Cancer Biology and the Nuclear Envelope: Recent Advances May Elucidate Past Paradoxes

Front Matter....Pages i-xiii
Front Matter....Pages 1-4
The Nuclear Envelope and Cancer: A Diagnostic Perspective and Historical Overview....Pages 5-26
The Role of the Nuclear Lamina in Cancer and Apoptosis....Pages 27-48
The Diagnostic Pathology of the Nuclear Envelope in Human Cancers....Pages 49-75
Nuclear Morphometry, Epigenetic Changes, and Clinical Relevance in Prostate Cancer....Pages 77-99
“To Be or Not to Be in a Good Shape”: Diagnostic and Clinical Value of Nuclear Shape Irregularities in Thyroid and Breast Cancer....Pages 101-121
Front Matter....Pages 123-125
RB and Lamins in Cell Cycle Regulation and Aging....Pages 127-142
Lamina-Associated Polypeptide (LAP)2α and Other LEM Proteins in Cancer Biology....Pages 143-163
NETs and Cell Cycle Regulation....Pages 165-185
Nuclear Envelope Regulation of Signaling Cascades....Pages 187-206
Front Matter....Pages 207-208
Nuclear Envelope: Connecting Structural Genome Organization to Regulation of Gene Expression....Pages 209-244
Studying Lamins in Invertebrate Models....Pages 245-262
The Non-random Repositioning of Whole Chromosomes and Individual Gene Loci in Interphase Nuclei and Its Relevance in Disease, Infection, Aging, and Cancer....Pages 263-279
Front Matter....Pages 281-283
Cancer and the Nuclear Pore Complex....Pages 285-307
Roles of the Nucleoporin Tpr in Cancer and Aging....Pages 309-322
Ran GTPase in Nuclear Envelope Formation and Cancer Metastasis....Pages 323-351
Wnt Signaling Proteins Associate with the Nuclear Pore Complex: Implications for Cancer....Pages 353-372
Front Matter....Pages 373-375
DNA Damage and Lamins....Pages 377-399
Repo-Man at the Intersection of Chromatin Remodelling, DNA Repair, Nuclear Envelope Organization, and Cancer Progression....Pages 401-414
Nuclear Lamins and Oxidative Stress in Cell Proliferation and Longevity....Pages 415-430
Front Matter....Pages 431-433
Nuclear Mechanics in Cancer....Pages 435-470
Front Matter....Pages 431-433
Nuclear Envelope in Nuclear Positioning and Cell Migration....Pages 471-490
Nesprins in Cell Stability and Migration....Pages 491-504
Connecting the Nucleus to the Cytoskeleton for Nuclear Positioning and Cell Migration....Pages 505-520
Front Matter....Pages 521-522
Nuclear Envelope Invaginations and Cancer....Pages 523-535
Mechanisms of Nuclear Size Regulation in Model Systems and Cancer....Pages 537-569
Control of Nuclear Size by NPC Proteins....Pages 571-591
Do Lamins Influence Disease Progression in Cancer?....Pages 593-604
ERRATUM TO: The Non-random Repositioning of Whole Chromosomes and Individual Gene Loci in Interphase Nuclei and Its Relevance in Disease, Infection, Aging, and Cancer....Pages E1-E1
Back Matter....Pages 605-611