Calcium-Binding Proteins of the EF-Hand Superfamily: From Basics to Medical Applications

Front Matter ....Pages i-xix
Front Matter ....Pages 1-1
 Using Data Mining to Explore Calmodulin Bibliography  (Jacques Haiech, Marie-Claude Kilhoffer)....Pages 3-14
 Deep Two-Photon Imaging In Vivo with a Red-Shifted Calcium Indicator  (Antje Birkner, Arthur Konnerth)....Pages 15-26
 High-Resolution Calcium Imaging Method for Local Calcium Signaling  (Björn-Philipp Diercks, René Werner, Daniel Schetelig, Insa M. A. Wolf, Andreas H. Guse)....Pages 27-39
 Measurement of Contractility and Calcium Release in Cardiac Spheroids  (Christian Zuppinger)....Pages 41-52
 Simultaneous Recording of Subcellular Ca2+ Signals from the Cytosol and Sarco/Endoplasmic Reticulum: Compartmentalized Dye Loading, Imaging, and Analysis  (Ernst Niggli, Miguel Fernandez-Tenorio)....Pages 53-71
 The Use of Complementary Luminescent and Fluorescent Techniques for Imaging Ca2+ Signaling Events During the Early Development of Zebrafish (Danio rerio)  (Sarah E. Webb, Andrew L. Miller)....Pages 73-93
 Cellular Ca2+-Responding Nanoluciferase Reporter Gene System Directed by Tandemly Repeated Pseudo-palindromic NFAT-Response Elements  (Wei Zhang, Terunao Takahara, Takuya Achiha, Hideki Shibata, Masatoshi Maki)....Pages 95-109
 Designing Calcium-Binding Proteins for Molecular MR Imaging  (Mani Salarian, Shenghui Xue, Oluwatosin Y. Ibhagui, Jenny J. Yang)....Pages 111-125
 Coordination to Divalent Cations by Calcium-Binding Proteins  (Masayuki Nara, Hisayuki Morii, Masaru Tanokura)....Pages 127-134
 Chaperoning Against Amyloid Aggregation: Monitoring In Vitro and In Vivo  (Ravichandran Vignesh, Gopala Krishna Aradhyam)....Pages 135-154
Front Matter ....Pages 155-155
 Ca2+-Binding Proteins of the EF-Hand Superfamily: Diagnostic and Prognostic Biomarkers and Novel Therapeutic Targets  (Claus W. Heizmann)....Pages 157-186
 Gene Transfer of Calcium-Binding Proteins into Adult Cardiac Myocytes  (Brian R. Thompson, Houda Cohen, Addeli Bez Batti Angulski, Joseph M. Metzger)....Pages 187-205
 Expression and Purification of Calmodulin for NMR and Other Biophysical Applications  (Benjamin M. M. Grant, Christopher B. Marshall, Mitsuhiko Ikura)....Pages 207-221
 The Use of Cre/loxP Inducible Mouse Models to Dissect the Specific Roles of Calcineurin Signaling in Myeloid Cells  (Teresa Zelante, Jan Frič)....Pages 223-231
 Calpain Purification Through Calpastatin and Calcium: Strategy and Procedures  (Hung Huy Nguyen, Peter Tompa, Kris Pauwels)....Pages 233-244
 Characterization of the EF-Hand Calcium-Binding Domains of Human Plastins  (Oleg Khassan, Katharine V. Jensen, Andrew G. Woodman, Hans J. Vogel, Hiroaki Ishida)....Pages 245-260
 Expression and Characterization of MICU2, a Ca2+ Sensor Protein  (Wenping Wu, Jimin Zheng, Zongchao Jia)....Pages 261-273
 S100 Proteins in the Innate Immune Response to Pathogens  (Natalia Kozlyuk, Andrew J. Monteith, Velia Garcia, Steven M. Damo, Eric P. Skaar, Walter J. Chazin)....Pages 275-290
 Targeting S100 Calcium-Binding Proteins with Small Molecule Inhibitors  (Paul T. Wilder, Kristen M. Varney, David J. Weber)....Pages 291-310
 Monitoring Interactions Between S100B and the Dopamine D2 Receptor Using NMR Spectroscopy  (Yuning Wang, Roya Tadayon, Gary S. Shaw)....Pages 311-324
 Isolation and Characterization of S100 Protein-Protein Complexes  (Bence Kiss, Péter Ecsédi, Márton Simon, László Nyitray)....Pages 325-338
 The Multifaceted S100A4 Protein in Cancer and Inflammation  (Noona Ambartsumian, Jörg Klingelhöfer, Mariam Grigorian)....Pages 339-365
 Interaction of S100A6 with Target Proteins In Vitro and in Living Cells  (Kyohei Sakane, Fuminori Yamaguchi, Mitsumasa Tsuchiya, Rina Kondo, Naoki Kanayama, Masaki Magari et al.)....Pages 367-377
 Preparation of the Oxidized and Reduced Forms of Psoriasin (S100A7)  (Lisa S. Cunden, Elizabeth M. Nolan)....Pages 379-395
 Preparation and Iron Redox Speciation Study of the Fe(II)-Binding Antimicrobial Protein Calprotectin  (Rose C. Hadley, Elizabeth M. Nolan)....Pages 397-415
 Structural Analysis of S100A8 Complex with Zinc and Calcium: A General Protocol for the Study of S100 Proteins in the Presence of Divalent Cations by X-Ray Crystallography  (Laure Yatime)....Pages 417-435
 Analysis of Ca2+-Dependent Weibel–Palade Body Tethering by Live Cell TIRF Microscopy: Involvement of a Munc13-4/S100A10/Annexin A2 Complex  (Nina Criado Santos, Tarek Chehab, Anna Holthenrich, Volker Gerke)....Pages 437-445
 Analysis of S100A11 in DNA Damage Repair  (Franziska Foertsch, Christian Melle)....Pages 447-460
 Fluorine-18 Labeling of S100 Proteins for Small Animal Positron Emission Tomography  (Markus Laube, Torsten Kniess, Christin Neuber, Cathleen Haase-Kohn, Jens Pietzsch)....Pages 461-485
 Reviewing the Crystal Structure of S100Z and Other Members of the S100 Family: Implications in Calcium-Regulated Quaternary Structure  (Vito Calderone, Marco Fragai, Claudio Luchinat)....Pages 487-499
 High Sensitive Quantitative Binding Assays Using a Nanoluciferase-Fused Probe for Analysis of ALG-2-Interacting Proteins  (Wei Zhang, Rina Matsuo, Terunao Takahara, Hideki Shibata, Masatoshi Maki)....Pages 501-516
 Calcium-Induced Protein Folding in Calumenin and Calmodulin  (Marco Mazzorana, Thomas Lykke-Møller Sørensen)....Pages 517-537
 Measuring Calumenin Impact on ER-Calcium Depletion Using Transient Calumenin Overexpression and Silencing  (Réginald Philippe, Olivier Mignen)....Pages 539-550
 Secretagogin Purification and Quality Control Strategies for Biophysical and Cell Biological Studies  (Anand Kumar Sharma, Radhika Khandelwal, Yogendra Sharma)....Pages 551-566
 Tryptophan Scanning Mutagenesis of EF-Hand Motifs  (Uday Kiran, Michael R. Kreutz, Yogendra Sharma, Asima Chakraborty)....Pages 567-581
 Mapping Calcium-Sensitive Regions in GCAPs by Site-Specific Fluorescence Labelling  (Karl-Wilhelm Koch, Jens Christoffers)....Pages 583-594
 Quantification of Human Swiprosin-1/EFhd2 Expression on Protein and RNA Level  (Barbara G. Fürnrohr, Dirk Mielenz)....Pages 595-605
 Three-Dimensional Reconstruction Imaging Method to Study the Function of EFHD2 in Invadopodia Formation  (Yun Hyun Huh, Yu Ra Yeo, Woo Keun Song)....Pages 607-613
 Characterization of Calcium-Binding Proteins from Parasitic Worms  (Charlotte M. Thomas, David J. Timson)....Pages 615-641
Front Matter ....Pages 643-643
 High-Sensitivity Troponin Assays in Clinical Diagnostics of Acute Coronary Syndrome  (Danielle Hof, Arnold von Eckardstein)....Pages 645-662
 Targeted Mass Spectrometry of S100 Proteins  (Juan Martínez-Aguilar, Mark P. Molloy)....Pages 663-678
 Clinical Use of the Calcium-Binding S100B Protein, a Biomarker for Head Injury  (Ramona Astrand, Johan Undén)....Pages 679-690
 Serum S100B Levels in Melanoma  (Anna Lisa Frauchiger, Reinhard Dummer, Joanna Mangana)....Pages 691-700
 The Ca2+-Binding S100B Protein: An Important Diagnostic and Prognostic Neurobiomarker in Pediatric Laboratory Medicine  (Diego Gazzolo, Francesca Pluchinotta, Giuseppe Lapergola, Simone Franchini)....Pages 701-728
 S100A7 in Psoriasis: Immunodetection and Activation by CRISPR technology  (Mariagrazia Granata, Evangelia Skarmoutsou, Maria Clorinda Mazzarino, Fabio D’Amico)....Pages 729-738
 S100A8/A9 in Myocardial Infarction  (Gopalkrishna Sreejit, Sunil Kiran Nooti, Baskaran Athmanathan, Prabhakara Reddy Nagareddy)....Pages 739-754
 Enzyme-Linked Immunosorbent Assay to Measure S100A12 in Fecal Samples of Children and Adults  (Steven T. Leach, Andrew S. Day)....Pages 755-761
 S100 Proteins as Biomarkers in Risk Estimations for Malignant Transformation in Oral Lesions  (Rainer Probstmeier, Dominik Kraus, Matthias Wenghoefer, Jochen Winter)....Pages 763-771
Back Matter ....Pages 773-779