Cancer Gene Therapy: Past Achievements and Future Challenges

Management Problems in Oncology....Pages 3-10
Adenoviral Vectors....Pages 13-22
Retrovirus Vectors....Pages 23-35
Targetable Gene Delivery Vectors....Pages 37-46
Human α-fetoprotein Transcriptional Regulatory Sequences....Pages 47-56
Tumor-Targeted Salmonella ....Pages 57-63
Mutant Adenoviruses Selectively Replication-Competent in Tumor Cells....Pages 65-71
Polyoma and Papilloma Virus Vectors For Cancer Gene Therapy....Pages 73-82
Cochleates....Pages 83-93
The Use Of Skeletal Muscle To Express Genes For The Treatment Of Cancer....Pages 95-111
Adhesion Molecules in Cancer Biology....Pages 115-126
Cell Cycle Control....Pages 127-140
Killer/DR5, A Novel DNA-Damage Inducible Death Receptor Gene, Links the p53-Tumor Suppressor to Caspase Activation and Apoptotic Death....Pages 143-151
Apoptin®....Pages 153-161
Adenovirus-Mediated Herpes Simplex Thymidine Kinase Gene Therapy For Brain Tumors....Pages 163-170
Development of Clinical Trial of E1A Gene Therapy Targeting HER-2/ neu -overexpressing Breast and Ovarian Cancer....Pages 171-180
Pre-clinical Studies with Tumor Suppressor Genes....Pages 183-192
Gene Therapy for Liver Tumours....Pages 193-205
Adenovirus-mediated Transfer of a p53 Gene in Ovarian Cancer....Pages 207-214
Eliciting Hyperacute Rejection as a Tumor Killing Strategy....Pages 217-227
Innate Immune Therapy For Cancer....Pages 229-237
 Mda-7 , A Novel Melanoma Differentiation Associated Gene with Promise for Cancer Gene Therapy....Pages 239-261
Antisense IGF and Antisense IGF-IR Therapy of Malignancy....Pages 265-272
Sensitization of Tumors to Chemotherapy Through Gene Therapy....Pages 273-291
Design and Testing of Ribozymes for Cancer Gene Therapy....Pages 293-301
Ribozymes....Pages 303-318
The Approach of Triple Helix Formation in Control of Gene Expression and The Treatment of Tumors Expressing IGF-I....Pages 319-332
Dendritic Cell-based Immunization for Cancer Therapy....Pages 335-346
Hybrid Cell Vaccination for Cancer Immunotherapy....Pages 347-354
Modulation of the Immune Response Through 4-1BB....Pages 355-362
Heat Shock Proteins in Cancer Therapy....Pages 363-368
Bi-Specific Antibodies in Cancer Therapy....Pages 369-380
B7.1 and Cytokines....Pages 681-690
Intralesional Vaccinia/GM-CSF Recombinant Virus in the Treatment of Metastatic Melanoma....Pages 391-400
Approaches to Gene-Directed Enzyme Prodrug Therapy (GDEPT)....Pages 403-409
Suicide Gene Therapy....Pages 411-422
Adenoviruses as Gene Delivery Vectors....Pages 423-429
Evaluation of an Inhibitor of DNA Methylation, 5-aza- 2′ -Deoxycytidine, for The Treatment of Lung Cancer and the Future Role of Gene Therapy....Pages 433-446
Vascular Endothelial Growth Factor as a Target for Cancer Gene Therapy....Pages 447-456
Adeno-Associated Virus and Other Potential Vectors for Angiostatin and Endostatin Gene Therapy....Pages 457-466
Potential Applications of Tissue Inhibitor of Metalloproteinase (TIMP) Overexpression For Cancer Gene Therapy....Pages 469-483