Cardiac Remodeling: Molecular Mechanisms

Front Matter....Pages i-xi
Front Matter....Pages 1-1
β-Adrenergic Receptor Signaling in Heart Failure....Pages 3-30
Remodeling of Potassium Channels in Cardiac Hypertrophy....Pages 31-45
Role of Gender in Ca 2+ Cycling and Cardiac Remodeling Due to Heart Failure....Pages 47-64
The Failing Heart: Is It an Inefficient Engine or an Engine Out of Fuel?....Pages 65-84
Regulation of Cardiac Hypertrophic Remodeling by the USP15/SLIM1 Pathway....Pages 85-96
Role of Galectin-3 Pathways in the Pathogenesis of Cardiac Remodeling and Heart Failure....Pages 97-111
A Mitochondriocentric Pathway to Cardiomyocyte Necrosis: An Upstream Molecular Mechanism in Myocardial Fibrosis....Pages 113-125
The ACE2/Ang (1–7) Pathway in Cardiac Remodeling Due to Pressure Overload....Pages 127-139
Local Actions of Natriuretic Peptides and Nitric Oxide in Cardiac Remodeling: Implications for Therapy....Pages 141-158
Modulating G Protein-Coupled Receptors to Effect Reverse Cardiac Remodeling....Pages 159-177
Role of Inflammation and Matrix Proteinases in Cardiac Remodeling Following Stress and Injury....Pages 179-200
Role of Chymase in Matrix and Myocardial Remodeling Due to Mitral Regurgitation: Implications for Therapy....Pages 201-214
Cardiac Remodeling Due to Aortic Regurgitation and Mitral Regurgitation....Pages 215-226
Reducing Oxidative Stress and Manipulating Molecular Signaling Events Using Resveratrol as a Therapy for Pathological Cardiac Hypertrophy....Pages 227-254
Angiogenesis, Arteriogenesis, and Mitochondrial Dysfunction....Pages 255-272
Front Matter....Pages 273-273
Subcellular Remodeling and Cardiac Dysfunction Due to Ischemia–Reperfusion Injury....Pages 275-291
Role of MicroRNAs in Cardiac Hypertrophy and Postinfarction Remodeling....Pages 293-311
Negative Regulators of Inflammation as Endogenous Protective Mechanisms in Postinfarction Remodeling....Pages 313-330
TLR-Dependent Pathways and Akt/mTOR/P70S6K Pathways in Cardiac Remodeling After Myocardial Infarction....Pages 331-345
The STAT3 Pathway and Downstream Mechanisms in Cardiac Remodeling: Friend or Foe....Pages 347-364
Front Matter....Pages 273-273
The Role of Growth Differentiation Factor 5 in Cardiac Repair Post-Myocardial Infarction....Pages 365-382
Extracellular Matrix Biomarkers of Adverse Remodeling After Myocardial Infarction....Pages 383-412
Oxidative Stress in Cardiac Repair and Remodeling: Molecular Pathways and Therapeutic Strategies....Pages 413-425
Role of SPARC in Cardiac Extracellular Matrix Remodeling After Myocardial Infarction....Pages 427-444
Tissue Inhibitor of Matrix Metalloproteinases in the Pathogenesis of Heart Failure Syndromes....Pages 445-465
Intracellular Matrix Remodeling and Cardiac Function in Ischemia–Reperfusion Injury....Pages 467-485
Aging and Markers of Adverse Remodeling After Myocardial Infarction....Pages 487-512
Optimizing Stem Cell Therapy for Cardiac Repair Following a Myocardial Infarction....Pages 513-524
Regulation of Fibrosis After Myocardial Infarction: Implications for Ventricular Remodeling....Pages 525-545
The ACE2/Ang-(1–7) Pathway in Cardiac Fibroblasts as a Potential Target for Cardiac Remodeling....Pages 547-557
Back Matter....Pages 559-569