Bradykinin and Related Kinins: Cardiovascular, Biochemical, and Neural Actions

Front Matter....Pages i-xxv
In Vitro Investigations on Some Components of the Kinin System (Kininogen, Serum Kallikrein, Hageman Factor), and Their Interaction....Pages 1-10
Observations on Plasma Kinin Forming Enzymes....Pages 11-14
Liberation Mechanisms of Kinins in Bovine Plasma....Pages 15-22
Application of Water-Insoluble Complexes of Kininogenases, Inhibitors and Kininases to Kinin Research....Pages 23-30
Kinin Formation in Human Blood Serum Induced by Cooling and by Heat Aggregated Human Gamma Globulin Preparations....Pages 31-37
Kinin Metabolism in Normal and Malignant Leucocytes....Pages 39-45
Optical Activity and Conformation of Bradykinin and Related Peptides....Pages 47-56
Studies on Antibody to Bradykinin....Pages 57-64
Partial Purification of Rat Urinary Kininogenase and its Reactions with Active Center Reagents of Trypsin....Pages 65-75
Kininogenic and Oxytocic Properties of Rat Pancreatic Juice....Pages 77-80
Bradykinin-Potentiating Peptides from the Venom of Bothrops Jararaca ....Pages 81-87
Active Pharmacological Principle Released by Different Enzymatic Preparations from Bothrops Jararaca Plasma....Pages 89-99
Structure of Bradykinin Potentiating Peptides from the Venom of Agkistrodon halys blomhoffii ....Pages 101-105
Biochemistry of Kinin-Releasing Enzymes in the Venom of the Viper Bitis Gabonica and of the Lizard Heloderma Suspectum....Pages 107-116
The Occurrence in Plasma of a Protein with Kinin-Like Activity....Pages 117-122
The Isolation and Partial Characterization of Kinin-Forming Enzymes and Other Active Components From Human Plasma....Pages 123-130
Modification of the Reactivity of Guinea-Pig Seminal Vesicles to Angiotensin and Tyramine by some Microsomal Enzyme Inducers....Pages 131-136
A Kinin-Like Forming Enzyme in Saliva Presenting a Potent Oxytocic Activity....Pages 137-140
Significance of Kinins in The Coronary Circulation....Pages 141-148
Comparative Cardiac Effects of Angiotensin, Eledoisin and Physalaemin....Pages 149-156
Effects of Bradykinin, Eledoisin, and Physalaemin on Cardiovascular Dynamics....Pages 157-170
Eledoisin and Bradykinin. Their Effect on the Circulation in the Skeletal Muscles and in the Skin, in Man....Pages 171-173
Response of the Circulatory System to Bradykinin and Related Peptides: A Specific Kinin Assay....Pages 175-181
An Analysis of Reserpine-Induced Hypersensitivity of Rabbit Aortic Strip to Eledoisin....Pages 183-189
Hemorrhagic Snake Venoms and Kallikrein Inhibitors as Tools to Study Factors Determining the Integrity of the Vessel Wall....Pages 191-199
Systemic Arterial Pressure Variations Induced by the Stimulation of Bradykinin-Sensitive Vascular Receptors....Pages 201-212
Activity Ratio Between Intestinal and Cardiovascular Actions of Caerulein and Related Substances in the Anaesthetized Dog....Pages 213-220
Plasma Kininogen Level in Myocardial Infarction....Pages 221-224
Characterization of Pre-Kallikrein Activity in Developing Transplanted Mammalian Tumors....Pages 225-237
Microcirculatory Actions of Polypeptides and Their Use in the Treatment of Experimental Shock....Pages 239-247
An Electron Microscopic Study of the Vascular Endothelium as a Site for Bradykinin and Adenosine-5′-Triphosphate Inactivation in Rat Lung....Pages 249-261
Inactivation of Bradykinin in Rat Lung....Pages 263-271
Depletion of Kininogen I by Stem Bromelain and Its Significance Prevention of Adrenalin-Induced Pulmonary Edema in Rats....Pages 273-282
The Mechanism of Bradykinin Edema....Pages 283-289
Enzymatic System and the Formation of a Vasopressor Albumin in the Incubated Plasma....Pages 291-306
New Vasoactive Polypeptides Isolated from Ox Alfa-2 Macroglobulin....Pages 307-313
Metabolism of 14 C-Bradykinin in Man....Pages 315-319
Kinin Release during Cold Vasodilation in Man....Pages 321-328
Kinin Release Associated with the Gastro-Intestinal Tract....Pages 329-339
The Significance of Plasmakinins in Intestinal Obstruction and Peritonitis....Pages 341-342
In Vivo Investigations on the Role of the Kinin System in Tissue Injury and Shock Syndromes....Pages 343-353
Indirect Evidence Against a Major Role of Kinins in Tourniquet-Shock by Use of Carboxypeptidase B....Pages 355-361
Kininogen Content of Plasma in Man and Animal During Gestation....Pages 363-367
Kininolytic Activity of Human Amniotic Fluid....Pages 369-375
Local Ischemia as a Kininogen Depressant: Effect of Cortisone, Taurine and a Kallikrein Inhibitor....Pages 377-383
Permeability Factor Dilution and Kinin Formation by Contaminating CSF with Plasma in Man....Pages 385-392
Eledoisin and Fibrinolysis in Man....Pages 393-396
The Clinical Studies of the Kallikrein-Kinin System with Special Reference to Bronchial Asthma....Pages 397-401
Activation of the Plasma Kallikrein System During Myocardial Ischemia....Pages 403-410
The Pathophysiological Role of Kallikrein and Histamine in Malaria....Pages 411-423
Cancer Chemotherapy and Blood Kininogen Content....Pages 425-433
The Inhibition by Trasylol of Bradykininases in Dog’s Blood....Pages 435-436
The Kinin Potentiating Action of Some Local Anesthetics....Pages 437-446
The Antikinin Action of Some Antihistaminic Drugs on the Isolated Guinea-Pig Ileum, Rat Uterus and Blood Pressure of the Anesthetized Dog....Pages 447-452
The Inhibition of Guinea-Pig Plasma Kallikrein by Amidines....Pages 453-460
Kinins and Anti-Inflammatory Drugs....Pages 461-469
Plasma Kinin Formation in Rheumatoid Arthritis....Pages 471-475
Interference of Carrageenin, Non-Steroidal Anti-Inflammatory Drugs and Protease Inhibitors with the Kallikrein-Kinin System....Pages 477-485
Investigation of Pharmacological Agents Released in Human Cutaneous Inflammation Using a Direct Perfusion Method....Pages 487-491
Evidence For and Against the Kinins as Endogenous Mediators of Arthritis....Pages 493-501
Histamine, Bradykinin and Serotonin Potentiation by the Slow Reacting Substance in Anaphylaxis....Pages 503-505
Direct Evidence on the Participation of Bradykinin and Related Kinins in Acute Inflammatory Reactions....Pages 507-523
The Two Distinct Phases of Inflammatory Response in the Dog’s Knee Joint....Pages 525-533
On the Influence of Plasma Kallikrein Inhibitors and Antihistaminics on Formalin Edema of the Rat Paw (Prepared Discussion Remark)....Pages 535-538
The Release of Kinins as the Result of an Antigen-Antibody Reaction in Trypanosomiasis....Pages 539-542
Activation of Central Pain Pathways by Bradykinin and the Effect of Analgesics....Pages 543-545
Stimulation of Paravascular Intracranial Receptors by Bradykinin and Kallidin....Pages 547-554
The Influence of Intracranially Applied Bradykinin on the Rest Tremor in Rats....Pages 555-560
The Release of Vasopressin by a Direct Central Action of Bradykinin....Pages 561-570
Peptides and the Sympathetic Nervous System....Pages 571-589
Some Actions of Bradykinin and Related Peptides on Autonomic Ganglion Cells....Pages 591-599
Bradykinin and Catecholamines Release from the Adrenal Medulla of the Cat: A Possible Indirect Reflex Mechanism....Pages 601-608
Release of the Antidiuretic Hormone by Bradykinin in Rats....Pages 609-614
Kallikrein Granules in the Submaxillary Gland and Pancreas....Pages 615-623
Kinin Formation in the Active Submandibular Salivary Gland....Pages 625-628
Nervous Regulation of Kallikrein and Sialotonin Secretion....Pages 629-633
Effects of Intraventricular Injections of Bradykinin on Blood Glucose Levels in the Rabbit....Pages 635-639
Back Matter....Pages 641-651