Biological Response Mediators and Modulators. John Jacob Abel Symposia on Drug Development

Content: 
JOHN JACOB ABEL SYMPOSIAON DRUG DEVELOPMENT, Page ii
Front Matter, Page iii
Copyright, Page iv
Dedication, Page v
Contributors, Pages xi-xiii
Preface, Pages xv-xvii
Acknowledgments, Page xix
RECEPTOR-MEDIATED ENDOCYTOSIS AS EXEMPLIFIED BY THE LOW DENSITY LIPOPROTEIN RECEPTOR, Pages 1-6, Michael S. Brown, Joseph L. Goldstein
THE RECEPTOR FOR EGF FUNCTIONS AS A TYROSINE-SPECIFIC PROTEIN KINASE, Pages 7-12, Stanley Cohen
REGULATION OF INSULIN RECEPTOR METABOLISM: MECHANISM OF INSULIN-INDUCED RECEPTOR DOWN-REGULATION, Pages 13-39, M. Daniel Lane, Gabriele V. Ronnett, Victoria P. Knutson
METABOLISM OF ARACHIDONIC ACID BY THE CYCLOOXYGENASE PATHWAY IN MAST CELLS AND BY THE 15-LIPOXYGENASE PATHWAY IN HUMAN EOSINOPHILS, Pages 41-47, John A. Oates
PHYSIOLOGIC AND PATHOBIOLOGIC EFFECTS OF LEUKOTRIENES C4, D4, AND E4, Pages 49-57, Robert A. Lewis
BIOLOGICAL ACTIVITIES OF LEUKOTRIENE B4 AND OTHER HYDROXYEICOSATETRAENOIC ACIDS (HETEs), Pages 59-66, A.W. Ford-Hutchinson
ACETYL GLYCERYL ETHER PHOSPHORYLCHOLINE (AGEPC) A MODEL ANAPHYLACTOMIMETIC MEDIATOR, Pages 67-82, R. Neal Pinckard, Linda M. McManus, Marilyn Halonen, David M. Humphrey, Donald J. Hanahan
THE ROLE OF LIPOXYGENASE PRODUCTS OF ARACHIDONIC ACID IN INFLAMMATORY EVENTS MEDIATED BY HUMAN BASOPHILS AND MAST CELLS, Pages 83-97, Stephen P. Peters, Robert P. Schleimer, Ann Kagey-Sobotka, Edward S. Schulman, Donald W. MacGlashan Jr., G. Kenneth Adams III, Lawrence M. Lichtenstein
THE CHEMISTRY AND BIOLOGY OF C3a, C4a, AND C5a AND THEIR EFFECTS ON CELLS, Pages 99-116, Tony E. Hugli
ON THE SIZE HETEROGENEITY AND MOLECULAR COMPOSITION OF THE TRANS-MEMBRANE CHANNELS PRODUCED BY COMPLEMENT, Pages 117-139, Louise E. Ramm, David W. Michaels, Michael B. Whitlow, Manfred M. Mayer
MEMBRANE DAMAGE BY COMPLEMENT COMPONENTS C5b-C9: BIOCHEMICAL AND ULTRASTRUCTURAL STUDIES, Pages 141-162, Sucharit Bhakdi, Jørgen Tranum-Jensen
CYTOKINE-CELL INTERACTIONS THAT MODULATE INFLAMMATORY REACTIONS, Pages 163-176, Joost J. Oppenheim
INTERLEUKIN-2 AND THE REGULATION OF CYTOTOXIC CELLS, Pages 177-183, Christopher S. Henney, Donald E. Kern, Steven Gillis
PHARMACOLOGICAL MODULATIONS OF IgE-BINDING FACTOR, Pages 185-197, Kimishige Ishizaka
MECHANISMS OF ANTIVIRAL ACTION OF INTERFERONS, Pages 199-209, Robert M. Friedman
PHARMACOLOGICAL MANIPULATION OF THE CHEMOTACTIC FACTOR RECEPTOR ON LEUKOCYTES, Pages 211-219, Ralph Snyderman, Itzhak Yuli, Catherine Koo
SECRETORY PRODUCTS IN CYTOTOXICITY, Pages 221-239, Carl F. Nathan
ANTIBODY-MEDIATED TUMOR SUPPRESSION: POSSIBLE ROLE OF LYSOPHOSPHATIDYLCHOLINE AND INTERLEUKIN 1, Pages 241-250, Hyun S. Shin
Index, Pages 251-254