 Inherited Cardiac Muscle Disorders: Hypertrophic and Restrictive Cardiomyopathies  (Mohammed Majid Akhtar, Juan Pablo Kaski, Perry Elliott)....Pages 259-317
 Inherited Cardiac Muscle Disease: Dilated Cardiomyopathy  (Eloisa Arbustini, Lorenzo Giuliani, Alessandro Di Toro, Valentina Favalli)....Pages 319-366
 Inherited Cardiac Muscle Disorders: Arrhythmogenic Right Ventricular Cardiomyopathy  (Kalliopi Pilichou, Barbara Bauce, Gaetano Thiene, Cristina Basso)....Pages 367-388
 Inherited Cardiac Muscle Disorders: Left Ventricular Noncompaction  (James Marangou, Michael Frenneaux, Girish Dwivedi)....Pages 389-412
 Inherited Arrhythmias: LQTS/SQTS/CPVT  (Andrea Mazzanti, Silvia G. Priori)....Pages 413-435
 Inherited Arrhythmias: Brugada Syndrome and Early Repolarisation Syndrome  (Pieter G. Postema, Krystien V. V. Lieve, Arthur A. M. Wilde)....Pages 437-480
 Inherited Conduction Disease and Atrial Fibrillation  (Claire Martin, Pier Lambiase)....Pages 481-522
 Cardiovascular Manifestations in Duchenne/Becker Muscular Dystrophy and Other Primary Myopathies  (Douglas A. Stoller, Pradeep P. A. Mammen)....Pages 523-543
 Familial Cardiac Amyloidoses  (Claudio Rapezzi, Christian Gagliardi, Fabrizio Salvi, Ilaria Bartolomei, Candida Cristina Quarta, Agnese Milandri)....Pages 545-577
 Cardiovascular Manifestations of Myotonic Dystrophy  (Umesh Vivekananda, Michael Hanna, Chris Turner)....Pages 579-587
 Marfan Syndrome and Related Disorders  (John C. S. Dean, Bart Loeys)....Pages 589-615
 Cardiovascular Manifestations in Inherited Connective Tissue Disorders  (Julie de Backer, Anne de Paepe)....Pages 617-646
 Thoracic Aortic Dilatation, Aneurysm and Dissection  (Michael Ibrahim, Nimesh D. Desai)....Pages 647-660
 Genetics and Genomics of Coronary Artery Disease  (Yoshiji Yamada, Yoshiki Yasukochi)....Pages 661-678
 Cardiovascular Manifestations of Immune-Mediated Inflammatory Disorders  (Anna Abou-Raya, Suzan Abou-Raya)....Pages 679-693
 Genetics and Genomics of Stroke  (Rhea Y. Y. Tan, Hugh S. Markus)....Pages 695-722
 Genetics and Genomics of Systemic Hypertension  (Patricia B. Munroe, Syeda N. S. Jahangir, Mark J. Caulfield)....Pages 723-740
 Inherited Pulmonary Arterial Hypertension  (Sophie Herbert, Robert M. R. Tulloh)....Pages 741-753
 Genetics and Genomics of Sudden Unexplained Cardiac Death  (Efstathios Papatheodorou, Mary N. Sheppard, Elijah R. Behr)....Pages 755-779
 Specific Issues in Clinical Genetics and Genetic Counselling Practices Related to Inherited Cardiovascular Conditions  (Angus Clarke, Siv Fokstuen)....Pages 781-815
 Multi-Disciplinary Management of Inherited Cardiovascular Conditions  (Gerry Carr-White, Robert Leema)....Pages 817-838
 Interventions and Implantable Devices for Inherited Cardiac Conditions  (Zaheer Yousef, Mark Drury-Smith)....Pages 839-867
 Inherited Cardiovascular Conditions: Phenotype-Genotype Data Mining and Sharing, and Databases  (J. Peter van Tintelen, Paul A. van der Zwaag)....Pages 869-877
Back Matter ....Pages 879-920