Biology of Menopause

Front Matter....Pages i-xviii
New Understanding of the Complexity of the Menopause and Challenges for the Future....Pages 1-8
Front Matter....Pages 9-9
Luteinizing Hormone Releasing Hormone (LHRH) Neuronal Function in Middle-Aged Female Rats....Pages 11-23
Reproductive Aging and the Human Hypothalamus....Pages 24-34
Alterations in the Pattern of Gonadotropin Secretion During the Menopausal Transition....Pages 35-44
Clinical and Scientific Significance of Perimenopausal Changes in Pituitary and Ovarian Hormone Secretion....Pages 45-53
Follicular Depletion and the Menopausal Transition....Pages 54-65
Ovarian Follicle Recruitment and Secretory Capacity in Women of Advanced Reproductive Age....Pages 66-79
New Strategies in Studying Ovarian Aging....Pages 80-88
Front Matter....Pages 89-89
Novel Mechanisms of Estrogen Action in the Developing Brain....Pages 91-102
Neuroprotective Effects of Estrogens....Pages 103-111
Cognitive Changes and Aging: Is Estrogen a Factor?....Pages 112-120
Age-Related Changes and Hormonal Regulation of Mesenchymal Stromal Stem Cells from Human Vertebral Bone Marrow....Pages 121-133
Cellular and Molecular Mechanisms of Postmenopausal Osteoporosis....Pages 134-146
Changes in Cardiovascular Risk Factors During the Peri- and Postmenopausal Years....Pages 147-158
Estrogen and the Vascular Injury Response....Pages 159-170
Effects of Mammalian and Plant Estrogens on Lipoprotein Metabolism and Coronary Heart Disease....Pages 171-180
Potential Cardioprotective Effects of Estrogen Involving Ion Channels, Endothelium, and Coronary Artery Reactivity....Pages 181-188
Role of the Membrane Estrogen Receptor in Vascular Cell Physiology....Pages 189-192
Role of Nitric Oxide in the Antiatherosclerotic Effect of 17β-Estradiol....Pages 193-210
Biological and Psychosocial Factors Affecting Sexual Functioning During the Menopausal Transition....Pages 211-222
Front Matter....Pages 223-223
Transgenic Models to Study Reproduction, Oncogenesis, and Development....Pages 225-237
Studying the Genetics of Complex But Common Human Diseases Using Mice....Pages 238-246
The Classic Steroid Hormone Receptors and ERβ, the Novel Estrogen Receptor....Pages 247-258
Estrogen Receptor Alpha versus Beta: New Estrogen Responsive Tissues and New Potentials for HRT....Pages 259-272
Putting the Menopause into Perspective: Lessons Learned from the Biology of Menopause ....Pages 273-277
Back Matter....Pages 279-289