Biology of Copper Complexes

Front Matter....Pages i-xix
Front Matter....Pages 1-1
A Physiological Basis for Pharmacological Activities of Copper Complexes: An Hypothesis....Pages 3-16
Regulation of Ceruloplasmin Synthesis by Retinoic Acid and Interleukin-1....Pages 17-30
Role of Ceruloplasmin in Copper Transport....Pages 31-41
Copper and the Regulation of Superoxide Dismutase Activity in Aortic Tissue....Pages 43-55
Front Matter....Pages 57-57
Influence of Diet and Inflammation on Serum Copper Enzymes....Pages 59-66
Copper and Connective Tissue: The Mechanism of Lysyl Oxidase....Pages 67-79
Copper — A Modulator of Peptide Release in the Brain....Pages 81-93
Copper-Dependent α-Amidation in the Synthesis of Neuroendocrine Peptide Hormones....Pages 95-107
Back Matter....Pages 108-111
Front Matter....Pages 113-113
Indices for Assessing Copper Nutriture in Animals and Humans....Pages 115-126
Dietary Simple Sugars Increase the Severity of Copper Deficiency in Experimental Animals....Pages 127-140
Hypertension Induced Alterations in Copper and Zinc Metabolism: A Link to Vascular Disease?....Pages 141-153
Manifestations of Copper Deficiency in Dairy Cattle....Pages 155-163
Observations on Biological Effects of Low Dietary Copper in Nebraska Beef Cattle....Pages 165-174
Cuprous Sebacate Treatment of Menkes’ Disease....Pages 175-184
Front Matter....Pages 185-185
Role of Neutrophils in Inflammatory Tissue Injury....Pages 187-199
Effects of Cu-Dips on Ischemia-Reperfusion Injury....Pages 201-214
Modulation of Lymphocyte Function by Copper and Thiols....Pages 215-228
Copper Regulation of Macrophage Eicosanoid and Cyclic-AMP Synthesis....Pages 229-239
Front Matter....Pages 241-241
Antiinflammatory and Antiulcer Activities of Non-Steroidal Antiinflammatory Agent Copper Complexes....Pages 243-257
Comparative Pharmacokinetics of Salicylic Acid and Copper Salicylate in Rats....Pages 259-272
Front Matter....Pages 241-241
Iamin: A Human Growth Factor with Multiple Wound-Healing Properties....Pages 273-285
Peroxide Scavenging by Cu(II) Sulfate and Cu(II) (3,5-Diisopropylsalicylate) 2 ....Pages 287-298
Front Matter....Pages 299-299
Copper Complexes Have Potent Analgesic Activity and They May Activate Opioid Receptors....Pages 301-313
Peptides and Opiates in Copper Deficiency....Pages 315-328
Mechanism of the Antimycoplasmal Activity of 2,2′-Bipyridyl Copper Complexes....Pages 329-342
Copper(I)-Nicotinic Acid Complex: An Immunopotentiator in Chickens Vaccinated Against Newcastle Disease....Pages 343-350
Back Matter....Pages 351-358
Front Matter....Pages 359-359
Anticancer Effects of Cu(II)(3,5-Diisopropylsalicylate) 2 in Mice Inoculated Intramuscularly with Ehrlich Ascites Carcinoma Cells....Pages 361-370
Effects of Cu(II)(3,5-DIPS) 2 on Solid Ehrlich Cell Tumor in Mice: A Pathological Study....Pages 371-386
Copper and Copper Enzymes in the Development and Treatment of Cancer....Pages 387-398
Catecholamide Iron Chelators: Antiproliferative Activity on Human Pathogens and Neoplasm....Pages 399-410
Front Matter....Pages 411-411
Effects of Copper Complexes on Multistage Carcinogenesis....Pages 413-424
Modulation of Benzopyrene Dependent Mutagenesis and Xanthine Oxidase Activity by Copper Complexes....Pages 425-436
Radioprotectant Effects of Cu(II)(3,5-DIPS) 2 ....Pages 437-449
Accelerated Recovery of Immunocompetent with Radioprotective Cu-DIPS....Pages 455-464
Back Matter....Pages 450-453
Front Matter....Pages 465-465
pH-Dependent Superoxide Dismutase-Mimetic Reactivity of Copper(II)Ethylenediaminetetraacetate....Pages 467-478
Nutritional Iron Bioavailability and Characterization of the Iron Binding Components of Pinto Beans....Pages 479-490
Front Matter....Pages 491-491
A Model Study for Transport of Metallo-Drugs within Lipid Bilayers....Pages 493-500
Copper, Ceruloplasmin, and Superoxide Dismutase in Tumor Bearing Mice....Pages 501-507
Structure Optimization of Amides and Amidines Derived from 1- Amino- 3-(2-Pyridyl)Isoquinoline Concerning Antimycoplasmal Activity....Pages 509-514
The Role of Cu(II) in the Addition of Ethanol to the Cyano Group and the Preparation of Novel Organic Compounds....Pages 515-522
Front Matter....Pages 491-491
Superoxide Dismutase Activity of Heart and Liver Tissue from Copper Deficient Rats....Pages 523-532
Synthesis and Biocidal Activity of Some Copper-Tridentate Schiff Bases....Pages 533-540
Determination of Human Maternal Serum Copper Levels by AAS and DCP Spectra-Span VI™ Techniques....Pages 541-549
Modulation of Immune Function as a Consequence of Copper Deprivation....Pages 551-563
Accelerated Recovery of Hematopoiesis with Radioprotective Cu-DIPS....Pages 565-572
Antiasthmatic Activity of Some Copper Complexes....Pages 573-579
The Effect of Copper on the Polyamine Oxidase Reaction....Pages 581-581
Synovial Fluid Copper, Zinc and Selenium in Relation to Inflammatory Parameters in Rheumatic Diseases....Pages 583-589
Back Matter....Pages 591-598