Biology of Brain Tumour: Proceedings of the Second International Symposium on Biology of Brain Tumour (London, October 24–26, 1984)

Front Matter....Pages I-XI
Front Matter....Pages 1-1
Molecular biology of cancer....Pages 3-6
Two-dimensional gel electrophoretic protein patterns in high-grade human astrocytomas....Pages 7-14
Biochemical studies of primary cultures from human astrocytomas: observations on cell growth and regulation of glutamine synthetase....Pages 15-25
Dibutyryl adenosine 3′:5′-cyclic monophosphate (db-cAMP) induced growth inhibition and morphologic changes in human medulloblastoma cell line TE671....Pages 27-34
Phenotypic modification of human glioma....Pages 35-41
Chromosomes and chromosomal progression of malignant human gliomas: theoretical and practical implications....Pages 43-49
Differential expression of neuron specific enolase and creatine phosphokinase-BB by human medulloblastoma and glioma tumors and neuroectodermal cell lines....Pages 51-59
Neovascularisation of intracranial tumours....Pages 61-66
Red blood cell polyamines in malignant glioma patients. Spermidine and spermine blood levels and tumour evolution....Pages 67-74
Front Matter....Pages 75-75
Pathological classification of tumours of the central nervous system....Pages 77-79
Modern neuropathological investigative techniques of brain tumours....Pages 81-84
Adenylate cyclase activity and cyclic AMP content in human central nervous system tumors and in cerebrospinal fluid of patients bearing brain tumors....Pages 85-90
Non-nuclear cytotoxic actions of DNA cross-linking and/or alkylating agents in glioma-derived cell lines....Pages 91-96
Intracerebral transplantation of D-54 MG human glioma line in immunosuppressed rats....Pages 97-105
In vivo characterization of a human neuroectodermal tumor cell line....Pages 107-114
Carbonic anhydrase C as a marker antigen in the diagnosis of choroid plexus papillomas and other tumours: an immunoperoxidase study.....Pages 115-120
Transplacental ENU tumors of the rat: immunohistochemical contribution to the recognition of cell types....Pages 121-129
Vascularization of human cerebral gliomas: a lectin-cytochemical and morphometric study....Pages 131-137
Immunohistochemical demonstration of HLA-DR positive cells in normal and neoplastic brain tissues. I. Preliminary Report....Pages 139-143
Primary Non-Hodgkin lymphomas of the central nervous system....Pages 145-152
Front Matter....Pages 75-75
Evaluation of a transplantable mouse brain tumour: a model for the study of human glioma....Pages 153-160
Front Matter....Pages 161-161
Neuropathology and imaging: the ways in which glioma spreads and varies in its histological aspect....Pages 163-172
Magnetic resonance imaging of central nervous system tumors....Pages 173-178
Radioimmunolocalisation of primary cerebral tumours in humans....Pages 179-187
Histological factors in the prognosis of malignant astrocytomas....Pages 189-191
Correlation of target site with histology and cell culture in CT-directed stereotactic biopsy....Pages 193-195
The vasculature of experimental brain tumours: angiogenesis, vascular pathology and permeability studies....Pages 197-202
An autoradiographic approach for studying the distribution of neurotransmitter receptor binding sites on biopsy samples of human gliomas....Pages 203-209
Drug delivery to brain tumors: physiological and pharmacokinetic aspects of chemotherapy....Pages 211-220
Experimental models of rat brain tumors by stereotactic injection of C6 glioma and HTC hepatoma cell lines....Pages 221-226
Cerebral infarction as a result of tumor emboli....Pages 227-234
Front Matter....Pages 235-235
Technical approaches to identification and stereotactic reduction of tumor burden....Pages 237-243
A surgical history of Maida Vale Hospital....Pages 245-249
Pre-operative stereo-scanning for glioma treatment planning....Pages 251-260
Stereotactic curietherapy of thalamic tumours....Pages 261-268
Intraoperative radiation therapy for glioblastoma multiforme....Pages 269-275
‘Radical’ surgical decompression of supratentorial gliomas. Do the results justify the operation?....Pages 277-286
Laser microsurgery: A review of 110 tumors of the brain and spinal cord....Pages 287-292
Carbon dioxide laser surgery for malignant glioma....Pages 293-298
Long term results of ventricular shunts performed prior to posterior fossa operation for tumor....Pages 299-307
Front Matter....Pages 235-235
Radical laser surgery in the treatment of gliomas....Pages 309-312
Preliminary observations on the use of the local thermochemotherapy in the treatment of malignant cerebral tumors....Pages 313-317
Remarks on the surgical treatment of bilateral transcallosal gliomas....Pages 319-322
Front Matter....Pages 323-323
Radiation damage to brain and cranial soft tissues: outcome and incidence before and after reduction in dose....Pages 325-334
Radiotherapy with a three-fraction per day regimen in a split course of irradiation for malignant high grade astrocytomas....Pages 335-341
Non-invasive thermochemotherapy for advanced brain tumors....Pages 343-347
 252 CF Neutron brachytherapy for malignant glioma at the University of Kentucky and a malignant glioma therapeutic staging system....Pages 349-354
Permanent radioactive iodine seed implants following radical resection in recurrent human malignant high grade astrocytomas....Pages 357-363
Technique and preliminary results of interstitial irradiation for recurrent glial tumors....Pages 367-372
Results of definitive irradiation for optic gliomas....Pages 375-379
Front Matter....Pages 381-381
Current approaches to chemotherapy....Pages 383-392
Cisplatin, arabinofuranosyl cytosine, and caffeine before radiation for glioblastomas....Pages 393-398
Multimodality therapy of supratentorial high-grade gliomas....Pages 399-403
The use of experimental models of human medulloblastoma in the design of rational therapy....Pages 405-409
Phase II study of novantrone (mitroxantrone hydrochloride) in adults with grade III-IV astrocytomas....Pages 411-413
An experimental study of xenografted human gliomas....Pages 415-421
Human central nervous system pharmacology of tiazofurin....Pages 423-427
Primary therapy of medulloblastoma with surgery, radiation and methotrexate and BCNU — A pilot study....Pages 429-432
Cyclophosphamide, Adriamycin, vincristine, and dexamethasone in the treatment of bulky central nervous system lymphoma....Pages 433-436
Effect of Intracarotid administration of BCNU in rats....Pages 437-443
Front Matter....Pages 381-381
Intravenous and subarachnoid Adriamycin in experimental meningeal carcinomatosis: tissue concentration and therapeutic efficacy....Pages 445-452
Adriamycin in the treatment of malignant meningiomas....Pages 453-455
Heterogeneity in response of short-term glioma cell cultures to cytotoxic drugs: correlation of in vitro chemosensitivity and relapse free interval....Pages 457-464
High dose polichemotherapy with autologous bone marrow transplantation in recurrent medulloblastoma. A pilote study....Pages 465-468
Phase I study of intraarterial mitomycin-c for recurrent intracerebral tumors....Pages 469-473
 In vitro phase II trial with the human tumor stem cell assay as a new brain tumor model for drug screening: preliminary results....Pages 475-479
Front Matter....Pages 481-481
Immunotherapy of patients with brain tumors — current prospective....Pages 483-486
Effect of interferons and an interferon inducer on malignant brain tumors....Pages 487-494
Antigenic heterogeneity of human glioma tissue and cell lines (HGL) defined by monoclonal antibodies (MAs)....Pages 495-499
T-cell mediated cytotoxicity in human glioma....Pages 501-507
Modulation of HLA-DR expression and growth inhibition on glioma cells: heterogeneous responses to interferon-γ....Pages 509-515