Biosensors: Materials and Applications

front-matter
	Table of Contents
	Preface
1
	Applications of Aptasensors in Health Care
	1. Introduction
	2. Aptamer-based sensing platform
	3. Immobilization of recognition molecules
	4. Design and strategies of aptasensors
	5. Application of aptasensor for small molecules
		5.1 Aptasensor for pesticide
		5.2 Aptasensor for small molecules (Cocaine and Adenosine)
		5.3 Aptasensor for Lysozyme
		5.4 Application of aptasensor for bacterial, viral and protozoan
		5.5 Application of aptasensor for non-infectious disease
	6. Future prospects
	References
2
	Applications of Molecularly Imprinted Polymers to Genobiosensors
	1. Introduction
		1.1 Molecularly Imprinted Polymers
		1.2 Precursors of MIPs
		1.3 Approaches to MIP synthesis
		1.4 Applications of MIPs
	2. Biosensors
		2.1 Introduction to Biosensors
		2.2 Components of Biosensor
		2.3 Bioreceptors
		2.2.2 Transducers
		2.2.3 Amplifier, electronics and interface or display
	3. Immobilization Matrices for Biosensors
	4. Molecularly Imprinted Polymers based Geno-biosensors:
	Conclusion
	Acknowledgement
	References
3
	Application of Functional Metal Nanoparticles for Biomarker Detection
	1. Background
	2. Metal nanomaterials
		2.1 Synthesis
		2.2 Characterization methods
		2.3 Biomedical applications
	3. Functional metal nanoparticles
	4. Tumour markers and targeting of nanoparticles
	5. Sensing and imaging applications of metal nanoparticles
		5.1 Gold nanoparticles
		5.2 Silver nanoparticles
		5.3 Platinum nanoparticles
		5.4 Palladium nanoparticles
		5.5 Other metal nanoparticles
	6. Techniques used for biosensing and imaging applications
		6.1 Fluorescence sensing techniques
		6.2 ELISA technique
		6.3 SERS technique
		6.4 In vivo imaging
	7. Safety issues of metal nanoparticles
	Conclusions
	References
4
	Layered Double Hydroxide Based Biosensors
	1. Introduction
	2. Prominent and unique features of layered double hydroxide modified electrodes
	3. Layered double hydroxide based biosensors
	4. Fabrication of LDH based biosensors
		4.1 Solvent casting
		4.2 Layer by layer assembly
		4.3 Electrogeneration (electrosynthesis)
		4.4 Carbon paste electrode
	5. Electroanalytical applications of LDH based biosensors
		5.1 Glucose oxidase based biosensor
		5.2 Tyrosinase based LDH biosensors
		5.3 Heme-based LDH biosensors
		5.3.1 Hemoglobin (Hb) based LDH biosensors
		5.3.2 Myoglobin (Mb) based LDH biosensors
		5.3.3 Cytochrome c (Cyt c) based LDH biosensors
		5.3.4 Horseradish peroxidase (HRP) based LDH biosensors
		5.4 Acetylcholinesterase (AChE) based LDH biosensors
	6. Miscellaneous
	Conclusion and future perspective:
	Acknowledgments
	References
5
	Electrochemical Nanobiosensors for Cancer Diagnosis
	1. Introduction
	2. Lung Cancer
		2.1 Antibody-based biosensor
		2.2 Nucleic acid-based biosensor
		2.3 Biomimetic based biosensor
		2.4 Other
	3. Breast Cancer
		3.1 Enzyme-based biosensor
		3.2 Antibody-based biosensor
		3.3 Nucleic acid-based biosensor
		3.4 Biomimetic biosensor
	4. Prostate Cancer
		4.1 Enzyme-based biosensor
		4.2 Antibody-based biosensor
		4.3 Lectin-based biosensor
		4.4 Nucleic acid-based biosensor
		4.5 Biomimetic biosensor
		4.6 Phage-based biosensor
		4.7 Fabricated biochips
	Aptamer-nanospears Au/Au electrode
	5. Colorectal Cancer
		5.1 Enzyme-based biosensor
		5.2 Antibody-based biosensor
		5.3 Nucleic acid-based biosensor
		5.4 Biomimetic biosensor
	Conclusion and Future Prospective
	References
6
	Role of Nanoparticles in Combating Infections
	1. Introduction
	2. Challenges for the treatment of microbial infections
	3. Role of nanotechnology in therapeutic delivery of antimicrobial agents
	4. Polymeric-based nanoparticles as an antimicrobial agents
		4.1 Metallic nanoparticles as antibacterial agents
		4.1.1 Metallic oxides nanoparticles as antimicrobial agents
		4.1.2 Silver nanoparticles as antimicrobial agents
		4.1.3 Zinc oxide nanoparticles as antimicrobial agents
		4.1.4 Gold nanoparticles as antimicrobial agents
		4.1.5 Copper oxide nanoparticles as antimicrobial agents
		4.1.6 Metal-halogen complex-based nanoparticles as antimicrobial agents
		4.2 Chitosan-based nanoparticles as antimicrobial agents
	5. Polymeric-based nanoparticles as microbial diagnostic agents
	6. Recent advances in intracellular delivery of nanoparticle-based antibiotics
		6.1 Amphotericin B
		6.2 Aminoglycosides
		6.3 Beta-lactam antibiotics
		6.4 Tetracycline antibiotics
		6.5 Fluoroquinolone antibiotics
		6.6 Macrolide antibiotics
		6.7 Cephalosporins
		6.8 Nanoparticle-based antibacterial vaccination
	Conclusion
	References
7
	Theranostic Application of Nanoparticulated Systems: Present and Future Prospects
	1. Introduction
	2. Types of nanocarriers
	3. Targeted delivery and control release
	4. Merits of nanotechnology based therapeutics
	5. Mechanism of action of nanotechnology based therapeutic agents
	6. Demerits of nanotechnology based therapeutics
	7. Current nanotechnology based therapeutics for clinical trails
	8. Future prospects of nanotechnology
	Conclusion
	References
8
	Enzymatic Biosensor for in vivo Applications
	1. Introduction
	2. Biosensors: definition and classification
	3. Biosensors: Michaelis–Menten model in amperometric biosensors
	4. Biosensors in in vivo applications: important issues
	5. Sensitivity, limit of detection, limit of quantification and linear range
	6. Selectivity: interference of endogenous reducing agents
	7. Oxygen deficit
	8. Biocompatibility and long-term stability
	Conclusions
	References
back-matter
	Keyword Index
	About the Editors