Bone Marrow Transplantation (Vademecum)

Front Cover......Page 1
Inside Cover......Page 2
Preface......Page 4
History of Bone Marrow Transplantation......Page 5
Bone Marrow Transplantation Unit......Page 10
Patient and Donor Evaluation......Page 16
Bone Marrow Transplantation from Alternate Donors......Page 25
Costs of Care for Bone Marrow Transplantations for Malignant Hematopoietic Diseases......Page 31
Transplantation Procedures......Page 40
Transfusions......Page 53
Hematopoietic Progenitor Stem Cells......Page 68
Purging of Bone Marrow and Peripheral Blood Stem Cells......Page 75
Marrow Processing and Cryopreservation......Page 85
Conditioning (Preparative) Regimens......Page 92
Total Body Irradiation......Page 107
High-Dose Alkylating Agent Pharmacology/Toxicity......Page 121
MHC and Bone Marrow Transplantation......Page 129
Aplastic Anemia......Page 146
Acute Myeloid Leukemia—AML......Page 154
Adult Acute Lymphoblastic Leukemia (age >15 years old)......Page 165
Chronic Myeloid Leukemia—CML......Page 180
Chronic Lymphocytic Leukemia......Page 185
Multiple Myeloma......Page 191
Bone Marrow Transplantation in Lymphomas......Page 202
Adult Solid Tumors......Page 227
Bone Marrow Transplantation for Pediatric Malignancy......Page 245
Hereditary Disorders of the Immune System Treatable by Bone Marrow Transplantation......Page 259
Lysosomal and Peroxisomal Storage Diseases......Page 266
The Clinical Management of Thalassemia Patients Undergoing Bone Marrow Transplantation Bone......Page 278
Bone Marrow Transplantation for Sickle Cell Anemia......Page 287
Graft Failure......Page 299
Minimal Residual Disease......Page 307
Relapse After Bone Marrow Transplantation......Page 316
Diagnosis and Management of Complications Related to Long- Term Venous Access Devices......Page 320
Nutritional Support in Bone Marrow Transplant Recipients......Page 330
Management of Pain in the Bone Marrow Transplant Patient......Page 344
Cardiovascular Support......Page 367
Respiratory Support......Page 383
Disorders of Renal Function and Electrolytes......Page 395
Growth Factors......Page 410
Infection Prophylaxis in Bone Marrow Transplant Recipients— Myths, Legends and Microbes......Page 422
Approaches to Management of Invasive Fungal Infections in Bone Marrow Transplant Recipients......Page 436
Virus Infections Complicating Bone Marrow Transplantation......Page 453
Graft-Versus-Host Disease......Page 461
Graft-Versus-Leukemia Effect of Allogeneic BMT......Page 481
Regimen Related Toxicity— First 30 Days Early Toxicity of High-Dose Therapy......Page 485
Delayed Complications......Page 496
Outpatient Management of Marrow and Blood Stem Cell Transplant Patients......Page 504
Gene Therapy......Page 512
Medications......Page 522
Appendix I: Organizations Relevant to Bone Marrow Transplantation......Page 545
Appendix II: Allogeneic BMT Patient Pre-admission Evaluation......Page 552
Appendix III: Leukocyte Antigens......Page 555
Appendix IV: NCI Common Toxicity Criteria......Page 561