BIOS Instant Notes in Immunology

BOOK COVER......Page 1
TITLE......Page 4
COPYRIGHT......Page 5
CONTENTS......Page 6
ABBREVIATIONS......Page 9
PREFACE......Page 11
KEY TO CELL SYMBOLS......Page 12
A1 THE NEED......Page 14
A2 EXTERNAL DEFENSES......Page 15
A3 IMMUNE DEFENSE......Page 18
A4 ANTIGENS......Page 22
A5 HEMOPOIESIS –DEVELOPMENT OF BLOOD CELLS......Page 25
B1 CELLS OF THE INNATE IMMUNE SYSTEM......Page 28
B2 MOLECULES OF THE INNATE IMMUNE SYSTEM......Page 36
B3 RECOGNITION OF MICROBES BY THE INNATE IMMUNE SYSTEM......Page 46
B4 INNATE IMMUNITY AND INFLAMMATION......Page 49
C1 LYMPHOCYTES......Page 54
C2 LYMPHOID ORGANS AND TISSUES......Page 61
C3 MUCOSA-ASSOCIATED LYMPHOID TISSUES......Page 66
C4 LYMPHOCYTE TRAFFIC AND RECIRCULATION......Page 69
C5 ADAPTIVE IMMUNITY AT BIRTH......Page 72
D1 ANTIBODY STRUCTURE......Page 74
D2 ANTIBODY CLASSES......Page 78
D3 GENERATION OF DIVERSITY......Page 81
D4 ALLOTYPES AND IDIOTYPES......Page 91
D5 MONOCLONAL ANTIBODIES......Page 93
D6 ANTIGEN/ANTIBODY COMPLEXES (IMMUNE COMPLEXES)......Page 96
D7 IMMUNOASSAY......Page 100
D8 ANTIBODY FUNCTIONS......Page 106
E1 THE B CELL RECEPTOR COMPLEX, CO-RECEPTORS AND SIGNALING......Page 112
E2 B CELL ACTIVATION......Page 115
E3 THE CELLULAR BASIS OF THE ANTIBODY RESPONSE......Page 121
E4 ANTIBODY RESPONSES IN DIFFERENT TISSUES......Page 125
F1 THE ROLE OF T CELLS IN IMMUNE RESPONSES......Page 128
F2 T CELL RECOGNITION OF ANTIGEN......Page 130
F3 SHAPING THE T CELL REPERTOIRE......Page 137
F4 T CELL ACTIVATION......Page 140
F5 CLONAL EXPANSION AND DEVELOPMENT OF EFFECTOR FUNCTION......Page 145
F6 CELL-MEDIATED IMMUNITY IN CONTEXT......Page 151
G1 OVERVIEW......Page 154
G2 CENTRAL AND PERIPHERAL TOLERANCE......Page 158
G3 ACQUIRED TOLERANCE......Page 162
G4 REGULATION BY ANTIGEN AND ANTIBODY......Page 165
G5 GENES,T HELPER CELLS, CYTOKINES AND THE NEUROENDOCRINE SYSTEM......Page 168
H1 THE MICROBIAL COSMOS......Page 172
H2 IMMUNITY TO DIFFERENT ORGANISMS......Page 175
H3 PATHOGEN DEFENSE STRATEGIES......Page 180
I1 PRINCIPLES OF VACCINATION......Page 184
I2 IMMUNIZATION......Page 187
I3 ANTIGEN PREPARATIONS......Page 190
I4 VACCINES TO PATHOGENS AND TUMORS......Page 194
J1 DEFICIENCIES IN THE IMMUNE SYSTEM......Page 196
J2 PRIMARY/CONGENITAL (INHERITED)IMMUNODEFICIENCY......Page 198
J3 SECONDARY (ACQUIRED) IMMUNODEFICIENCY......Page 202
J4 DIAGNOSIS AND TREATMENT OF IMMUNODEFICIENCY......Page 205
K1 DEFINITION AND CLASSIFICATION......Page 210
K2 IgE-MEDIATED (TYPE I) HYPERSENSITIVITY: ALLERGY......Page 212
K3 IgG AND IgM-MEDIATED (TYPE II) HYPERSENSITIVITY......Page 217
K4 IMMUNE-COMPLEX-MEDIATED (TYPE III) HYPERSENSITIVITY......Page 221
K5 DELAYED (TYPE IV) HYPERSENSITIVITY......Page 223
L1 THE SPECTRUM AND PREVALENCE OF AUTOIMMUNITY......Page 228
L2 FACTORS CONTRIBUTING TO THE DEVELOPMENT OF AUTOIMMUNE DISEASE......Page 230
L3 AUTOIMMUNE DISEASES – MECHANISMS OF DEVELOPMENT......Page 235
L4 DISEASE PATHOGENESIS – EFFECTOR MECHANISMS......Page 240
L5 DIAGNOSIS AND TREATMENT OF AUTOIMMUNE DISEASE......Page 244
M1 THE TRANSPLANTATION PROBLEM......Page 248
M2 TRANSPLANTATION ANTIGENS......Page 250
M3 REJECTION MECHANISMS......Page 253
M4 PREVENTION OF GRAFT REJECTION......Page 256
N1 ORIGIN AND HOST DEFENSE AGAINST TUMORS......Page 262
N2 TUMOR ANTIGENS......Page 263
N3 IMMUNE RESPONSES TO TUMORS......Page 266
N4 IMMUNODIAGNOSIS......Page 269
N5 CYTOKINE AND CELLULAR IMMUNOTHERAPY OF TUMORS......Page 272
N6 IMMUNOTHERAPY OF TUMORS WITH ANTIBODIES......Page 275
N7 TUMOR VACCINES......Page 279
O1 OVERVIEW......Page 282
O2 IMMUNE CELLS AND MOLECULES ASSOCIATED WITH THE REPRODUCTIVE TRACTS......Page 284
O3 FUNCTIONAL EFFECTS OF SEX HORMONES ON THE IMMUNE SYSTEM......Page 292
P1 OVERVIEW......Page 296
P2 DEVELOPMENTAL CHANGES IN PRIMARY LYMPHOID TISSUE AND LYMPHOCYTES WITH AGE......Page 298
P3 EFFECTS OF AGING ON INNATE IMMUNITY......Page 301
P4 THE EFFECTS OF AGING ON T CELL IMMUNITY......Page 303
P5 THE EFFECTS OF AGING ON HUMORAL IMMUNITY......Page 305
P6 IMMUNOSENESCENCE AND MORBIDITY, MORTALITY AND LONGEVITY......Page 307
FURTHER READING......Page 310
MULTIPLE CHOICE QUESTIONS......Page 312
Appendix I SELECTED CD MOLECULES......Page 328
Appendix II THE PRINCIPAL CYTOKINES......Page 330
GLOSSARY......Page 332
INDEX......Page 338