Biology and Physiology of the Blood-Brain Barrier: Transport, Cellular Interactions, and Brain Pathologies

Front Matter....Pages i-xvi
Development of Blood-Brain Barrier Endothelial Cells....Pages 1-7
Prospects for Neuroprotective Gene Therapy for Neurodegenerative Diseases....Pages 9-10
Blood-Brain Barrier Taurine Transport and Brain Volume Regulation....Pages 11-16
Volume Regulation of the in Vitro Blood-Brain Barrier by Osmoreactive Amino Acids during Stress....Pages 17-19
A Reduction in the Transfer of Amino Acids Across the Blood-Brain Barrier Might Not be the Sole Mechanism by Which Vasopressin Affects Amino Acid Levels within the Brain....Pages 21-26
Differential Amino Acid Uptake into Cerebral Parenchyma and Capillary Cells during Development....Pages 27-33
Transport of 3 H L-Alanine Across the Blood-Brain Barrier of in Situ Perfused Guinea Pig Brain....Pages 35-39
Distribution of Small Neutral Amino Acids after Penetrating the Luminal Side of the Guinea Pig Blood-Brain Barrier....Pages 41-45
The Blood-Brain Barrier, Potassium, and Brain Growth....Pages 47-50
Receptor-Mediated Transcytosis of Transferrin through Blood-Brain Barrier Endothelial Cells....Pages 51-54
Intracerebral Expression of Transferrin Receptors in Iron-Deficient Rats....Pages 55-61
Vascular Permeability to Hemorphins in the Central Nervous System....Pages 63-68
The Effect of Glycosylation on the Uptake of an Enkephalin Analogue into the Central Nervous System....Pages 69-77
Blood-Retina Barrier Properties of the Pecten Oculi of the Chicken....Pages 79-81
The Microarchitecture of Cerebral Vessels....Pages 83-91
Development of Blood-Brain Barrier Tight Junctions....Pages 93-95
Membrane Fractionation of Brain Capillary Endothelial Cells and Analysis of Lipid Polarity....Pages 97-101
“Brain-Tissue-Specific” Versus “Serum-Specific” Posttranslational Modification of Human Cerebrospinal Fluid Polypeptides with N-Linked Carbohydrates....Pages 103-107
Blood-Brain Barrier Properties in Vitro as Related to the Neurotransmitter Serotonin....Pages 109-115
A 5-HT 2 Receptor-Mediated Breakdown of the Blood-Brain Barrier Permeability and Brain Pathology in Heat Stress....Pages 117-124
Correlation between the in Vitro and in Vivo Blood-Brain Barrier Permeabilities of H 2 Receptor Antagonists....Pages 125-136
The Blood-Brain Barrier and Brain Morphology Following Insertion of a Dialysis Probe....Pages 137-141
Blood-Brain Barrier in Vitro ....Pages 143-146
New Techniques to Study Transepithelial and Transendothelial Resistances of Cultured Cells....Pages 147-152
The Blood-CSF Barrier in Vitro ....Pages 153-158
Penetration of 3 H Tiazofurin from Blood into Guinea Pig Brain....Pages 159-164
The Permeability of Boronophenylalanine....Pages 165-167
Differences between the Calculated Fraction Available for BBB Transport and the in Vitro Measured Free Fraction Could be Explained by Capillary Heterogeneity....Pages 169-170
The Strongest Expression of P-Glycoprotein is in the Blood-Brain Barrier....Pages 171-174
Functional Expression of Multidrug Resistance P-Glycoprotein in Cellular Models of Physiological Barriers....Pages 175-183
A Method to Assess Functional Activity of P-Glycoprotein in Vitro Based on the Energy Requirements of the Transporter....Pages 185-189
P-Glycoprotein Activity in an in Vitro Blood-Brain Barrier Model....Pages 191-196
Brain Penetration of SDZ PSC 833 in Rats....Pages 197-204
Peptide-Like Drugs May be Excluded from the Brain by P-Glycoprotein at the Blood-Brain Barrier....Pages 205-207
Significance of the Second Messenger Molecules in the Regulation of Cerebral Endothelial Cell Functions....Pages 209-211
The Role of Protein Kinase C and Marcks Protein Phosphorylation in Rat Cerebromicrovascular Endothelial Cell Proliferation Induced by Astrocyte-Derived Factors....Pages 213-220
Calcium and Protein Kinase C Signaling in Response to Vasoactive Peptides in Human Cerebromicrovascular Endothelial Cells....Pages 221-227
The Effect of Conditioned Medium of Porcine Astrocytes and Different Cell Lines on the Activity of the Marker Enzymes Alp and γ-GT in Endothelial Cells of Porcine Brain Microvessels....Pages 229-233
Hypoxia Augments Na + -K + -Cl - Cotransport Activity in Cultured Brain Capillary Endothelial Cells of the Rat....Pages 235-240
Effects of Histamine on the Acid Phosphatase Activity of Cultured Cerebral Endothelial Cells....Pages 241-243
A Comparison of Lymphocyte Migration Across the Anterior and Posterior Blood-Retinal Barrier in Vitro ....Pages 245-251
Disruption of Membranous Monolayers of Cultured Pig and Rat Brain Endothelial Cells Induced by Activated Human Polymorphonuclear Leukocytes....Pages 253-261
Response of Brain Endothelial Cells and Bone-Marrow Macrophages to Leukocyte-Derived Effectors....Pages 263-269
Expression of Macrophage Chemotactic Protein-1 in Rat Glial Cells....Pages 271-277
T-Cell Line Interactions with Brain Endothelial Monolayers....Pages 279-284
Development and Characterization of SV40 Large T Immortalized Endothelial Cells of the Rat Blood-Brain and Blood-Retinal Barriers....Pages 285-292
Glyceraldehyde-3-Phosphate Dehydrogenase Binds to the Cytoplasmic Domain of Intercellular Adhesion Molecule-1....Pages 293-297
Hypertensive Versus Normotensive Monocyte Adhesion to Cultured Cerebral Microvascular Endothelial Cells....Pages 299-302
The Effect of Inflammatory Agents upon the Blood-Retinal Barrier....Pages 303-309
Identification of the Penumbra in an Ischemic Rat Model by MRI after Injection of a Superparamagnetic Contrast Agent....Pages 311-316
Hypoxia and Reoxygenation of a Cellular Barrier Consisting of Brain Capillary Endothelial Cells and Astrocytes....Pages 317-322
Effects of Hypoxia on an in Vitro Blood-Brain Barrier....Pages 323-325
Extracellular Matrix Proteins in Cerebral Vessels in Chronic Hypertension....Pages 327-331
The Effect of Nicotine Pretreatment on the Blood-Brain Barrier Permeability in Nicotine-Induced Seizures....Pages 333-338
Asymmetrical Changes in Blood-Brain Barrier Permeability during Pentylenetetrazol-Induced Seizures in Rats....Pages 339-341
Influence of Intracarotid Hyperthermic Saline Infusion on the Blood-Brain Barrier Permeability in Anesthetized Rats....Pages 343-346
Recovery from Acute Experimental Autoimmune Encephalomyelitis (EAE) Characterized by Endothelial Cell Unresponsiveness to Cytokines and Pericyte Activation....Pages 347-351
Time-Course of Demyelination and Blood-Brain Barrier Disruption in the Semliki Forest Virus Model of Multiple Sclerosis in the Mouse....Pages 353-359
Blood-Brain Barrier Permeability Changes during Semliki Forest Virus-Induced Encephalomyelitis in the Balb/c Mouse....Pages 361-364
HIV-1 Encephalitis is a Consequence of Viral Infection and Neuroimmune Activation....Pages 365-367
Evaluation of Blood-Brain Barrier Rupture in a Rat Glioma Model by Using a Contrast Agent for Magnetic Resonance Imaging....Pages 369-373
Dynamics of Permeability of Blood-Tumor Barrier in Patients with Brain Gliomas....Pages 375-377
Effects of Induction of Inducible Nitric Oxide Synthase on Brain Cortical Blood Flow and Blood-Brain Barrier....Pages 379-386
Back Matter....Pages 387-387