Cardiovascular Effects of Dihydropyridine-Type Calcium Antagonists and Agonists

Front Matter....Pages I-XIII
Welcome....Pages 1-2
Calcium Antagonists and Calcium Agonists: Fundamental Criteria and Classification....Pages 3-31
Front Matter....Pages 33-33
Mechanism of Calcium Channel Modulation by Dihydropyridine Agonists and Antagonists....Pages 34-57
Ca Entry into Vascular Smooth Muscle....Pages 58-73
Calcium Currents in Mammalian Central Neurones....Pages 74-88
Front Matter....Pages 89-89
Chemistry of Dihydropyridines [1–4]....Pages 90-103
Structure-Function Relationships of 1,4-Dihydropyridines: Ligand and Receptor Perspectives....Pages 104-112
Calcium Channels: Introduction into Their Molecular Pharmacology....Pages 113-139
The Dihydropyridine Receptors....Pages 140-155
A Proposed Pharmacological Role for Dihydropyridine Binding Sites in Heart and Coronary Smooth Muscle....Pages 156-186
Front Matter....Pages 187-187
The Effects of 1,4-Dihydropyridine Type Ca 2+ -Channel Antagonists and Agonists on Intracellular [Ca 2+ ) Transients Accompanying Twitch Contraction of Heart Muscle....Pages 188-197
Voltage-Dependent Modulation of Cardiac Ca-Channels by Dihydropyridines....Pages 198-217
Effects of the Calcium Agonistic Dihydropyridine Bay K 8644 on the Heart....Pages 218-235
Myocardial Effects of Dihydropyridines in Patients....Pages 236-250
Front Matter....Pages 251-251
Effect of Dihydropyridines on Visceral Smooth Muscle....Pages 252-258
Effects of Ca 2+ Antagonists on Isolated Rabbit Mesenteric Resistance Vessels as Compared to Rabbit Aorta....Pages 259-271
Effect of Dihydropyridine Calcium Channel Modulators on Isolated Peripheral and Cerebral Vessels....Pages 272-289
Effects of Ca ++ -Agonistic and Ca ++ -Antagonistic 1,4-Dihydropyridine Compounds on Tonic and Phasic Activation of Extramural Coronary Vasculature....Pages 290-308
Effects of Dihydropyridines on Human and Animal Isolated Vessels....Pages 309-326
Endothelium-Dependent Vascular Relaxation....Pages 327-335
Front Matter....Pages 337-337
Coronary and Systemic Hemodynamic Effects of Dihydropyridines....Pages 338-352
Effect of a Dihydropyridine-Type Calcium Antagonist on Cerebral Blood Flow and Metabolism....Pages 353-361
Calcium, Dihydropyridines and Resistance Vessel Tone....Pages 362-369
Differences Between Dihydropyridine and Non-Dihydropyridine Calcium Antagonists in Inotropic, Chronotropic, Dromotropic and Vascular Effects: Differences in Underlying Mechanism....Pages 370-380
Effects of Calcium Antagonists on Fixed and Dynamic Obstructions in Patients with Severe Coronary Artery Disease....Pages 381-409
Front Matter....Pages 411-411
Effects of Calcium Antagonistic and Agonistic Dihydropyridines on Experimental Hypertension and Vascular Damage....Pages 412-422
On the Antihypertensive Properties of Nitrendipine, with Observations of Its Effects on Electrolyte Excretion....Pages 423-436
The Use of Calcium Antagonists in the Treatment of Arterial Hypertension....Pages 437-444
Calcium Antagonists for Identification of Mechanisms and Treatment in Patients with Essential Hypertension....Pages 445-457
Front Matter....Pages 459-459
Dihydropyridines and the Protection of the Ischaemic and Anoxic Myocardium....Pages 460-473
Protection Against Complete Cerebral Ischemia by Nimodipine....Pages 474-479
Interdependence of Antihypertensive, Anticalcinotic, and Antiarteriosclerotic Effects of Calcium Antagonists — Model Experiments on Spontaneously Hypertensive Rats (SHR)....Pages 480-502
Back Matter....Pages 503-511