Brain Transcriptome

 Content: Cover image; Title page; Table of Contents; Copyright; Contributors; Chapter One: Introduction to Sequencing the Brain Transcriptome; Abstract; 1 Introduction; 2 From Microarrays to RNA-Seq; 3 NGS Platforms; 4 RNA-Seq Overview; 5 RNA-Seq and Data Analysis; 6 Sequencing the Brain Transcriptome; 7 Conclusions; Acknowledgments; Chapter Two: Analysis Considerations for Utilizing RNA-Seq to Characterize the Brain Transcriptome; Abstract; 1 Introduction; 2 Defining and Quantifying Transcript/Gene Expression; 3 Detecting Differential Expression; 4 Frameworks for Interpretation; 5 Summary. Chapter Three: Data Integration and Reproducibility for High-Throughput TranscriptomicsAbstract; 1 Opportunities for Secondary Use of Data and Meta-Anlaysis in Transcriptomics; 2 Selecting the Unit of Comparison; 3 Metrics for Agreement; 4 Studies on Reproducibility and Validation; 5 Guidelines for Cross-Platform Studies; 6 Other Data Integration Considerations; 7 Summary; Chapter Four: Coexpression and Cosplicing Network Approaches for the Study of Mammalian Brain Transcriptomes; Abstract; 1 Introduction; 2 Construction of Coexpression and Cosplicing Networks. 3 Cosplicing Network Construction4 Biological Annotation of Coexpression and Cosplicing Networks; 5 Effects of Genetic Selection on Gene Networks; 6 Module Preservation Across Subpopulations and Species; 7 Module Disruption Related to Behavioral Changes; 8 Summary and Future Directions; Chapter Five: Splicing in the Human Brain; Abstract; 1 Pre-mRNA Splicing in Human Cells; 2 Alternative Pre-mRNA Splicing; 3 Tissue-Specific Alternative Splicing; 4 Alternative Splicing in the Brain; 5 Brain-Specific Splicing Regulation; 6 Transcription-Coupled Regulation of Alternative Splicing. 7 Cotranscriptional and Posttranscriptional Splicing8 Global Analysis of Pre-mRNA Splicing; 9 The Influence of RNA Extraction Methods on Transcriptome Analysis; 10 Computational Methods to Study Splicing Dynamics; Chapter Six: Understanding Complex Transcriptome Dynamics in Schizophrenia and Other Neurological Diseases Using RNA Sequencing; Abstract; 1 Introduction; 2 RNA-Seq Studies on Neurological Disorders; 3 Quantifying Transcriptome Dynamics in Neurological Disorders; 4 Discussion and Perspectives; Chapter Seven: The Central Role of Noncoding RNA in the Brain; Abstract; 1 Introduction. 2 The Long and Short of Noncoding RNAs3 Types and Function of lncRNAs; 4 RNA Structure; 5 Splicing; 6 NcRNA Editing; 7 Epigenetic Modifications; 8 ncRNAs Are Involved in Neuronal Development, Maintenance, and Plasticity; 9 Evolutionary Role of ncRNAs and Primate Specificity; 10 The Role of (Retro)transposons and Pseudogenes in ncRNA Evolution; 11 ncRNAs and Disease; 12 Perspectives and Outlook; Acknowledgments; Chapter Eight: Genetics of Gene Expression in CNS; Abstract; 1 Introduction; 2 Genetic Resources for eQTL Analysis in Mice; 3 Genetic Mapping Methods; 4 RNA-seq eQTL Studies.
 Abstract:             Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume, concentrates on the brain transcriptome. Brings together cutting-edge research on the brain transcriptome