Breast Cancer Metastasis and Drug Resistance: Challenges and Progress

Front Matter ....Pages i-xviii
 Breast Cancer Statistics: Recent Trends  (Aamir Ahmad)....Pages 1-7
 Epidemiology of Breast Cancer in Women  (Steven S. Coughlin)....Pages 9-29
 Health and Racial Disparity in Breast Cancer  (Clement G. Yedjou, Jennifer N. Sims, Lucio Miele, Felicite Noubissi, Leroy Lowe, Duber D. Fonseca et al.)....Pages 31-49
 Breast Cancer: Current Perspectives on the Disease Status  (Mohammad Fahad Ullah)....Pages 51-64
 Role of Autophagy in Breast Cancer Development and Progression: Opposite Sides of the Same Coin  (Mirna Azalea Romero, Oznur Bayraktar Ekmekcigil, Bakiye Goker Bagca, Cigir Biray Avci, Uteuliyev Yerzhan Sabitaliyevich, Tokmurziyeva Gulnara Zhenisovna et al.)....Pages 65-73
 Breast Cancer Heterogeneity in Primary and Metastatic Disease  (Lauren Kalinowski, Jodi M. Saunus, Amy E. McCart Reed, Sunil R. Lakhani)....Pages 75-104
 Bone Metastasis of Breast Cancer  (Rie K. Tahara, Takae M. Brewer, Richard L. Theriault, Naoto T. Ueno)....Pages 105-129
 Therapeutic Options for Metastatic Breast Cancer  (Manpreet Sambi, Bessi Qorri, William Harless, Myron R. Szewczuk)....Pages 131-172
 Chemotherapy and Inflammatory Cytokine Signalling in Cancer Cells and the Tumour Microenvironment  (Derek W. Edwardson, Amadeo M. Parissenti, A. Thomas Kovala)....Pages 173-215
 Current Updates on Trastuzumab Resistance in HER2 Overexpressing Breast Cancers  (Aamir Ahmad)....Pages 217-228
 Non-coding RNAs as Mediators of Tamoxifen Resistance in Breast Cancers  (Mohd Farhan, Mohammad Aatif, Prasad Dandawate, Aamir Ahmad)....Pages 229-241
 TRAIL Mediated Signaling in Breast Cancer: Awakening Guardian Angel to Induce Apoptosis and Overcome Drug Resistance  (Ning Yin, Liu Yi, Sumbul Khalid, Ulku Ozbey, Uteuliev Yerzhan Sabitaliyevich, Ammad Ahmad Farooqi)....Pages 243-252
 Current State of Platinum Complexes for the Treatment of Advanced and Drug-Resistant Breast Cancers  (Bernhard Biersack, Rainer Schobert)....Pages 253-270
 Targeting of JAK-STAT Signaling in Breast Cancer: Therapeutic Strategies to Overcome Drug Resistance  (Sobia Tabassum, Rashda Abbasi, Nafees Ahmad, Ammad Ahmad Farooqi)....Pages 271-281
 Role of mTORC1 and mTORC2 in Breast Cancer: Therapeutic Targeting of mTOR and Its Partners to Overcome Metastasis and Drug Resistance  (Ghazala Butt, Durray Shahwar, Muhammad Zahid Qureshi, Rukset Attar, Misbah Akram, Yelda Birinci et al.)....Pages 283-292
 Epigenetics of Breast Cancer: Clinical Status of Epi-drugs and Phytochemicals  (Samriddhi Shukla, Dhanamjai Penta, Priya Mondal, Syed Musthapa Meeran)....Pages 293-310
 Targeting CSC in a Most Aggressive Subtype of Breast Cancer TNBC  (Bin Bao, Ananda S. Prasad)....Pages 311-334
 Cross-Roads to Drug Resistance and Metastasis in Breast Cancer: miRNAs Regulatory Function and Biomarker Capability  (Nataly Naser Al Deen, Farah Nassar, Rihab Nasr, Rabih Talhouk)....Pages 335-364
 NEDD4 Family of E3 Ubiquitin Ligases in Breast Cancer: Spotlight on SMURFs, WWPs and NEDD4  (Ghazala Butt, Ilhan Yaylim, Rukset Attar, Aliye Aras, Mirna Azalea Romero, Muhammad Zahid Qureshi et al.)....Pages 365-375
 Emerging Novel Therapeutics in Triple-Negative Breast Cancer  (Tomas G. Lyons, Tiffany A. Traina)....Pages 377-399
 Breast Cancer: Proteolysis and Migration  (Kingsley O. Osuala, Kyungmin Ji, Raymond R. Mattingly, Bonnie F. Sloane)....Pages 401-411
 Current and Emerging 3D Models to Study Breast Cancer  (Sophie Roberts, Sally Peyman, Valerie Speirs)....Pages 413-427