Calcium Signaling

Front Matter....Pages i-xiii
The Regulation of a Cell’s Ca 2+ Signaling Toolkit: The Ca 2+ Homeostasome....Pages 1-25
Methods to Detect Ca 2+ in Living Cells....Pages 27-43
Development and Optimization of FLIPR High Throughput Calcium Assays for Ion Channels and GPCRs....Pages 45-82
Two-Photon Calcium Imaging in the Intact Brain....Pages 83-102
Signaling Through the Extracellular Calcium-Sensing Receptor (CaSR)....Pages 103-142
Ca 2+ Signaling: An Outlook on the Characterization of Ca 2+ Channels and Their Importance in Cellular Functions....Pages 143-157
Ryanodine Receptor Calcium Release Channels: An Evolutionary Perspective....Pages 159-182
Techniques and Methodologies to Study the Ryanodine Receptor at the Molecular, Subcellular and Cellular Level....Pages 183-215
Ryanodine Receptor Physiology and Its Role in Disease....Pages 217-234
Phospholipase C....Pages 235-254
Inositol 1,4,5-Trisphosphate and Its Receptors....Pages 255-279
The Discovery and Structural Investigation of the IP 3 Receptor and the Associated IRBIT Protein....Pages 281-304
Pyridine Nucleotide Metabolites and Calcium Release from Intracellular Stores....Pages 305-323
NAADP on Target....Pages 325-347
Store-Operated Ca 2+ Entry....Pages 349-382
Structure, Regulation and Biophysics of I CRAC , STIM/Orai1....Pages 383-410
Mitochondria-Associated Membranes (MAMs) as Hotspot Ca 2+ Signaling Units....Pages 411-437
Calcium Around the Golgi Apparatus: Implications for Intracellular Membrane Trafficking....Pages 439-460
Calcium Binding Proteins....Pages 461-482
Cytoplasmic Calcium Buffering....Pages 483-498
Elementary Calcium Release Events from the Sarcoplasmic Reticulum in the Heart....Pages 499-509
Calcium Oscillations and Pacemaking....Pages 511-520
Calcium Oscillations and Waves in Cells....Pages 521-529
Calcium Signaling: From Single Channels to Pathways....Pages 531-551
Simulation Strategies for Calcium Microdomains and Calcium-Regulated Calcium Channels....Pages 553-567
Combined Computational and Experimental Approaches to Understanding the Ca 2+ Regulatory Network in Neurons....Pages 569-601
α7 Nicotinic ACh Receptors as a Ligand-Gated Source of Ca 2+ Ions: The Search for a Ca 2+ Optimum....Pages 603-638
The Biology of Protein Kinase C....Pages 639-661
The Role of C2 Domains in PKC Signaling....Pages 663-683
Ca 2+ /Calmodulin-Dependent Protein Kinase II (CaMKII) in the Heart....Pages 685-702
The Role of Molecular Regulation and Targeting in Regulating Calcium/Calmodulin Stimulated Protein Kinases....Pages 703-730
Calcium Sensing in Exocytosis....Pages 731-757
Regulation of Voltage-Gated Calcium Channels by Synaptic Proteins....Pages 759-775
Regulation of Intercellular Calcium Signaling Through Calcium Interactions with Connexin-Based Channels....Pages 777-794
Calcium Signaling in Vascular Smooth Muscle Cells: From Physiology to Pathology....Pages 795-810
Calcium and Endothelium-Mediated Vasodilator Signaling....Pages 811-831
Calcium Signaling in Cerebral Vasoregulation....Pages 833-858
Ca 2+ Signaling Mechanisms in Bovine Adrenal Chromaffin Cells....Pages 859-872
Calcium Stores in Vertebrate Photoreceptors....Pages 873-889
Stem Cells and Calcium Signaling....Pages 891-916
Calcium Signaling in Osteoclast Differentiation and Bone Resorption....Pages 917-932
Calcium Signaling in Renal Tubular Cells....Pages 933-944
Calcium in Epidermis....Pages 945-953
Calcium Signaling in Mast Cells: Focusing on L-Type Calcium Channels....Pages 955-977
Proteinase-Activated Receptors (PARs) and Calcium Signaling in Cancer....Pages 979-1000
Mechanosensory Calcium Signaling....Pages 1001-1015
Role Ca 2+ in Mechanisms of the Red Blood Cells Microrheological Changes....Pages 1017-1038
Calcium Imaging in the Zebrafish....Pages 1039-1071
Calcium Signaling in Xenopus oocyte ....Pages 1073-1094
Calcium Oscillations, Oocyte Activation, and Phospholipase C zeta....Pages 1095-1121
Nuclear Calcium Signaling and Its Involvement in Transcriptional Regulation in Plants....Pages 1123-1143
Remodeling of Calcium Handling in Human Heart Failure....Pages 1145-1174
Proarrhythmic Atrial Calcium Cycling in the Diseased Heart....Pages 1175-1191
Neuronal Calcium Signaling and Alzheimer’s Disease....Pages 1193-1217
Voltage-Gated Ca 2+ Channel Mediated Ca 2+ Influx in Epileptogenesis....Pages 1219-1247
Back Matter....Pages 1249-1267