Cancer — Between Glycolysis and Physical Constraint

Front Matter....Pages I-XVIII
Introduction....Pages 1-13
Are Cancer Cells Malignant Per Se?....Pages 15-22
Cell Growth: A Balance Between Glycolysis and Physical Constraint....Pages 23-28
Extracellular Constraints Regulate Cell Differentiation....Pages 29-42
Changes in Cellular Constraints During Carcinogenesis....Pages 43-50
Hypoxia Is Responsible for Changes in Cellular Constraints During Inflammation....Pages 51-61
Fibrosis Perpetuates Hypoxia....Pages 63-69
Metastasis: The Hunt for Food....Pages 71-76
Carcinogens Target Cell Respiration and Induce Glycolysis....Pages 77-86
Epidemiology: Aging as the Main Cause of Cancer....Pages 87-93
Aging Causes Inflammation and Fibrosis Mimicking the Impact of Carcinogens....Pages 95-100
Inhibition of Metabolism Slows Aging and Decreases Cancer Incidence....Pages 101-106
A Complication of Hypoxia: The Loss of Cell Polarity Explains Cancer Cell Proliferation....Pages 107-116
The Loss of Cell Differentiation Is a Consequence of Glycolysis....Pages 117-121
Response to Treatment: A Balance Between Glycolysis and Physical Constraints....Pages 123-134
Targeting Glycolysis....Pages 135-144
Conclusion....Pages 145-150