Brain Hypothermia Treatment

Front Matter....Pages II-XV
Front Matter....Pages 1-1
Introduction....Pages 3-4
Global and Focal Cerebral Ischemia....Pages 7-8
Limitations of Postischemic Hypothermia....Pages 9-9
The Importance of Chronic Outcome Measures in Assessing Neuroprotective Strategies....Pages 10-11
Traumatic Brain Injury....Pages 12-13
Traumatic Axonal Injury....Pages 14-15
Behavioral Improvements with Posttraumatic Hypothermia....Pages 16-17
Brain Tissue Temperature Measurements in Clinical Setting....Pages 18-18
Traumatic and Ischemic Hyperthermia....Pages 19-19
Rewarming Phase....Pages 20-20
Therapeutic Hypothermia in Complicated Models of Traumatic Brain Injury....Pages 21-21
Mechanisms of Hypothermic Protection....Pages 22-22
Excitotoxicity....Pages 23-23
Free Radical Production....Pages 24-24
Decrease of Vascular Permeability....Pages 25-25
Nitric Oxide....Pages 26-26
Cerebral Blood Flow....Pages 27-27
Inflammation....Pages 28-29
Gene Expression and Apoptosis....Pages 30-31
Summary and Future Directions....Pages 32-33
Front Matter....Pages 35-35
Introduction....Pages 37-39
Mechanism of Brain Damage and Management of Severe Brain Injury Based on Laboratory Studies....Pages 43-50
History of Clinical Trials of Hypothermia Treatment of Severe Brain Injury....Pages 51-54
Secondary Brain Injury Mechanism of Hypothalamus—Pituitary—Adrenal Axis Neurohormonal Activation in Severely Brain-Injured Patients....Pages 55-67
Clinical Failures of Previous Hypothermia Management....Pages 68-73
The Difference in Brain Injury Mechanism in Experimental Laboratory Models and Human Patients....Pages 74-75
The Regulatory Mechanism of Brain Tissue Temperature and Brain Thermo-pooling....Pages 76-77
The Target of Treatment of Severe Brain Injury in the Acute Stage....Pages 78-84
New Concept of Brain Hypothermia Treatment....Pages 85-91
Contraindications....Pages 95-96
Indications....Pages 97-97
Beyond Indication and Contraindication....Pages 98-99
Induction of Brain Hypothermia....Pages 103-105
The Protocol for Brain Hypothermia Treatment....Pages 106-109
Mistakes and Pitfalls of Brain Hypothermia Treatment....Pages 110-119
Concepts in Brain Tissue Temperature Control....Pages 120-124
Management of Brain Tissue Temperature....Pages 125-131
Intensive Care Unit Bed Design for Brain Hypothermia....Pages 132-132
Design of the Intensive Care Unit for Brain Hypothermia Treatment....Pages 133-133
Preparation for Management of Brain Hypothermia....Pages 134-136
Front Matter....Pages 35-35
Noninvasive Monitoring of Brain Damage....Pages 137-140
Neuron Protection in Injured Brain Tissue During Surgery....Pages 141-144
Prolonged Anesthesia for Brain Hypothermia Treatment in ICU....Pages 145-146
Imaging and Monitoring for Brain Hypothermia Management....Pages 147-164
Induction of Brain Hypothermia Treatment....Pages 165-174
Management During the Cooling Stage....Pages 175-216
Timing of Rewarming....Pages 217-218
Preconditioning for Rewarming....Pages 219-223
Management of Rewarming....Pages 224-232
Clinical Issues in the Management of Unconsciousness and Vegetative State Patients....Pages 235-236
The New Concept of Unconsciousness and Mechanism of Vegetation....Pages 237-240
Diagnosis of Reversibility of the Vegetative State....Pages 241-242
Management of Complicated Neuronal Dysfunction: Emotion, Memory, Cognition, and Behavior....Pages 243-244
Surgical Management After Brain Hypothermia Treatment to Prevent Vegetation and Memory Disturbance....Pages 245-245
Indications and Criteria for Dopamine Replacement Therapy....Pages 246-246
Brain Hypothermia After Resuscitation from Cardiopulmonary Arrest....Pages 249-253
Brain Hypothermia for Occlusive Cerebral Stroke....Pages 254-257
Special Consideration of Brain Hypothermia Treatment for Subarachnoid Hemorrhage....Pages 258-265
Severe Brain Trauma....Pages 269-271
Cardiac Arrest....Pages 272-273
Front Matter....Pages 35-35
Critical Path of Brain Hypothermia Treatment....Pages 277-288
Closing Remarks....Pages 289-290
Back Matter....Pages 291-325