Cardiomyopathies and Heart Failure: Biomolecular, Infectious and Immune Mechanisms

Front Matter....Pages i-xxi
Front Matter....Pages 1-1
Cardiomyopathies and Heart Failure....Pages 1-15
Front Matter....Pages 17-17
Chemokines and Cardiovascular Diseases....Pages 17-25
Negative Regulator of Cytokine Signaling (SOCS) Genes in Inflammation....Pages 27-38
The Interleukin-6 Family of Cytokines and their Receptors in Patients with Congestive Heart Failure....Pages 39-46
Animal Model of Cardiomyopathy Due to Overexpression of TNF-α....Pages 47-58
Front Matter....Pages 59-59
Myosin Autoreactive T Cells And Autoimmune Myocarditis. Lessons from the Disease Caused by Cardiac Myosin Peptide CM2....Pages 59-65
Autoimmunity in Cardiomyopathies....Pages 67-81
Anti-G-Protein-Coupled Cardiac Receptor Autoantibodies in Dilated Cardiomyopathy....Pages 83-96
Clinical Significance of Circulating Cardiac Autoantibodies in Dilated Cardiomyopathy and Myocarditis....Pages 97-109
Front Matter....Pages 111-111
Development of Mast Cells: Process and Regulatory Mechanisms....Pages 111-120
Mast Cells in Experimental Myocardial Infarction....Pages 121-132
Possible Involvement of Mast Cells in the Development of Fibrosis....Pages 133-144
Human Mast Cell Chymase and 31 Amino Acid Endothelin-1....Pages 145-158
Tryptase From Human Mast Cells....Pages 159-172
Effects of the Tryptase Receptor Activating Peptide and Antibodies Against the Tryptase Receptor Par-2 on Neonatal Rat Cardiomyocytes in Culture....Pages 173-184
Front Matter....Pages 185-185
Role of Human Heart Mast Cells in Immunologic and Inflammatory Mechanisms Underlying Cardiovascular Disorders....Pages 185-198
Mast Cells in Atherosclerotic Human Coronary Arteries: Implications for Coronary Fatty Streak Formation and Plaque Erosion or Rupture....Pages 199-212
The Key Role of Mast Cells in the Evolution to Congestive Heart Failure....Pages 213-228
Front Matter....Pages 229-229
Links Between Viral Infections and Heart Disease....Pages 229-243
Molecular Detection and Characterization of Human Enteroviruses....Pages 245-257
Front Matter....Pages 229-229
Detection and Biological Implications of Genetic Memory in Viral Quasispecies....Pages 259-276
The Group B Coxsackieviruses as Vaccines and Vectors....Pages 277-290
Detection of Important Diagnostic Markers of HCV Infection....Pages 291-299
Front Matter....Pages 301-301
Large Animal Model of Viral Myocarditis....Pages 301-324
Hepatitis Cvirus and Cardiomyopathy....Pages 325-339
Diagnosis and Treatment of Myocarditis: The Role of Adenovirus Infection in Cardiomyopathy and Heart Failure....Pages 341-355
The Natural History of Viral Myocarditis: Pathogenetic Role of Adrenergic System Dysfunction in the Development of Idiopathic Dilated Cardiomyopathy....Pages 357-372
Clinical Diagnosis of Myocarditis....Pages 373-388
Recent Advances in Giant Cell Myocarditis....Pages 389-400
Registry of Myocarditis and Heart Failure....Pages 401-414
Front Matter....Pages 415-415
Molecular Etiology of Idiopathic Cardiomyopathy....Pages 415-428
Gene-Based Therapy of Long QT Syndrome....Pages 429-438
Front Matter....Pages 439-439
How Does Adenosine Mediate Cardioprotection?....Pages 439-455
Protection of Cell Injury by Thioredoxin....Pages 457-468
Hematopoietic Stem Cells and Angiogenesis....Pages 469-480
Transplanting Cells for the Treatment of Cardiomyopathy....Pages 481-489
Toward an Ideal Large Animal Model of Dilated Cardiomyopathy to Study Left Ventricular Volume Reduction Surgery....Pages 491-501
Heart Transplantation: 35 Years of Progress....Pages 503-514
Genes of the Major Histocompability Complex Class II Influence the Phenotype of Cardiomyopathies Associated With Hepatitis C Virus Infection....Pages 515-521
Back Matter....Pages 523-531