Biophysics of the Pancreatic β-Cell

Front Matter....Pages i-xii
Patch Pipettes Used for Loading Small Cells with Fluorescent Indicator Dyes....Pages 1-5
Optical Detection of Calcium Dependent ATP Release from Stimulated Medullary Chromaffin Cells....Pages 7-29
Glucose-Evoked Changes in [K + ] and [Ca 2+ ] in the Intercellular Spaces of the Mouse Islet of Langerhans....Pages 31-51
A Potassium Channel Modulated by Glucose Metabolism in Rat Pancreatic β-Cells....Pages 53-62
Glucose Suppresses ATP-Inhibited K-Channels in Pancreatic β-Cells....Pages 63-67
K-Channels in an Insulin-Secreting Cell Line: Effects of ATP and Sulphonylureas....Pages 69-76
Inhibition of K-Channels in Insulin Secreting Cells....Pages 77-82
Pharmacological Control of 86 Rb Efflux from Mouse Pancreatic Islets....Pages 83-93
Electrophysiological Measurements Show Marked Differences in the Properties of the Pancreatic β-Cell K-Channels from Albino Mice and a Strain of ob/ob (Obese) Mice....Pages 95-107
Single K-Channel Activity in Fish Islet Cells....Pages 109-123
Potassium Channels in Adrenocortical and Parathyroid Cells....Pages 125-137
Pharmacological Properties of the Chromaffin Cell Calcium Channel....Pages 139-157
Insulin Release and K + -Induced Depolarization in Mouse Pancreatic β-Cells....Pages 159-166
Calcium and Potassium Currents Recorded from Pancreatic β-Cells Under Voltage Clamp Control....Pages 167-175
Voltage-Activated Ca 2+ and K + Currents in an Insulin-Secreting Cell Line (RINm5F)....Pages 177-187
Voltage-Gated Ca Current in Pancreatic Islet β -Cells....Pages 189-193
Effects of Verapamil and Nifedipine on Glucose-Induced Electrical Activity in Pancreatic β-Cells....Pages 195-200
Stimulation of Insulin Release by Organic Calcium-Agonists....Pages 201-205
Contribution of Isotope Flux Studies to Understanding the Mechanism of the β-Cell Membrane....Pages 207-223
 22 Na + Efflux from Normal and ob/ob Mouse Islets of Langerhans....Pages 225-225
The Role of Anions in the Regulation of Insulin Secretion....Pages 227-233
Graded Spike Electrogenesis in Mouse Pancreatic β-Cells....Pages 235-246
Prediction of the Glucose-Induced Changes in Membrane Ionic Permeability and Cytosolic Ca 2+ by Mathematical Modeling....Pages 247-263
Modelling the β-Cell Electrical Activity....Pages 265-278
Insulin Secretion Studied in Islets Permeabilised by High Voltage Discharge....Pages 279-291
Regulation of Insulin Release Independent of Changes of Cytosolic Ca 2+ Concentration....Pages 293-303
The Role of Cytosolic Calcium in Insulin Secretion from a Hamster Beta Cell Line....Pages 305-316
Differential Effect of Nutrient and Non-Nutrient Secretagogues on Cytosolic Free Ca 2+ in Pancreatic Islet Cells....Pages 317-318
Relationship between Extracellular Na + and the Total Ionized Ca 2+ Content of Rat Pancreatic Islets....Pages 319-323
Mobilization of Different Pools of Glucose-Incorporated Calcium in Pancreatic β-Cells after Muscarinic Receptor Activation....Pages 325-341
Effect of the Order of Application of Neural Inputs on Insulin Secretion....Pages 343-349
Muscarinic Receptors and the Control of Glucose-Induced Electrical Activity in the Pancreatic β-Cell....Pages 351-358
Electrophysiological Evidence for Histaminergic Modulation of Pancreatic β-Cell Function....Pages 359-365
Effect of Melatonin on Insulin Secretion from Isolated Rat Islets of Langerhans....Pages 367-368
Calcium Regulation of Membrane Fusion during Hormone Secretion....Pages 369-383
The Insulin Secretory Granule: Features and Functions in Common with Other Endocrine Granules....Pages 385-396
Effects of Monensin on Glucose-Induced Insulin Release and 45 Ca 2+ Outflow....Pages 397-401
Interdependency of Ca 2+ Availability and Cyclic AMP Generation in the Pancreatic β-Cell....Pages 403-407
Cyclic Amp-Antagonist, a Second Messenger for Insulin Action, Inhibits Glucose-Stimulated Insulin Secretion in Isolated Islets of Chinese Hamsters....Pages 409-412
Pulsatile Insulin Release and Electrical Activity from Single ob/ob Mouse Islets of Langerhans....Pages 413-425
Comparision of Stimulus-Secretion Coupling in Normal and ob/ob (Norwich Colony) Mouse Islets of Langerhans....Pages 427-427
Insulin Release, Ca 2+ Fluxes and Calmodulin Content of Pancreatic Islets in Aging Rats....Pages 429-430
Protein Carboxyl Methylation in Rat Pancreatic Islets: Possible Role in β-Cell Function....Pages 431-442
Role of Transglutaminase in Proinsulin Conversion and Insulin Release....Pages 443-446
Induction of the Glucokinase-Glucose Sensor in Pancreatic Islets of Insulinoma-Bearing Rats Following Tumor Removal....Pages 447-457
Biochemical Design Features of the Pancreatic Islet Cell Glucose-Sensory System....Pages 459-469
Back Matter....Pages 471-494