Biological Role of Indolealkylamine Derivates - Proceedings of a Symposium held at The College of Physicians and Surgeons, Columbia University, New York, New York, 10–12 May 1967

Content: 
Advisory Board
Page ii

Edited by
Page iii

Copyright page
Page iv

Contributors to this Volume
Pages v-ix

Preface
Page xi
Parkhurst A. Shore, Silvio Garattini

Introductory Remarks
Page 3
S. Udenfriend

Tryptophan-5-Hydroxylase in Mammalian Brain Original Research Article
Pages 5-17
A. Ichiyama, S. Nakamura, Y. Nishizuka, O. Hayaishi

Discussion of Tryptophan-5-Hydroxylase in Mammalian Brain Original Research Article
Pages 18-19
Harry Green

Tryptophan Hydroxylation in Mammalian Systems Original Research Article
Pages 21-36
Walter Lovenberg, Eric Jequier, Albert Sjoerdsma

Discussion of Tryptophan Hydroxylation in Mammalian Systems Original Research Article
Pages 37-42
D.G. Grahame-Smith

The Purification and Properties of Beef Liver Mitochondrial Monoamine Oxidase Original Research Article
Pages 43-59
Kerry T. Yasunobu, Ikuo Igaue, Benedict Gomes

Properties of the Monoamine Oxidase of Rat Liver Mitochondria Original Research Article
Pages 61-69
T.L. Sourkes

The Fluorometric Determination of Indolealkylamines in Brain and Pineal Gland Original Research Article
Pages 71-77
R.P. Maickel, F.P. Miller

Indoleacetaldehydes—Intermediates in Indolealkylamine Metabolism Original Research Article
Pages 79-89
D. Keglević, S. Kveder, S. Iskrić

Serotonin Metabolism in Pineal Homogenates Original Research Article
Pages 91-96
Aaron Feldstein, Owen Williamson

In Vivo Measurement of Brain Serotonin Turnover Original Research Article
Pages 97-109
N.H. Neff, T.N. Tozer

Discussion of in Vivo Measurement of Brain Serotonin Turnover Original Research Article
Pages 110-112
G.W. Ashcroft, A.T.B. Moir, D. Eccleston

Uptake and Binding of Serotonin by the Platelet and Its Granules Original Research Article
Pages 113-122
E.W. Maynert, Lawrence Isaac

The Uptake of Serotonin by Central Neurons Normally Containing Catecholamines Original Research Article
Page 123
Walter Lichtensteiger, Heinrich Langemann

Electron Microscopic Study of the Storage Site of 5-Hydroxytryptamine in Blood Platelets Original Research Article
Pages 125-128
J.P. Tranzer, M. Da Prada, A. Pletscher

Reporter\'s Remarks
Pages 129-131
Herbert Weissbach

Introductory Remarks Original Research Article
Pages 135-139
E. De Robertis

The Formation, Metabolism, and Physiologic Effects of Melatonin Original Research Article
Pages 141-151
Richard J. Wurtman, Julius Axelrod

Discussion of the Formation, Metabolism, and Physiologic Effects of Melatonin Original Research Article
Pages 152-155
Benjamin Weiss

Photic and Neural Control of Indoleamine Metabolism in the Rat Pineal Gland Original Research Article
Pages 157-166
Julius Axelrod, Richard J. Wurtman

On the Significance of the 5-Hydroxytryptamine Stores in Pineal Gland Original Research Article
Pages 167-169
Christer Owman

Distribution of Serotonin in the Nervous System of Various Animal Species Original Research Article
Pages 171-188
John H. Welsh

Discussion of the Distribution of Serotonin in the Nervous System of Various Animal Species Original Research Article
Pages 189-190
M.A. Beaven

Control of Brain Serotonin and Norepinephrine by Specific Neural Systems Original Research Article
Pages 191-206
Alfred Heller, Robert Y. Moore

A Discussion of Control of Brain Serotonin and Norepinephrine by Specific Neural Systems Original Research Article
Pages 207-209
Floyd E. Bloom

5-Hydroxytryptamine and Related Amines in Endocrine Cell Systems Original Research Article
Pages 211-231
Bengt Falck, Christer Owman

Discussion of 5-Hydroxytryptamine and Related Amines in Endocrine Cell Systems Original Research Article
Pages 232-233
A. Dahlström

Localization of Indolealkylamines in CNS Original Research Article
Pages 235-251
Kjell Fuxe, Tomas Hökfelt, Urban Ungerstedt

Discussion of the Localization of Indolealkylamines in CNS Original Research Article
Pages 252-255
Robert E. Barrett

Neuronal Compartmentation of 5-Hydroxytryptamine Stores Original Research Article
Pages 257-270
Amanda Pellegrino de Iraldi, Luis M. Zieher, Guillermo Jaim Etcheverry

Discussion of the Neuronal Compartmentation of 5-Hydroxytryptamine Stores Original Research Article
Pages 271-274
I.A. Michaelson

Reporter\'s Remarks Original Research Article
Pages 275-277
R.S. Stacey

Introductory Remarks Original Research Article
Pages 281-282
Irvine H. Page

Comparative Physiology of Serotonin and Melatonin Original Research Article
Pages 283-297
W.B. Quay

Discussion of the Comparative Physiology of Serotonin and Melatonin Original Research Article
Pages 298-300
Floyd E. Bloom

Development of Enzyme Activities and a Circadian Rhythm in Pineal Gland Serotonin: Evidence for a Nonretinal Pathway of Light to the Pineal Gland of Newborn Rats Original Research Article
Pages 301-305
Solomon H. Snyder

Serotonin, Norepinephrine, and Fever Original Research Article
Pages 307-317
N.J. Giarman, C. Tanaka, J. Mooney, E. Atkins

Discussion of Serotonin, Norepinephrine, and Fever Original Research Article
Pages 318-321
Robert D. Myers

Serotonin Participation in the Vagal Inhibitory Pathway to the Stomach Original Research Article
Pages 323-333
E. Bülbring, M.D. Gershon

Serotonin and Dopamine in the Extrapyramidal System Original Research Article
Pages 335-346
Theodore L. Sourkes, L.J. Poirier

Discussion of Serotonin and Dopamine in the Extrapyramidal System Original Research Article
Pages 347-349
Nils-Erik Andén

Stimulation-Induced Release of Serotonin Original Research Article
Pages 351-364
Thomas N. Chase, George R. Breese, David O. Carpenter, Saul M. Schanberg, Irwin J. Kopin

Discussion of Stimulation-Induced Release of Serotonin Original Research Article
Pages 365-368
P. Ascher, J. Glowinski, L. Tauc, J. Taxi

Evidence for an Excitatory Transmitter Role of Serotonin in Molluscan Central Synapses Original Research Article
Pages 369-392
H.M. Gerschenfeld, E. Stefani

Discussion of Evidence for an Excitatory Transmitter Role of Serotonin in Molluscan Central Synapses Original Research Article
Pages 393-394
M. Mirolli

Serotonin Effects on Central Neurons Original Research Article
Pages 395-413
F.F. Weight, G.C. Salmoiraghi

Discussion of Serotonin Effects on Central Neurons Original Research Article
Pages 414-418
C. Stefanis

Reporter\'s Remarks Original Research Article
Pages 419-421
J.R. Vane

Author Index
Pages 423-436

Subject Index
Pages 437-440

Advisory Board
Page ii

Edited by
Page iii

Copyright page
Page iv

Preface
Page v
Parkhurst A. Shore, Silvio Garattini

Contributors To This Volume
Pages vii-ix

Introductory Remarks Original Research Article
Page 3
P.A. Shore

Possible Mechanism of Action of Serotonin on Molluscan Muscle Original Research Article
Pages 5-15
Betty M. Twarog

Discussion of the Possible Mechanism of Action of Serotonin on Molluscan Muscle Original Research Article
Pages 16-17
Maurice M. Rapport

Cerebral Tryptamine Receptors: Functional Considerations Original Research Article
Pages 19-25
Marthe Vogt

Discussion of Cerebral Tryptamine Receptors: Functional Considerations Original Research Article
Pages 26-28
Watson D. Reid

The Pharmacology of para-Chlorophenylalanine, a Selective Depletor of Serotonin Stores Original Research Article
Pages 29-47
B. Kenneth Koe, Albert Weissman

Central Serotonin Neurons and Thermoregulation Original Research Article
Pages 49-54
H. Corrodi, K. Fuxe, T. Hökfelt

Effects of Benzoquinolizines and Ring-Substituted Aralkylamines on Serotonin Metabolism Original Research Article
Pages 55-69
A. Pletscher, M. Da Prada, W.P. Burkard, J.P. Tranzer

Discussion of the Effects of Benzoquinolizines and Ring-Substituted Aralkylamines on Serotonin Metabolism Original Research Article
Pages 70-71
F. Sulser

Relation of 5-Hydroxytryptamine and Catecholamine Depletion to the Central Depressive Action of a Reserpine Derivative with Differential Action on Brain Monoamines Original Research Article
Pages 73-74
Antonín Dlabač

Factors Modulating Brain Serotonin Turnover Original Research Article
Pages 75-92
P.M. Diaz, S.H. Ngai, E. Costa

Discussion of Factors Modulating Brain Serotonin Turnover Original Research Article
Pages 93-95
B. Werdinius

Serotonin in Brain: Functional Considerations Original Research Article
Pages 97-113
Bernard B. Brodie, Watson D. Reid

Reporter\'s Remarks Original Research Article
Pages 115-119
A. Carlsson

Introductory Remarks Original Research Article
Pages 123-125
Albert Sjoerdsma

The Role of 5-Hydroxyindoles in the Carcinoid Syndrome Original Research Article
Pages 127-142
M. Sandler

Discussion of the Role of 5-Hydroxyindoles in the Carcinoid Syndrome Original Research Article
Pages 143-145
Virginia E. Davis

Discussion of the Role of 5-Hydroxyindoles in the Carcinoid Syndrome Original Research Article
Pages 146-149
Richard B. Davis

5-Hydroxyindoles and the Thyroid Original Research Article
Pages 151-155
E.D. Williams

Discussion of 5-Hydroxyindoles and the Thyroid Original Research Article
Pages 156-157
A.G.E. Pearse

5-Hydroxyindoles in Phenylketonuric and Nonphenylketonuric Mental Defectives Original Research Article
Pages 159-165
C.M.B. Pare

Discussion of 5-Hydroxyindoles in Phenylketonuric and Nonphenylketonuric Mental Defectives Original Research Article
Pages 166-168
B.E. Roos

Tryptophan Hydroxylation in Phenylketonuria Original Research Article
Pages 169-170
Eric Jéquier

Indole Metabolism in Hartnup Disease Original Research Article
Pages 171-175
John B. Jepson

Discussion of Indole Metabolism in Hartnup Disease Original Research Article
Pages 176-177
M.A. Crawford

5-Hydroxyindole Metabolism in Pregnancy Original Research Article
Pages 179-186
Jennifer Southgate, M. Sandler

Effect of 5-Hydroxytryptamine on Maintenance of Pregnancy, Congenital Abnormalities, and the Development of Toxemia Original Research Article
Pages 187-189
J.M. Robson, F.M. Sullivan

5-Hydroxyindoles and Migraine Original Research Article
Pages 191-200
G. Curzon

Discussion of 5-Hydroxyindoles and Migraine Original Research Article
Pages 201-202
Melvin D. Yahr

Plasma Serotonin Levels in Migraine Original Research Article
Page 203
Michael Anthony

Reporter\'s Remarks Original Research Article
Pages 205-206
H. Blaschko

Introductory Remarks Original Research Article
Pages 209-211
W.L.M. Perry

Fate and Metabolism of Some Hallucinogenic Indolealkylamines Original Research Article
Pages 213-229
Ulf Ahlborg, Bo Holmstedt, Jan-Erik Lindgren

Discussion of the Fate and Metabolism of Some Hallucinogenic Indolealkylamines Original Research Article
Pages 230-231
S. Szara

Pharmacologic Studies on the Structure-Activity Relationship of Hydroxyindole Alkylamines Original Research Article
Pages 233-246
A. Cerletti, M. Taeschler, H. Weidmann

Discussion of the Pharmacologic Studies on the Structure-Activity Relationship of Indolealkylamines Original Research Article
Pages 247-248
William M. McIsaac, Robert T. Harris

Behavioral Changes and 5-Hydroxytryptamine Turnover in Animals Original Research Article
Pages 249-260
L. Valzelli, S. Garattini

Discussion of Behavioral Changes and 5-Hydroxytryptamine Turnover in Animals Original Research Article
Pages 261-263
M.H. Aprison

Insomnia and Decrease of Cerebral 5-Hydroxytryptamine after Destruction of the Raphe System in the Cat Original Research Article
Pages 265-279
M. Jouvet

Discussion of Insomnia and Decrease of Cerebral 5-Hydroxytryptamine after Destruction of the Raphe System in the Cat Original Research Article
Pages 280-282
Werner P. Koella