Brain Edema X: Proceedings of the Tenth International Symposium San Diego, California, October 20–23, 1996

Front Matter....Pages I-XII
Glutamate Uptake and Na,K-ATPase Activity in Rat Astrocyte Cultures Exposed to Ischemia....Pages 1-3
The Role of Calcium Ion in Anoxia/Reoxygenation Damage of Cultured Brain Capillary Endothelial Cells....Pages 4-7
Hypoxia Modulates Free Radical Formation in Brain Microvascular Endothelium....Pages 8-11
Increase in Surface Expression of ICAM-1, VCAM-1 and E-Selectin in Human Cerebromicrovascular Endothelial Cells Subjected to Ischemia-Like Insults....Pages 12-16
Assessment of the Relationship Between Ischemic Damage and Brain Swelling in Frozen Brain Slices....Pages 17-19
Brain Edema Associated with Progressive Selective Neuronal Death or Impending Infarction in the Cerebral Cortex....Pages 20-22
Blood Volume and Flow Velocity Through Parenchymal Microvessels in Ischemic Brain Edema of Rats....Pages 23-26
Hyperglycemia and the Vascular Effects of Cerebral Ischemia....Pages 27-29
The Effect of Non-Competitive N-Methyl-D-Aspartate Receptor Antagonism on Cerebral Oedema and Cerebral Infarct Size in the Aging Ischaemic Brain....Pages 30-33
Effects of Hyperglycemia on Cerebral Blood Flow and Edema Formation After Carotid Artery Occlusion in Fischer 344 Rats....Pages 34-36
The Mechanism of Free Radical Generation in Brain Capillary Endothelial Cells After Anoxia and Reoxygenation....Pages 37-39
Mannitol Decreases ICP but Does Not Improve Brain-Tissue pO 2 in Severely Head-Injured Patients with Intracranial Hypertension....Pages 40-42
A Chronological Evaluation of Experimental Brain Infarct by Diffusion-Mapping and Magnetization Transfer Contrast Imaging....Pages 43-45
Ultrastructure of Astrocytes Associated with Selective Neuronal Death of Cerebral Cortex After Repeated Ischemia....Pages 46-49
Heterogenous Distribution of Early Energy Failure in Experimental Focal Ischemia of the Cat Brain....Pages 50-52
Leukocyte-Endothelium Interactions in Global Cerebral Ischemia....Pages 53-55
Selective Impairments of Mitochondrial Respiratory Chain Activity During Aging and Ischemic Brain Damage....Pages 56-58
Regional Differences in the Cerebrovascular Reserve Following Acute Global Ischemia in Rabbits....Pages 59-61
Edema Formation Exacerbates Neurological and Histological Outcomes After Focal Cerebral Ischemia in CuZn-Superoxide Dismutase Gene Knockout Mutant Mice....Pages 62-64
Therapeutic Dose and Timing of Administration of RNA Synthesis Inhibitors for Preventing Cerebral Vasospasm after Subarachnoid Hemorrhage....Pages 65-67
Traumatic Brain Swelling in Head Injured Patients: Brain Edema or Vascular Engorgement?....Pages 68-70
Evaluation of Homeostatic Changes in CSF Circulation: In vivo Analysis of the Effect of Neurotransmitter Accumulation in the Extracellular Space Following Transient Global Ischemia....Pages 71-74
Detection of Brain Atrophy Following Traumatic Brain Injury Using Gravimetric Techniques....Pages 75-77
Altered Brain Oxygen Extraction with Hypoxia and Hypotension Following Deep Hypothermic Circulatory Arrest....Pages 78-79
Posttraumatic Edema in the Corpus Callosum Shown by MRI....Pages 80-83
Detection of Lipid Peroxidation and Hydroxyl Radicals in Brain Contusion of Rats....Pages 84-86
Time Course of Tissue Elasticity and Fluidity in Vasogenic Brain Edema....Pages 87-90
The Penumbra Zone of a Traumatic Cortical Lesion: a Microdialysis Study of Excitatory Amino Acid Release....Pages 91-93
Assessment of Regional Cortical Blood Flow Following Traumatic Lesion of the Brain....Pages 94-95
Comparison of the Interleukin-6 and Interleukin-10 Response in Children After Severe Traumatic Brain Injury or Septic Shock....Pages 96-97
Changes of MPO Activity and Brain Water Accumulation in Traumatic Brain Injury Experiments....Pages 98-101
Hemodynamic Depression and Microthrombosis in the Peripheral Areas of Cortical Contusion in the Rat: Role of Platelet Activating Factor....Pages 102-105
Characterisation of Brain Edema Following “Controlled Cortical Impact Injury” in Rats....Pages 106-108
The Role of Adenosine During the Period of Delayed Cerebral Swelling After Severe Traumatic Brain Injury in Humans....Pages 109-111
Near Infrared Spectroscopy (NIRS) in Patients with Severe Brain Injury and Elevated Intracranial Pressure....Pages 112-114
MRI Diffusion-Weighted Spectroscopy of Reversible and Irreversible Ischemic Injury Following Closed Head Injury....Pages 115-118
Biphasic Pathophysiological Response of Vasogenic and Cellular Edema in Traumatic Brain Swelling....Pages 119-122
Intracranial Pressure in a Modified Experimental Model of Closed Head Injury....Pages 123-125
Hypertonk/Hyperoncotic Saline Reliably Reduces ICP in Severely Head-Injured Patients with Intracranial Hypertension....Pages 126-129
Topical Application of Insulin Like Growth Factor-1 Reduces Edema and Upregulation of Neuronal Nitric Oxide Synthase Following Trauma to the Rat Spinal Cord....Pages 130-133
Prostaglandins Modulate Constitutive Isoform of Heat Shock Protein (72 kD) Response Following Trauma to the Rat Spinal Cord....Pages 134-137
The Effect of Endothelins on Ion Transport Systems in Cultured Rat Brain Capillary Endothelial Cells....Pages 138-140
Neurotoxicity of Serum Components, Comparison Between CA1 and Striatum....Pages 141-143
Role of Calcium Ions in Acidosis-Induced Glial Swelling....Pages 144-147
Glutamate Induced Astroglial Swelling — Methods and Mechanisms....Pages 148-151
Impaired Learning of Active Avoidance in Water-Intoxicated Rats....Pages 152-154
Topical Application of 5-HT Antibodies Reduces Edema and Cell Changes Following Trauma of the Rat Spinal Cord....Pages 155-158
Steroids Decrease Uptake of Carboplatin in Rat Gliomas — Uptake Improved by Intracarotid Infusion of Bradykinin Analog, RMP-7....Pages 159-161
Effect of Glycerol on Blood Flow Distribution in Tumoral and Peritumoral Brain Tissue....Pages 162-164
Assessment of Vasoreactivity in Brain Edema by Acetazolamide Activation SPECT and PET....Pages 165-166
Tumor Specific Contrast Enhancement Study of Mn-Metalloporphyrin (ATN-10) — Comparison of Rat Brain Tumor Model, Cytotoxic and Vasogenic Edema Models....Pages 167-169
Apparent Diffusion Coefficient (ADC) and Magnetization Transfer Contrast (MTC) Mapping of Experimental Brain Tumor....Pages 170-172
The Origin of Lactate in Peritumoral Edema as Measured by Proton-Magnetic Resonance Spectroscopic Imaging....Pages 173-175
Neuroprotective Properties of a Novel Antioxidant (U-101033E) with Improved Blood-Brain Barrier Permeability in Focal Cerebral Ischemia....Pages 176-178
Effect of α-Trinositol on Swelling and Damage of Glial Cells by Lactacidosis and Glutamate....Pages 179-181
Effects of Lecithinized SOD on Contusion Injury in Rats....Pages 182-184
Extracellular Changes of Taurine in the Peri-Infarct Zone: Effect of Lubeluzole....Pages 185-187
Effect of Tromethamine (THAM) on Infarct Volume Following Permanent Middle Cerebral Artery Occlusion in Rats....Pages 188-190
Antioxidant, OPC-14117, Attenuates Edema Formation and Behavioral Deficits Following Cortical Contusion in Rats....Pages 191-193
OPC-21268, an Orally Effective, Nonpeptide Arginine Vasopressin V 1 Receptor Antagonist Reduces Vasogenic Brain Edema....Pages 194-197
Treatment of Acute Intracranial Hypertension with RU 51599, a Selective Kappa Opioid Agonist....Pages 198-201
The Effect of Nitric Oxide Inhibition on Ischemic Brain Edema....Pages 202-205
Blood-Brain Barrier Disturbances After rt-PA Treatment of Thromboembolic Stroke in the Rat....Pages 206-208
The Effect of Dotarizine (Ca 2+ Channel Blocker) on Cerebral Vessel Reactivity in Animals Subjected to Hyperventilation and Anoxia....Pages 209-211
Substance P Endopeptidase Activity in the Rat Spinal Cord Following Injury: Influence of the New Anti-Oxidant Compound H 290/51....Pages 212-215
Benzodiazepine Receptors Influence Spinal Cord Evoked Potentials and Edema Following Trauma to the Rat Spinal Cord....Pages 216-219
Induction of Matrix Metalloproteinases Following Brain Injury in Rats....Pages 220-221
Expression of Annexin and Annexin-mRNA in Rat Brain Under Influence of Steroid Drugs....Pages 222-224
Role of Protein Kinase C in Acidosis Induced Glial Swelling —Current Understanding....Pages 225-227
Dependence of Basal Cerebral Blood Flow and Cerebral Vascular Resistance in Spontaneously Hypertensive Rats Upon Vasoconstrictor Prostanoids....Pages 228-230
The Mechanism of Reversible Osmotic Opening of the Blood-Brain Barrier: Role of Intracellular Calcium Ion in Capillary Endothelial Cells....Pages 231-233
Blood-Brain Barrier Disruption, Edema Formation, and Apoptotic Neuronal Death Following Cold Injury....Pages 234-236
Blood-Brain Barrier Disruption, HSP70 Expression and Apoptosis Due to 3-Nitropropionie Acid, a Mitochondrial Toxin....Pages 237-239
Blood-Brain Barrier Breakdown Occurs Early After Traumatic Brain Injury and is not Related to White Blood Cell Adherence....Pages 240-242
Acute Blood-Brain Barrier Changes in Experimental Closed Head Injury as Measured by MRI and Gd-DTPA....Pages 243-246
Transport of Human β-Amyloid Peptide Through the Rat Blood-Brain Barrier After Global Cerebral Ischemia....Pages 247-249
Enhanced Brain Opioid Receptor Activity Precedes Blood-Brain Barrier Disruption....Pages 250-253
The Effects of Methylmethacrylate’s Hyperthermic Polymerization on Cerebral Vascular Permeability....Pages 254-256
Intraischemic Hypothermia During Pretreatment with Sublethal Ischemia Reduces the Induction of Ischemic Tolerance in the Gerbil Hippocampus....Pages 257-259
The Relationship Between Brain Temperature and Neutrophil Accumulation After Traumatic Brain Injury in Rats....Pages 260-261
Effect of Mild and Moderate Hypothermia on the Acidosis-Induced Swelling of Glial Cells....Pages 262-264
Cerebral Vascular Response to Hypertonic Fluid Resuscitation in Thermal Injury....Pages 265-266
Morphologic Analysis of the Cerebral Microcirculation After Thermal Injury and the Response to Fluid Resuscitation....Pages 267-268
Role of Neurochemicals in Brain Edema and Cell Changes Following Hyperthermic Brain Injury in the Rat....Pages 269-274
Acute Heat Stress Induces Edema and Nitric Oxide Synthase Upregulation and Down-Regulates mRNA Levels of the NMDAR1, NMDAR2A and NMDAR2B Subunits in the Rat Hippocampus....Pages 275-278
Choroid Plexus Ion Transporter Expression and Cerebrospinal Fluid Secretion....Pages 279-281
Effect of Infection Brain Edema on NMDA Receptor Binding in Rat Brain in vivo ....Pages 282-284
The Rapid Flow of Cerebrospinal Fluid from Ventricles to Cisterns via Subarachnoid Velae in the Normal Rat....Pages 285-287
Quantitative Analysis of Brain Edema Resolution into the Cerebral Ventricles and Subarachnoid Space....Pages 288-290
Responses of Cerebral Blood Flow Regulation to Activation of the Primary Somatosensory Cortex During Electrical Stimulation of the Forearm....Pages 291-292
A New Model of Spinal Cord Edema....Pages 293-295
Assessment of the CAMINO Intracranial Pressure Device in Clinical Practice....Pages 296-298
Back Matter....Pages 299-302