Calcium Antagonists: Pharmacology and Clinical Research

Front Matter....Pages i-xxv
Structure-Function Studies of the Voltage-Dependent Calcium Channels....Pages 1-8
Regulation of Calcium Channels By Protein Phosphorylation....Pages 9-14
Interactions of Lacidipine and other Calcium Channel Drugs with Biological Membranes: A Structural Model for Receptor/Drug Binding Utilizing the Membrane Bilayer....Pages 15-23
Regulation of Calcium Channels in Vascular Smooth Muscle....Pages 25-30
Calcium and the Production of Endothelium-Derived Vasoactive Factors....Pages 31-36
Postnatal Development of Calcium Channels in Cardiac Muscle....Pages 37-42
The Hemodynamic Effects of Calcium Antagonists under Pathological Conditions....Pages 43-48
Calcium, Ischemia, and the Calcium Antagonists....Pages 49-58
Multiple Organ Protection through Endothelial Cell Stabilization: A Mechanism of Action of Calcium Antagonists?....Pages 59-63
New Insight into the Vascular Properties of Lacidipine....Pages 65-69
Effect of Felodipine on Left Ventricular Performance in Conscious Dogs: Assessment by Left Ventricular Pressure-Volume Analysis....Pages 71-76
Lacidipine in the Treatment of Hypertension: Clinical Data....Pages 77-85
Insights in the Cardioprotective Mechanism of the New Drug R56865....Pages 87-92
Do the Differences Between Calcium Antagonists Matter When Treating Hypertension?....Pages 93-98
Effects of Lacidipine on Ischemic and Reperfused Myocardium....Pages 99-106
Atherogenic Activity caused by Excess Membrane Cholesterol in Arterial Smooth Muscle: Role of Calcium Channels....Pages 107-115
Understanding the Initiating Factors in Atherosclerosis: Implications for Intervention....Pages 117-124
Calcium Antagonists and Lipid-Lowering Agents in the Protection of the Arterial Wall....Pages 125-132
Calcium Channel Blockers as Agents for the Treatment of Atherosclerosis....Pages 133-138
Anti-Arteriosclerotic Effects of Calcium Antagonists: Do Calcium Antagonists Inhibit Cholesterol Accumulation in Coronary Arteries of Cholesterol-Fed Rabbits?....Pages 139-148
Cholesterol Enrichment During Dietary Atherosclerosis Alters Smooth Muscle Plasma Membrane Width and Structure: Evidence for Reversal by the 1,4-Dihydropyridine Amlodipine....Pages 149-155
Lacidipine and Atherosclerosis....Pages 157-164
Potentiation of the Antiplatelet Effect of Aspirin by the Calcium Channel Antagonist Amlodipine....Pages 165-171
The Effects of Lacidipine on Insulin Sensitivity....Pages 173-177
Calcium Antagonists, Hypertension, and Atherosclerosis....Pages 179-181
Expression, Localization, and Function of Calcium Channels in NGF-Treated PC12 Cells....Pages 183-188
Receptor-Mediated Inhibition of Calcium Currents and Synaptic Transmission in Cultured Hippocampal Pyramidal Neurons....Pages 189-194
Calcium Stores and Calcium Channels of Cerebellum Purkinje Cells....Pages 195-203
Calcium Channel Signaling in Astrocytes....Pages 205-213
Studies on Synaptosomes: New Insights on Calcium Antagonists....Pages 215-220
The Regulation of Neuronal Calcium Channels....Pages 221-229
Effect of Aging on Brain Voltage-Dependent Calcium Channels....Pages 231-240
Calcium Overload Blockade in Neurons and Cardiomyocytes....Pages 241-247
Effect of Nicardipine on Antioxidant Enzymatic Activities and LTC 4 Release in Experimental SAH....Pages 249-255
Treatment of Acute Ischemic Stroke with Calcium Antagonists....Pages 257-263
Pharmacological Approach to Acute Ischemic Stroke....Pages 265-270
Calcium Antagonist and Subarachnoid Hemorrhage....Pages 271-277
Pharmacological Basis for use of Calcium Antagonists in Dementia....Pages 279-284
Calcium Channels in Intestinal Smooth Muscle....Pages 285-290
Pharmacological Aspects of Calcium Channels in Nonvascular Smooth Muscle....Pages 291-297
Pharmacology of Calcium Antagonists Active on Gastrointestinal Calcium Channels....Pages 299-313
Role of Calcium Channels in Pharmacological Modulation of Gastrointestinal Motility....Pages 315-323
A New Class of Calcium Antagonist Selective for the GI Tract....Pages 325-335
Therapeutic Application of Calcium Antagonists in Gastroenterology....Pages 337-347
Calcium Antagonists and the Kidney: Implications for Renal Protection....Pages 349-354
Calcium Antagonists Improve the Outcome after Renal Transplantation....Pages 355-361
Reversal of P-Glycoprotein-Mediated Multidrug Resistance in Tumor Cells by Calcium Channel Antagonists....Pages 363-368
Reversal of Multiple Drug Resistance (MDR) in Malaria by Reverse Isomers of Calcium Channel Blockers and its Possible Application to Cancer and MDR Parasitic Diseases....Pages 369-375
Back Matter....Pages 377-381