Bioorganic Chemistry in Healthcare and Technology

Front Matter....Pages iii-xi
Biogeneration of Aromas: Gamma and Delta Lactones from C-6 to C-12....Pages 1-17
Catalytic Antibodies....Pages 19-21
Inhibition of Sterol Biosynthesis by Analogues of Carbenium Ion Intermediates....Pages 23-37
Molecular Modelling and Structural Databases in Pharmaceutical Research....Pages 39-52
Supramolecular Reactivity and Catalysis of Phosphoryl Transfer....Pages 53-54
Polymer Assisted Molecular Recognition: The Current Understanding of the Molecular Imprinting Procedure....Pages 55-68
The Chemistry of Lignin Biodegradation Catabolism of Veratryl Alcohol and its Methyl Ether....Pages 69-86
Studies on Plant Tissue Culture — Synthesis and Biosynthesis of Biologically Active Substances....Pages 87-107
NMR Studies Of complexes of L. Casei Dihydrofolate Reductase with Antifolate Drugs: Multiple Conformations and Conformational Selection of Bound Rotational Isomers....Pages 109-120
Structure-Function Relationship of Gastrin Hormones: A Rational Approach to Drug Design....Pages 121-133
Indirect Modelling of Drug-Receptor Interactions....Pages 135-147
Production of Beta-Lactams: A Mixture of Organic Synthesis Processes and Enzymatic Processes....Pages 149-160
Mechanism of Action of β-Lactamases and DD-Peptidases....Pages 161-170
NMR Studies of the Enzyme Mechanisms of Vitamin B 12 Biosynthesis....Pages 171-186
Synthesis of Homochiral Pharmaceuticals using Effective Enantioselective Biocatalysts....Pages 187-196
Chemical Intervention in Catalysis by Enzymes....Pages 197-205
Immobilisation of Reductases by Two-Phase Systems and Polymer Matrices....Pages 207-211
Two Approaches in the Design of Plant Enzyme Inhibitors....Pages 213-223
The Mechanism of the Urocanase Reaction....Pages 225-231
The Microbiological Reduction/Oxidation Concept: An Approach to a Chemoenzymatic Preparation of Optically Pure Lactones and Lactonic Synthons....Pages 233-236
Effect of Temperature on Enzymatic Synthesis of Cephalosporins....Pages 237-240
Study of the Action of Hydrolases on Insoluble Substrates in Aqueous and Non-Aqueous Systems....Pages 241-244
Enzymes in Organic Solvents: Enantioselective Transesterification of Alpha-Methyl Substituted Primary Alcohols Catalyzed by a Lipase....Pages 245-248
Production of Mannitol by Leuconostoc Mesenteroides , Immobilized on Reticulated Polyurethane Foam....Pages 249-250
Synthesis of Potential Inhibitors of Vitamin D Hydroxylases....Pages 251-254
Inhibitors of Adenylosuccinate Lyase....Pages 255-258
Model Studies of the Thymidylate Synthase Reaction. Design of Mechanism-Based Potential Inhibitors of DNA Biosynthesis....Pages 259-263
Design of Plant Sterol Biosynthesis Inhibitors — Inhibition of the Steps Involved in the Removal of the 14α-Methyl Group....Pages 265-268
Biosynthesis of Melanin by Pyricularia Oryzae : Mechanism of Reduction of Polyhydroxynaphthalenes....Pages 269-272
The Predictive Value of Historical and Functional Models: Coenzyme Stereospecificity of Glucose Dehydrogenase....Pages 273-275
Modular Abiotic Amino Acid Receptors....Pages 277-280
New Alkaloids of Some Turkish Medicinal Plants....Pages 281-285
Towards Chemical Control of Gene Expression: Copper (II) and Thiols, Including Glutathione, are Powerful Reagents for Cleavage of DNA....Pages 287-290
Interaction of Reductively Methylated Lysyl-Fd Gene 5 Protein with a Negatively Charged Lanthanide Paramagnetic Macrocyclic Chelate or with Oligonucleotides using 13-C NMR....Pages 291-294
Structural and Kinetic Analysis of Flavine Adenine Dinucleotide Modification in Alcohol Oxidase from Methylotrophic Yeasts....Pages 295-298
Isolation, Characterization and Utilization of Psychrophilic Proteinases from Atlantic Cod....Pages 299-302
Conformational Analysis of Leukotrienes and Related Compounds for Mapping the Leukotriene D 4 Receptor: Application to the Design of Novel Anti-Asthma Drugs....Pages 303-307
Back Matter....Pages 309-323