Biomaterials Science: An Introduction to Materials in Medicine

CONTENTS......Page 6
Contributors......Page 10
Preface......Page 12
PART I: MATERIALS SCIENCE AND ENGINEERING......Page 22
1.2 Bulk Properties of Materials......Page 24
1.3 Surface Properties of Materials......Page 34
2.2 Metals......Page 50
2.3 Polymers......Page 63
2.4 Hydrogels......Page 73
2.5 Bioresorbable and Bioerodible Materials......Page 77
2.6 Ceramics, Glasses, and Glass-Ceramics......Page 86
2.7 Natural Materials......Page 97
2.8 Composites......Page 107
2.9 Thin Films, Grafts, and Coatings......Page 118
2.10 Fabrics......Page 131
2.11 Biologically Functional Materials......Page 137
PART II: BIOLOGY, BIOCHEMISTRY, AND MEDICINE......Page 144
3.2 Proteins: Structure, Properties, and Adsorption to Surface......Page 146
3.3 Cells: Their Surfaces and Interactions with Materials......Page 154
3.4 Tissues......Page 160
4.2 Inflammation, Wound Healing, and the Foreign Body Response......Page 178
4.3 Immunology and the Complement System......Page 186
4.4 Systemic Toxicity and Hypersensitivity......Page 201
5.4 Testing of BloodMaterials interactions......Page 0
4.6 Tumorigenesis and Biomaterials......Page 213
4.7 implant-Associated Infection......Page 218
5.2 In Vitro Assessment of Tissue Compatibility......Page 228
5.3 In Vivo Assessment of Tissue Compatibility......Page 233
5.5 Animal Models......Page 251
6.2 Chemical and Biochemical Degradation of Polymers......Page 256
6.3 Degradative Effects of the Biological Environment on Metals and Ceramics......Page 273
6.4 Mechanical Breakdown in the Biological Environment......Page 280
6.5 Pathologic Calcification of Biomaterials......Page 285
7.2 Cardiovascular Applications......Page 296
7.3 Nonthrombogenic Treatments and Strategies......Page 310
7.4 Dental Implants......Page 321
7.5 Adhesives and Sealants......Page 332
7.6 Ophthalmologic Applications......Page 341
7.7 Orthopedic Applications......Page 348
7.8 Drug Delivery Systems......Page 359
7.9 Sutures......Page 369
7.10 Burn Dressings......Page 373
7.11 Bioelectrodes......Page 384
7.12 Biomedical Sensors and Biosensors......Page 388
8.2 Implantable Pneumatic Artificial Hearts......Page 402
8.3 Extracorporeal Artificial Organs......Page 413
PART III: PRACTICAL ASPECTS OF BIOMATERIALS......Page 426
9.2 Sterilization of Implants......Page 428
9.3 Cardiovascular Implantation......Page 433
9.4 Dental Implantation......Page 439
9.5 Ophthalmic Implantation......Page 448
9.6 Implant and Device Failure......Page 456
9.7 Correlations of Material Surface Properties with Biological Responses......Page 458
9.8 Implant Retrieval and Evaluation......Page 464
10.2 Voluntary Consensus Standards......Page 470
10.3 Product Development and Regulation......Page 474
CHAPTER 11 Perspectives and Possibilities in Biomaterials Science......Page 478
APPENDIX: Properties of Biological Fluids......Page 482
B......Page 486
C......Page 488
E......Page 489
H......Page 490
L......Page 491
O......Page 492
P......Page 493
R......Page 494
T......Page 495
W......Page 496
Z......Page 497