Biology of Cellular Transducing Signals

Front Matter....Pages i-x
Real-Time Analysis of Macromolecular Assembly During Cell Activation....Pages 1-10
Identification of Residues Essential for the Active Conformation of the ß-Adrenergic Receptor by Site-Directed Mutagenesis....Pages 11-19
Mechanisms for Diversification of Responses of Human Polymorphonuclear Leukocytes to Leukotrienes....Pages 21-27
The Role of Covalent and Non-Covalent Mechanisms in Insulin Receptor Action....Pages 29-38
EGF Triggers a Similar Signalling Cascade in Different Cell Types Overexpressing the EGF Receptor....Pages 39-47
Second Messenger Receptors in the Phosphoinositide Cycle....Pages 49-59
Mechanisms of Receptor Regulation for the Phosphoinositide Signalling System....Pages 61-72
Computer Simulation of Prostaglandin-Regulated Cyclic AMP Metabolism in Platelets: Activation and Desensitization of Adenylate Cyclase Appear to be Mediated Through Separate Prostaglandin Receptors Coupled to G S and G i ....Pages 73-82
The Family of G Proteins....Pages 83-91
Roles of G Protein Subunits in Coupling of Receptors to Ionic Channels and Other Effector Systems....Pages 93-106
Receptor-Mediated Alterations of Calcium Channel Function in the Regulation of Neurosecretion....Pages 107-114
Antibodies as Probes of G-Protein Structure and Function....Pages 115-123
Transducin: A Model of Biological Coupling Enzymes....Pages 125-132
Co-Localization by Immunofluorescence of the α Subunit(S) of G i with Cytoplasmic Structures....Pages 133-140
‘Cross-Talk’ and the Regulation of Repatocyte Adenylate Cyclase Activity: Desensitization, G 1 and Cyclic AMP Phosphodiesterase Regulation....Pages 141-152
Activation of Human Neutrophils by Granylocyte-Macrophage Colony-Stimulating Factor: Role of Guanine-Nucleotide Binding Proteins....Pages 153-162
Cytoskeletal Participation in the Signal Transduction Process: Tubulin G Protein Interactions in the Regulation of Adenylate Cyclase....Pages 163-172
Initiation and Modulation of Signal Output from the T cell Antigen Receptor....Pages 173-183
Selective Phosphorylation of a G Protein within Permeabilized and Intact Platelets Caused by Activators of Protein Kinase C....Pages 185-192
G Proteins and Toxin-Catalyzed ADP-Ribosylation....Pages 193-200
Novel Endogenous ADP-Ribosylations of Proteins in Transformed Cells: Effects of Cellular Transformation and Differentiation....Pages 201-211
Inositol 1,4,5-Trisphosphate and Inositol 1,3,4,5-Tetrakisphosphate: Two Second Messengers in a Duet of Calcium Regulation....Pages 213-225
The Role of Endogenously Stimulated Protein Kinase C in Regulating....Pages 227-233
Leukotriene D 4 Increases the Metabolism of an Inositol Tetrakisphosphate - Containing Phospholipid in U937 Cells....Pages 235-243
Immunocytochemical Localization of Protein Kinase C....Pages 245-252
A Protein Kinase C Pseudosubstrate Peptide Blocks G—Protein and Mitogenic Lectin Induced Phosphorylation of the CD3 Antigen in Human T—Lymphocytes....Pages 253-262
Growth Factor-Stimulated Tyrosine Phosphorylation of Phospholipase C....Pages 263-274
Eicosanoid Formation and Regulation of Phospholipase A 2 ....Pages 275-280
Inhibition of Phospholipase A 2 Activation in P388D 1 Macrophage-Like Cells....Pages 281-287
The Role of GTP-Binding Proteins in the Regulation of Phospholipase A 2 and C in Bovine Retinal Rod Outer Segments....Pages 289-300
Stimulus-Coupled Activation of Phospholipase D....Pages 301-311
The Orchestration of Stimulatory Signals for Secretion in Rat Basophilic Leukemia (RBL-2H3) Cells....Pages 313-322
Synchronized Ca 2+ Transients Induced by Glucagon in Fura2 Loaded Hepatocytes....Pages 323-332
Calcium Mobilization Mechanisms in Bovine Chromaffin Cells by Vasoactive Peptides: Angiotensin, Bradykinin and Endothelin....Pages 333-341
Influence of GDP(B)S on Agonist-Induced Calcium Mobilization and Platelet Function....Pages 343-352
Regulation of the production of Lipoxygenasf Products and the Role of Eicosanoids in Signal Transduction....Pages 353-357
Eicosanoid Synthesis in Resident Macrophages: Role of Protein Kinase C....Pages 359-369
Modulation of the S-K + Channel of Aplysia Sensory Neurons by Lipoxygenase Metabolites of Arachidonic Acid and cAMP....Pages 371-379
Inhibition of Leukotriene D 4 Mediated Release of Prostacyclin Using Antisense DNA....Pages 381-390
Second Messengers of Insulin Action....Pages 391-399
Control by TSH of the Production by Thyroid Cells of an Inositol Phosphateglycan, Putative Mediator of the cAMP-Independent Effects in the Gland....Pages 401-409
Back Matter....Pages 411-418