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دانلود کتاب Cancer Pharmacology: An Illustrated Manual of Anticancer Drugs
دانلود کتاب فارماکولوژی سرطان: کتابچه راهنمای مصور داروهای ضد سرطان
مشخصات کتاب
Cancer Pharmacology: An Illustrated Manual of Anticancer Drugs
ویرایش: [1 ed.] نویسندگان: Judith E. Karp (editor), Candace B. Mainor (editor), Ashkan Emadi (editor) سری: ISBN (شابک) : 0826162037, 9780826162038 ناشر: Demos Medical Publishing سال نشر: 2019 تعداد صفحات: 304 [313] زبان: English فرمت فایل : PDF (درصورت درخواست کاربر به PDF، EPUB یا AZW3 تبدیل می شود) حجم فایل: 15 Mb
قیمت کتاب (تومان) : 51,000
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توجه داشته باشید کتاب فارماکولوژی سرطان: کتابچه راهنمای مصور داروهای ضد سرطان نسخه زبان اصلی می باشد و کتاب ترجمه شده به فارسی نمی باشد. وبسایت اینترنشنال لایبرری ارائه دهنده کتاب های زبان اصلی می باشد و هیچ گونه کتاب ترجمه شده یا نوشته شده به فارسی را ارائه نمی دهد.
توضیحاتی در مورد کتاب فارماکولوژی سرطان: کتابچه راهنمای مصور داروهای ضد سرطان
\"ما در زمان هیجان انگیزی برای فارماکولوژی سرطان زندگی می کنیم، جایی که ادغام چندین رشته علوم پایه و بالینی در حال ایجاد درمان های موثر و طولانی مدت برای تعداد فزاینده ای از بدخیمی ها هستند. از نظر تاریخی، اولین عوامل ضد سرطانی مولکول های حیاتی را مورد هدف قرار دادند. به فرآیند کلی تکثیر سلولی در سلول‌های نرمال و بدخیم و به همین ترتیب، در سمیت سلولی آنها نسبتاً تبعیض‌آمیز نبودند. طراحی عواملی که به طور انتخابی جهش‌های ژنی مرتبط با تومور و واسطه‌های مسیر سیگنالینگ را هدف قرار می‌دهند، به گونه‌ای که ممکن است مرگ سلولی تومور را افزایش داده و از جمعیت‌های سلولی نرمال در زیرین محافظت کند.
توضیحاتی درمورد کتاب به خارجی
\"We are living in an exciting time for cancer pharmacology, where the fusion of multiple disciplines of basic and clinical science are creating effective, life-prolonging therapies for a growing number of malignancies. Historically, the first anticancer agents targeted molecules that are critical to the overall process of cell replications in both normal and malignant cells and, as such, were relatively non-discriminatory in their cytotoxicity. The revolution in molecular technology that began in the late 1980\'s is now being brought to bear on the structural design of agents that selectively target tumor-related gene mutations and signaling pathway intermediaries in ways that may augment tumor cell death and spare underlying normal cell populations\"--
فهرست مطالب
Cover Title Copyright Contents Contributors Preface Chapter 1: Anticancer Drug Development: An Introduction Introduction Pathophysiology of Cancer, Where Cancer Drugs Come From How Do We Know a Cancer Drug Might Be Useful? Why Do Cancer Drugs Work at All, Stop Working, or Never Work? Pharmacokinetics: Action of the Host on an Administered Drug Limitations to Effective Drug Action Chapter Summary Clinical Pearls Multiple Choice Questions Answers to Multiple choice Questions Selected References Chapter 2: Alkylating Agents Introduction Nitrogen Mustards Nitrosoureas Triazines Ethylenimines Platinum Compounds Chapter Summary Clinical Pearls Multiple Choice Questions Answers to Multiple Choice Questions Selected References Chapter 3: Antimetabolites: Hydroxyurea, Pyrimidine and Purine Analogs, and L-Asparaginase Introduction Ribonucleotide Reductase Inhibition Asparaginase Chapter Summary Clinical Pearls Multiple Choice Questions Answers to Multiple Choice Questions Selected References Chapter 4: Antimetabolites: Antifolates Introduction Role of Folic Acid in Metabolism Antifolates and Their Mechanism of Action Folate Transporters Intracellular Metabolism of Folate and Antifolates Absorption and Elimination of Antifolates Antifolate Adverse Events Toxicity and Rescue with High-Dose Methotrexate Regimens Chapter Summary Clinical Pearls Multiple Choice Questions Answers to Multiple Choice Questions Selected References Chapter 5: Antimitotics Introduction Vinca Alkaloids Taxanes Newer Microtubule-Directed Agents Chapter Summary Clinical Pearls Multiple Choice Questions Answers to Multiple Choice Questions Selected References Chapter 6: DNA Repair, Apoptotic Pathways, CDK Inhibitors Introduction Topoisomerases: Endogenous Enzymes That Become Agents of DNA Damage Targeting the DNA Damage Response Activating Apoptosis: BH3 Mimetics and Beyond CDK Inhibitors: Targeting the Cell Cycle, Antiapoptotic Proteins, and More Chapter Summary Clinical Pearls Multiple Choice Questions Answers to Multiple Choice Questions Selected References Chapter 7: Epigenetic Modulators Introduction Bromodomain Inhibitors Chapter Summary Clinical Pearls Multiple Choice Questions Answers to Multiple Choice Questions Selected References Chapter 8: Differentiating Agents and Microenvironment Introduction Chapter Summary Clinical Pearls Multiple Choice Questions Answers to Multiple Choice Questions Selected References Chapter 9: Hormonal Therapies Alone and in Combinations for Treatment of Breast Cancer Introduction Dedication Estrogen Receptor in Breast Cancer Selective Estrogen Receptor Modulators Aromatase Inhibitors AIs in Combination with Kinase Inhibitors Selective Estrogen Receptor Degraders Ovarian Suppression Chapter Summary Clinical Pearls Multiple Choice Questions Answers to Multiple Choice Questions Selected References Chapter 10: Male Hormonal Therapies Introduction Prostate Cancer and Androgens Biosynthesis Androgen Receptor Biology and Signaling in Prostate Cancer Therapeutic Strategies for Prostate Cancer Chapter Summary Clinical Pearls Multiple Choice Questions Answers to Multiple Choice Questions References Chapter 11: Targeted Therapies (Small Molecules) Introduction Epidermal Growth Factor Receptor and Human Epidermal Growth Factor Receptor Vascular Endothelial Growth Factor (VEGF) Receptor Mitogen-Activated Protein Kinase Pathway Anaplastic Lymphoma Kinase B-Cell Receptor-ABL Isocitrate Dehydrogenase and Ten-Eleven Translocation Bruton Tyrosine Kinase Janus Kinase/Signal Transducer and Activator of Transcription FMS-Like Tyrosine Kinase 3 Type I and Type II Tyrosine Kinase Inhibitors Chapter Summary Clinical Pearls Multiple Choice Questions Answers to Multiple Choice Questions References Chapter 12: Monoclonal Antibodies Including Immunoconjugates and Cytokine-Directed Agents Introduction Naked Monoclonal Antibodies Antibody–Drug Conjugates Radioimmunoconjugates Cytokine Therapy Chapter Summary Clinical Pearls Multiple Choice Questions Answers to Multiple Choice Questions Selected References Chapter 13: Immunotherapeutics Including Vaccines, Bispecifics, CAR-T, and Checkpoint Inhibitors Introduction Chapter Summary Clinical Pearls Multiple Choice Questions Answers to Multiple Choice Questions References Chapter 14: Multiple Myeloma as a Paradigm for Multi-Targeted Intervention Introduction Alkylating Agents Immunomodulatory Drugs (IMiDs) Proteasome Inhibitors Corticosteroids Antibodies Other Immune Therapies Epigenetic Modulators Other Anti-MM Drugs Chapter Summary Clinical Pearls Multiple Choice Questions Answers to Multiple Choice Questions Selected References Chapter 15: Transplant-Related Agents Introduction Drugs Used in Transplant Conditioning Regimens Drugs Used for Prevention and Treatment of GVHD Chapter Summary Clinical Pearls Multiple Choice Questions Answers to Multiple Choice Questions Selected References Chapter 16: Basic Drug Development with Structural Considerations Introduction Survival Endpoints Chapter Summary Clinical Pearls Multiple Choice Questions Answers to Multiple Choice Questions Selected References Chapter 17: Integral Components in Development of Clinical Trials: PK/PD, Statistics, and Principles of Rational Combinatorial Therapies Introduction Chapter Summary Clinical Pearls Multiple Choice Questions Answers to Multiple Choice Questions Selected References Chapter 18: Drug Approval and Regulatory Issues Introduction Chapter Summary Multiple Choice Questions Answers to Multiple Choice Questions References Index
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