Brain Edema XVI: Translate Basic Science into Clinical Practice

Front Matter....Pages i-xv
Front Matter....Pages 1-1
The Evolution of the Clinical Use of Osmotic Therapy in the Treatment of Cerebral Edema....Pages 3-6
Transcranial Near-Infrared Laser Therapy for Stroke: How to Recover from Futility in the NEST-3 Clinical Trial....Pages 7-12
Human Data Supporting Glyburide in Ischemic Stroke....Pages 13-18
Mechanisms Underlying Astrocyte Endfeet Swelling in Stroke....Pages 19-22
Hypoxia and Inflammation-Induced Disruptions of the Blood-Brain and Blood-Cerebrospinal Fluid Barriers Assessed Using a Novel T1-Based MRI Method....Pages 23-28
Vascular Integrity in the Pathogenesis of Brain Arteriovenous Malformation....Pages 29-35
Front Matter....Pages 37-37
Role of Circulating Immune Cells in Stroke and Preconditioning-Induced Protection....Pages 39-44
Humoral Mediators of Remote Ischemic Conditioning: Important Role of eNOS/NO/Nitrite....Pages 45-48
Exsanguination Postconditioning of ICH (EPIC-H) Using the Lancet for Brain Bleed in Rodents, Preliminary Study....Pages 49-53
Sevoflurane Preconditioning Confers Neuroprotection via Anti-apoptosis Effects....Pages 55-61
Remote Ischemic Postconditioning (RIPC) After GMH in Rodents....Pages 63-67
Front Matter....Pages 69-69
Patterns of Behavioral Deficits in Rodents Following Brain Injury Across Species, Gender, and Experimental Model....Pages 71-75
Large Animal Stroke Models vs. Rodent Stroke Models, Pros and Cons, and Combination?....Pages 77-81
Endovascular Perforation Murine Model of Subarachnoid Hemorrhage....Pages 83-88
Assessment of the Correlations Between Brain Weight and Brain Edema in Experimental Subarachnoid Hemorrhage....Pages 89-92
Analysis of Small Ischemic Lesions in the Examinees of a Brain Dock and Neurological Examination of Animals Subjected to Cortical or Basal Ganglia Photothrombotic Infarction....Pages 93-97
Brain Volume Determination in Subarachnoid Hemorrhage Using Rats....Pages 99-102
Development of an Infarct Volume Algorithm to Correct for Brain Swelling After Ischemic Stroke in Rats....Pages 103-109
Changes in Brain Swelling and Infarction Volume over Four Days After Hypoxia Ischemia in Neonatal Rats....Pages 111-114
Zebrafish (Danio rerio) Developed as an Alternative Animal Model for Focal Ischemic Stroke....Pages 115-119
Front Matter....Pages 121-121
Signaling Pathway in Early Brain Injury after Subarachnoid Hemorrhage: News Update....Pages 123-126
Effects of Low-Dose Unfractionated Heparin Pretreatment on Early Brain Injury after Subarachnoid Hemorrhage in Mice....Pages 127-130
Lipocalin 2 and Blood-Brain Barrier Disruption in White Matter after Experimental Subarachnoid Hemorrhage....Pages 131-134
Cannabinoid Receptor Type 2 Agonist Attenuates Acute Neurogenic Pulmonary Edema by Preventing Neutrophil Migration after Subarachnoid Hemorrhage in Rats....Pages 135-139
Basal Ganglia Damage in Experimental Subarachnoid Hemorrhage....Pages 141-144
Subarachnoid Hemorrhage-Triggered Acute Hypotension Is Associated with Left Ventricular Cardiomyocyte Apoptosis in a Rat Model....Pages 145-150
The Role of Matricellular Proteins in Brain Edema after Subarachnoid Hemorrhage....Pages 151-156
Early Cerebral Infarction after Aneurysmal Subarachnoid Hemorrhage....Pages 157-159
Signaling Pathway in Cerebral Vasospasm After Subarachnoid Hemorrhage: News Update....Pages 161-165
Cerebral Infarction After Aneurysmal Subarachnoid Hemorrhage....Pages 167-172
Vascular Endothelial Growth Factor in Brain Edema Formation After Subarachnoid Hemorrhage....Pages 173-177
Perihematomal Cerebral Tissue Iron Quantification on MRI Following Intracerebral Hemorrhage in Two Human Subjects: Proof of Principle....Pages 179-183
Src Family Kinases in Brain Edema After Acute Brain Injury....Pages 185-190
Fucoidan from Fucus vesiculosus Fails to Improve Outcomes Following Intracerebral Hemorrhage in Mice....Pages 191-198
Zinc Protoporphyrin Attenuates White Matter Injury after Intracerebral Hemorrhage....Pages 199-202
Cyclooxygenase-2 Inhibition Provides Lasting Protection Following Germinal Matrix Hemorrhage in Premature Infant Rats....Pages 203-207
Intranasal IGF-1 Reduced Rat Pup Germinal Matrix Hemorrhage....Pages 209-212
PAR-1, -4, and the mTOR Pathway Following Germinal Matrix Hemorrhage....Pages 213-216
Intranasal Osteopontin for Rodent Germinal Matrix Hemorrhage....Pages 217-220
Front Matter....Pages 221-221
Novel Imaging Markers of Ischemic Cerebral Edema and Its Association with Neurological Outcome....Pages 223-226
Front Matter....Pages 221-221
Methylene Blue Ameliorates Ischemia/Reperfusion-Induced Cerebral Edema: An MRI and Transmission Electron Microscope Study....Pages 227-236
Acute Hyperglycemia Is Associated with Immediate Brain Swelling and Hemorrhagic Transformation After Middle Cerebral Artery Occlusion in Rats....Pages 237-241
The Effects of Clinically Relevant Hypertonic Saline and Conivaptan Administration on Ischemic Stroke....Pages 243-250
Acute Hyperglycemia Does Not Affect Brain Swelling or Infarction Volume After Middle Cerebral Artery Occlusion in Rats....Pages 251-255
ZNT-1 Expression Reduction Enhances Free Zinc Accumulation in Astrocytes After Ischemic Stroke....Pages 257-261
Osteopontin-Rac1 on Blood-Brain Barrier Stability Following Rodent Neonatal Hypoxia-Ischemia....Pages 263-267
Early Use of Statin in Patients Treated with Alteplase for Acute Ischemic Stroke....Pages 269-275
Front Matter....Pages 277-277
Decreasing the Cerebral Edema Associated with Traumatic Intracerebral Hemorrhages: Use of a Minimally Invasive Technique....Pages 279-284
Reduction of Cerebral Edema via an Osmotic Transport Device Improves Functional Outcome after Traumatic Brain Injury in Mice....Pages 285-289
Deferoxamine Attenuated the Upregulation of Lipocalin-2 Induced by Traumatic Brain Injury in Rats....Pages 291-294
Cerebrovascular Time Constant in Patients with Head Injury....Pages 295-297
Thrombin Preconditioning in Surgical Brain Injury in Rats....Pages 299-304
Valproic Acid Pretreatment Reduces Brain Edema in a Rat Model of Surgical Brain Injury....Pages 305-310
Epsilon Aminocaproic Acid Pretreatment Provides Neuroprotection Following Surgically Induced Brain Injury in a Rat Model....Pages 311-315
Correlation Between Subacute Sensorimotor Deficits and Brain Edema in Rats after Surgical Brain Injury....Pages 317-321
Propofol Pretreatment Fails to Provide Neuroprotection Following a Surgically Induced Brain Injury Rat Model....Pages 323-327
Front Matter....Pages 329-329
Intraventricular Injection of Noncellular Cerebrospinal Fluid from Subarachnoid Hemorrhage Patient into Rat Ventricles Leads to Ventricular Enlargement and Periventricular Injury....Pages 331-334
The Effect of Gender on Acute Hydrocephalus after Experimental Subarachnoid Hemorrhage....Pages 335-339
Effects of Gender and Estrogen Receptors on Iron-Induced Brain Edema Formation....Pages 341-345
Elevated Cytoplasmic Free Zinc and Increased Reactive Oxygen Species Generation in the Context of Brain Injury....Pages 347-353
Front Matter....Pages 329-329
Role of Protease-Activated Receptor-1 in Glioma Growth....Pages 355-360
Minocycline Attenuates Iron-Induced Brain Injury....Pages 361-365
Effect of Gender on Iron-induced Brain Injury in Low Aerobic Capacity Rats....Pages 367-371
Acetazolamide Attenuates Thrombin-Induced Hydrocephalus....Pages 373-377
Effects of Aerobic Capacity on Thrombin-Induced Hydrocephalus and White Matter Injury....Pages 379-384
Back Matter....Pages 385-399