Breast Cancer

Front Matter ....Pages i-xiv
Front Matter ....Pages 1-1
 Fundamental Pathways in Breast Cancer 1: Signaling from the Membrane  (Yekaterina Poloz, Ryan J. O. Dowling, Vuk Stambolic)....Pages 3-12
 Fundamental Pathways in Breast Cancer 2: Maintenance of Genomic Stability  (Chiara Gorrini, Tak W. Mak)....Pages 13-17
 Fundamental Pathways in Breast Cancer 3: Estrogen Biology  (Luca Magnani, Darren K. Patten)....Pages 19-26
 Fundamental Pathways in Breast Cancer 4: Signaling to Chromatin in Breast Development  (Luca Mazzarella, Pier Giuseppe Pelicci)....Pages 27-37
 Breast Cancer Microenvironment and the Metastatic Process  (George Sflomos, Cathrin Brisken)....Pages 39-48
 Mouse Models of Breast Cancer: Deceptions that Reveal the Truth  (Joana Pinto Couto, Mohamed Bentires-Alj)....Pages 49-60
Front Matter ....Pages 61-61
 Epidemiology, Lifestyle, and Environmental Factors  (Patrick Maisonneuve)....Pages 63-72
 Breast Cancer Genetics  (Ana Carolina Ribeiro Chaves de Gouvea, Judy E. Garber)....Pages 73-86
 Chemoprevention  (Andrea De Censi, Bernardo Bonanni, Massimiliano Cazzaniga)....Pages 87-94
 Surgical Prevention  (Paolo Veronesi, Nickolas Peradze)....Pages 95-99
Front Matter ....Pages 101-101
 Premalignant and Pre-invasive Lesions of the Breast  (Elena Guerini-Rocco, Nicola Fusco)....Pages 103-120
 Prognostic and Predictive Role of Genetic Signatures  (Giancarlo Pruneri, Francesca Boggio)....Pages 121-131
 Special Types of Breast Cancer and Non-epithelial Tumors  (Giovanni Mazzarol, Sara Pirola)....Pages 133-139
 Pathology After Neoadjuvant Treatments  (W. Fraser Symmans)....Pages 141-147
 Breast Cancer Genomics  (Maurizio Scaltriti)....Pages 149-156
 The Pathology Report  (Andrea Vingiani, Giuseppe Viale)....Pages 157-168
Front Matter ....Pages 169-169
 Radiological Screening of Breast Cancer: Evolution  (Alfonso Frigerio, Francesco Sardanelli, Franca Podo)....Pages 171-203
 Innovation in Breast Cancer Radiology  (Rumana Rahim, Michael J. Michell, Viviana Londero, Chiara Zuiani, Martina Zanotel, Massimo Bazzocchi et al.)....Pages 205-246
 Nuclear Medicine in the Clinical Management (ROLL, SNB, and PET)  (Giovanni Paganelli, Federica Matteucci, Laura Gilardi)....Pages 247-264
 One-Step Systemic Staging for Patients with Breast Cancer  (Giuseppe Petralia, Anwar R. Padhani)....Pages 265-276
 Imaging Findings After Surgery  (Silvia Pérez Rodrigo, Elizabeth A. Morris)....Pages 277-315
 Integrated Breast Biopsy for Best Radiological Diagnosis of Breast Cancer  (Enrico Cassano, Chiara Trentin)....Pages 317-331
Front Matter ....Pages 333-333
 Conservative Surgery  (Umberto Veronesi)....Pages 335-344
 The Conservative Mastectomy  (Alberto Luini)....Pages 345-348
 Surgical Treatment of Local Recurrence in Breast Cancer Patients  (Jose Vila, Francisco Ripoll, Oreste D. Gentilini)....Pages 349-356
 Management of the Axilla  (Viviana Galimberti)....Pages 357-363
 Management of Intraepithelial Disease  (Antonio Toesca)....Pages 365-368
 Breast-Conserving Surgery After Neoadjuvant Therapy  (Mahdi Rezai, Stefan Kraemer)....Pages 369-383
 Surgical Treatment of the Primary Tumor in Patients with Metastatic Breast Cancer (Stage IV Disease)  (Mattia Intra)....Pages 385-398
 Breast Cancer in Lymphoma Survivors  (Mattia Intra, Denise Mattar Fanianos)....Pages 399-414
 Surgery of Metastases in Stage IV Breast Cancer  (Elisabetta Pennacchioli, Gianluca Varano, Franco Orsi, Pierpaolo Prestianni, Gianmarco Orsolini, Angela Cioffi)....Pages 415-424
Front Matter ....Pages 425-425
 Oncoplastic Surgery  (Cicero Urban, Mario Rietjens)....Pages 427-433
 Delayed Breast Reconstruction  (Cicero Urban, Flavia Kuroda)....Pages 435-442
 Immediate Breast Reconstruction (Direct to Implant)  (Mario Rietjens, Pietro Loschi, Leonardo Pires Novais Dias)....Pages 443-455
 Breast Reconstruction with Tissue Expander and Definitive Implant Replacement  (Thomas H. S. Fysh, R. Rainsbury)....Pages 457-464
 The Pedicled TRAM Flap in Breast Reconstruction  (Glyn Jones)....Pages 465-483
 Breast Reconstruction with Free Flaps  (Fabio Santanelli di Pompeo, Benedetto Longo, Rosaria Laporta)....Pages 485-494
 Contralateral Breast Management  (Marco Klinger, Luca Maione, Silvia Giannasi, Valeria Bandi, Barbara Banzatti, Alessandra Veronesi et al.)....Pages 495-501
 Lipofilling  (J. Y. Petit, V. Lohsiriwat, M. Rietjens)....Pages 503-511
 Breast Reconstruction with Biological and Non-biological Meshes and Matrices  (Rachel Rolph, Jian Farhadi)....Pages 513-520
 How to Manage Complications in Breast Reconstruction  (Francesca De Lorenzi)....Pages 521-532
Front Matter ....Pages 533-533
 Adjuvant Systemic Therapies by Subtypes: Guidelines  (Antonella Palazzo, Marco Colleoni)....Pages 535-539
 Primary Systemic Therapies: Guidelines  (Jenny Furlanetto, Gunter von Minckwitz)....Pages 541-548
 Treatment of Advanced Disease: Guidelines  (Rosario Andre, Simona Ruxandra Volovat, Fatima Cardoso)....Pages 549-556
 Endocrine Therapies in the Adjuvant and Advanced Disease Settings  (Olivia Pagani)....Pages 557-568
 Chemotherapy Regimens in the Adjuvant and Advanced Disease Settings  (Christopher D. Hart, Laura Biganzoli, Angelo Di Leo)....Pages 569-576
 Anti-HER2 Therapies in the Adjuvant and Advanced Disease Settings  (Elisabetta Munzone)....Pages 577-591
 Adjuvant Treatment with Bone-Targeting Agents (Bisphosphonates and Anti-RANK-Ligand Antibody)  (Michael Gnant)....Pages 593-598
 Systemic Treatment for Specific Medical Situations  (Silvia Dellapasqua)....Pages 599-607
Front Matter ....Pages 611-611
 Conceptual Basis and Principles of Radiation Oncology  (Roberto Orecchia)....Pages 611-619
 Whole-Breast Irradiation Following Breast-Conserving Surgery for Invasive Breast Cancer  (Anna Kirby)....Pages 621-630
 Whole-Breast Radiation Following Breast-Conserving Surgery in Noninvasive Cancer  (Beryl McCormick)....Pages 631-635
 Postmastectomy Radiation Therapy of Early Breast Cancer  (Birgitte Vrou Offersen, Mette Skovhus Thomsen)....Pages 637-644
 Concurrent Use of Radiation Therapy and Targeted Molecules in the Breast Cancer Treatment  (Youlia M. Kirova, Alain Fourquet)....Pages 645-653
 Accelerated Partial Breast Irradiation  (Nina N. Sanford, Alphonse G. Taghian)....Pages 655-669
 Intraoperative Radiotherapy with Electrons (ELIOT)  (Maria Cristina Leonardi)....Pages 671-684
 Radiotherapy for Metastatic Lesions  (Per Karlsson, Dan Lundstedt)....Pages 685-693
Front Matter ....Pages 695-695
 Emergencies in Breast Cancer  (Lorenzo Gianni, Maria Vittoria Stefania Nicoletti, Valentina Arcangeli)....Pages 697-708
 Breast Cancer (Diagnosed) During Pregnancy: Adapting Recent Advances in Breast Cancer Care for Pregnant Patients  (Sibylle Loibl, André Schmidt, Oreste D. Gentilini, Bella Kaufman, Christine Kuhl, Carsten Denkert et al.)....Pages 709-718
 Chest Wall Disease: The Clinical Continuum Between Inflammatory and Lymphangitic Breast Cancer  (Giuseppe Curigliano)....Pages 719-727
 Fertility Issues in Patients with Breast Cancer or Survivors  (Matteo Lambertini, Hatem A. Azim Jr, Fedro A. Peccatori)....Pages 729-737
 Breast Cancer and Sexuality with Focus in Young Women: From Evidence-Based Data to Women’s Wording to Treatment Perspectives  (Alessandra Graziottin)....Pages 739-752
 Male Breast Cancer  (Laura Ottini, Carlo Capalbo)....Pages 753-762
 Treatment of Central Nervous System Involvement  (E. Munzone, C. Casali, M. Del Bene, F. Di Meco)....Pages 763-767
 Follow-Up of Patients with Breast Cancer  (Lorenzo Gianni, Alessandra Affatato, Davide Tassinari)....Pages 769-778
Front Matter ....Pages 779-779
 Targeting Immune Checkpoint  (Angela Esposito, Giuseppe Curigliano)....Pages 781-785
 Targeting PI3K/AKT/mTOR Pathway  (Carmen Criscitiello, Giuseppe Curigliano)....Pages 787-793
 Targeting Genome Instability and DNA Repair  (Marzia Locatelli, Giuseppe Curigliano)....Pages 795-805
 Targeting the CDK4/6 Pathway in Breast Cancer  (Luca Malorni, Ilenia Migliaccio, Cristina Guarducci, Martina Bonechi, Angelo Di Leo)....Pages 807-817
 Targeting FGFR Pathway in Breast Cancer  (Carmen Criscitiello, Angela Esposito, Giuseppe Curigliano)....Pages 819-822
 Integrating Next-Generation Sequencing Data in Trial Design  (Giuseppe Curigliano, Angela Esposito, Marzia Locatelli, Carmen Criscitiello)....Pages 823-827
Front Matter ....Pages 829-829
 Lifestyle and Breast Cancer  (Rowan T. Chlebowski)....Pages 831-839
 Psychological Support in Breast Cancer Patients: A Personalized Approach  (Chiara Fioretti, Ketti Mazzocco, Gabriella Pravettoni)....Pages 841-847
 HIFU and Radio Frequency as Alternatives to Surgery  (Franco Orsi, Giovanni Mauri)....Pages 849-854
 Hyperthermia with Radiotherapy and with Systemic Therapies  (J. van der Zee, G. C. van Rhoon)....Pages 855-862
 Electrochemotherapy of Breast Cancer  (Luca G. Campana, Louise Wichmann Matthiessen, Marko Snoj, Gregor Sersa)....Pages 863-874
 Circulating miRNA in Early Diagnosis  (Fabrizio Bianchi)....Pages 875-881
 Relevance of Stem Cells  (Salvatore Pece, Maria Grazia Malabarba, Pier Paolo Di Fiore, Daniela Tosoni)....Pages 883-888
Front Matter ....Pages 889-889
 Subgroup Analyses and Information from Clinical Trials on Breast Cancer  (Wai-Ki Yip)....Pages 891-903
 The Methodology of Meta-Analyses and Its Potential Contribution to Patient Care  (di Sara Gandini)....Pages 905-913
 Trial Designs and Biostatistics for Molecular-Targeted Agents  (William T. Barry)....Pages 915-924
 Bioinformatics for Clinical Use in Breast Cancer  (Fabrizio Bianchi)....Pages 925-928