Biological Monitoring of Exposure and the Response at the Subcellular Level to Toxic Substances: Proceedings of the European Society of Toxicology Meeting held in Munich, September 4–7, 1988

Front Matter....Pages I-XIII
Front Matter....Pages 1-1
m-Dinitrobenzene: Studies on its Toxicity to the Testicular Sertoli Cell....Pages 3-17
Front Matter....Pages 19-19
Metals — Epidemiological and Experimental Evidence for Carcinogenicity....Pages 21-27
Mechanistic Aspects of Chromium Carcinogenicity....Pages 28-39
Mechanistic Aspects of Nickel Carcinogenicity....Pages 40-47
Differing Effects of Chromium(III) and Chromium(VI) on Nucleotides and DNA....Pages 48-51
Front Matter....Pages 53-53
Nucleic Acid-Carcinogen Adducts in Human Dosimetry....Pages 55-65
Molecular Dosimetry of Genotoxic Damage....Pages 66-82
Protein-Carcinogen Adducts in Human Dosimetry....Pages 83-90
Individual Exposure Monitoring from Plasma or Urinary Metabolite Determination....Pages 91-100
 32 P-Postlabelling of DNA Adducts in White Blood Cells of Foundry Workers....Pages 101-103
A Sensitive Method for the Determination of Urinary Mercapturic Acids for use in Biological Monitoring....Pages 104-107
Biological Monitoring of Exposure to Ethylene Glycol Ethers....Pages 108-111
Liver Damage after Coal-tar Treatment does not Prevent Induction of Glutathione S-Transferases in Rat Liver....Pages 112-116
The Significance of Urinary Thioethers as Indicators of Exposure to Alkylating Agents....Pages 117-119
Ethylenethiourea as an Indicator of Exposure to Ethylenebisdithiocarbamate Fungicides....Pages 120-123
Application of Flame Atom Trapping and Column Preconcentration Techniques to the Measurement of Cadmium in Urine....Pages 124-127
Different Affinity of Erythrocyte Glutathione-S-Transferase to Methyl Chloride in Humans....Pages 128-132
The Combinations of Inducers of the Coumarin Hydroxylase-Locus Help Investigate their Mode of Action....Pages 133-137
Front Matter....Pages 139-139
Gene Structure and Regulation of Cytochrome P-450....Pages 141-144
Evidence for Several Hepatic Proteins Related to Microsomal Epoxide Hydrolase....Pages 145-152
Front Matter....Pages 153-153
Expression of P-450 Enzyme Activities in Heterologous Cells by Transfection....Pages 155-163
Introduction of Cytochrome P-450 Genes into V79 Chinese Hamster Cells to Generate New Mutagenicity Test Systems....Pages 164-168
Front Matter....Pages 169-169
Thymus Atrophy and Immunosuppression Induced by Organotin Compounds....Pages 171-174
An Immunohistochemical Study of Dibutyltin-Induced Thymus Atrophy....Pages 175-178
Inhibition of Phytohemagglutinine-Induced T Lymphocyte Proliferation by 6-(octadecyldithio)purine, a Novel Liposomal Prodrug of 6-mercaptopurine....Pages 179-182
Effects of Ammonia Caramel and Tetrahydroxybutylimidazole on the Immune System of Rats....Pages 183-187
The Popliteal Lymphnode Assay (PLNA) in Rodents: A Simple Functional Test for Detecting Sensitizing Effects of Xenobiotics....Pages 188-190
Comparative Study on the Toxicity of Acetaminophen and Mercuric Chloride in Normal and Athymic Mice and Rats....Pages 191-196
Significance of Serum Ferritin Concentrations in Lung Cancer and it’s Relation with Cellular Immunity....Pages 197-199
Front Matter....Pages 201-201
Metabolic Activation of Diethylstilbestrol and 7,8-Benzoflavone in Hamster Hepatocytes....Pages 203-205
Prostaglandin-H-Synthase Catalyzed Formation of Reactive Intermediates from Stilbene and Steroid Estrogens: Covalent Binding to Proteins....Pages 206-210
Hypomethylation of c-myc Proto-oncogene of N-Nitrosomorpholine — Induced Rat Liver Nodules and of H4IIE Cells....Pages 211-213
Determination of 7-(2-Oxoethyl)guanine and N 2 ,3-Ethenoguanine in DNA Hydrolysates by HPLC....Pages 214-218
Detection of Acrolein Congener-DNA Adducts Isolated from Cellular Systems....Pages 219-223
The DNA-Adducts of the Food Mutagen and Carcinogen IQ (2-amino-3-methylimidazo [4,5-f]quinoline)....Pages 224-226
The Role of Extrahepatic Organs in the First Pass Metabolism of N-Nitrosodibutylamine....Pages 227-229
Modulation of 17α-Ethinylestradiol and 7,8-Benzoflavone Metabolism in Hamster Liver Microsomes is Possibly Related to Hepatotumorigenesis....Pages 230-232
Incidence of Preneoplastic Foci in Rat Liver Dependent on Different Promoting Schemes....Pages 233-236
Metabolism and Endogenous Production of Ethylene in Rat and Man....Pages 237-239
Pharmacokinetics of Propylene and its Reactive Metabolite Propylene Oxide in Sprague-Dawley Rats....Pages 240-242
Front Matter....Pages 201-201
Detection of DNA-Protein Crosslinks in the Kidney of Male B6C3F1 Mice after Exposure to Methyl Chloride....Pages 243-245
Species Differences in DNA Damage by Butadiene: Role of Diepoxybutane....Pages 246-249
Determination of 7-(2-hydroxyethyl)Guanine with Gas Chromatography/Mass Spectrometry as a Parameter for Genotoxicity of Ethylene Oxide....Pages 250-253
The Relationships between Alkylation of Haemoglobin and DNA in Fischer 344 Rats Exposed to [ 14 C]Ethylene Oxide....Pages 254-257
Influence of Cytochrome P-450 Inhibitors on the Inhalative Uptake of Methyl Chloride and Methylene Chloride in Male B6C3F1 Mice....Pages 258-261
Cisplatin Binding to Plasma Proteins and Hemoglobin in Cancer Patients....Pages 262-264
A Simple Statistical Procedure for Testing Tumour Rates in Animal Carcinogenicity Experiments....Pages 265-268
Front Matter....Pages 269-269
Characterization of Microsomal and Cytoplasmic Metyrapone Reducing Enzymes from Mouse Liver....Pages 271-274
Prevention of Liver Cell Damage Following Lipid Peroxidation by Depression of Lysophosphatide Formation....Pages 275-281
Spontaneous and Xenobiotic-Induced In Vivo -Lipid Peroxidation in Iron-Overloaded Rats....Pages 282-286
Thioether Formation — Activation or Detoxication?....Pages 287-290
N-Demethylation Reactions in Intact Erythrocytes and Erythrocyte Supernatant....Pages 291-293
Effect of Toxogonin on the Rat Liver Drug Metabolizing Enzyme Systems....Pages 294-296
Selective Induction of the Coumarin Hydroxylase by N-Containing Heteroaromatic Compounds....Pages 297-301
Dichloromethane Metabolism to Carbon Monoxide can be Induced by Isoniazid, Acetone and Fasting....Pages 302-303
Study of Nafenopin, a Hypolipidemic Drug on Liver Metabolism....Pages 304-308
Inhibitory Effect of Cholephilic Organic Acids on Hepatobiliary Transport and Mitochondrial Respiration....Pages 309-311
Biochemical Investigation of Atractylis Gummifera L. Hepatotoxicyty in the Rat....Pages 312-315
Protective Effect of Zinc Against Hepatotoxic Agents in the Rat Liver Slice System: Role of Metallothionein....Pages 316-318
Differences in Liver Sensitivity to Methyl Carbamate between Wistar and Fischer 344 Rats....Pages 319-321
Front Matter....Pages 269-269
Study of Glutathione and Glutathione Related Enzymes in Acetaminophen-Poisoned Mice. Prevention by Anethole Trithione Pretreatment....Pages 322-325
Depletion of Hepatic Glutathione in Rats Impairs Phagocytosis In Vivo ....Pages 326-329
Pharmacokinetics and Hepatotoxicity of 2-Nitropropane in Rats....Pages 330-332
Biliary Excretion of Mutagenic Forms of Nitroimidazoles in Rats....Pages 333-339
Effect of Arsenicals on Biliary Excretion of Endogenous Non-Protein Thiols, Mercurials and Sulfobromophthalein....Pages 340-342
Influence of Glucocorticoids on the Postnatal Development of Cytochrome P-450 in Rat Liver....Pages 343-346
Front Matter....Pages 347-347
Sulfhydryl-Induced Restoration of Myocardial Contractility after Alteration by Mercury....Pages 349-352
Renal Ultrastructural Alterations and Cardiovascular Functional Changes in Rats Exposed to Mercuric Chloride....Pages 353-356
Different Effects of Intraperitoneally and Orally Administered Palladium Chloride on the Hepatic Monooxygenase System of Male Mice....Pages 357-362
Effect of Arsenic on Cellular Metabolism after Single or Repeated Injection in Guinea Pigs....Pages 363-365
Influence of Strontium Chloride on Blood Platelet Function....Pages 366-369
Influence of Triethylenetetramine and D-Penicillamine on Zinc Metabolism in Mice....Pages 370-372
Front Matter....Pages 373-373
Behavioural and Neurochemical Changes Produced by Lefetamine in Two Inbred Strains of Mice....Pages 375-377
Effects of Carbamates upon Various Behavioural Parameters in Mice....Pages 378-380
The Effect of Gentamicin on the Cockroach Nerve Cord....Pages 381-385
Front Matter....Pages 387-387
Toward a Meaningful Ecotoxicological Risk Assessment....Pages 389-393
Soil Pollution by Atrazine: Research on an Experimental Model....Pages 394-397
Ecotoxicological Effects of Artificial Smokes on a Terrestrial Microcosm....Pages 398-401
 Enchytraeus albidus (Enchytraeidae, Oligochaeta) as a Test Organism in Terrestrial Laboratory Systems....Pages 402-405
Front Matter....Pages 407-407
Comparative Assessment of Poly-L-Aspartic and Poly-L-Glutamic Acids as Protectants Against Aminoglycoside-induced Nephrotoxicity....Pages 409-412
Front Matter....Pages 407-407
Effect of Netilmicin and Amikacin on Urinary Phospholipids Excretion in Humans....Pages 413-416
Depletion of Cytochrome P-450 and Alterations in Activities of Drug Metabolizing Enzymes by S-(1,2-Dichlorovinyl)-L-Cysteine in Mouse Kidney Cortex....Pages 417-421
Purification and some Properties of Bolesatine, a Protein Inhibiting In Vitro Protein Synthesis, from the Mushroom Boletus Satanas Lenz (Boletaceae)....Pages 422-427
Eye and Skin Irritation Induced by Picolines....Pages 428-432
Canine Gingival Hyperplasia Induction and Recovery....Pages 433-435
Stress Hormone Changes after Toxic Doses of New Anticancer Drugs....Pages 436-439
Inhibition of Thyroid Hormone Transport in Plasma of Rats by Polychlorinated Biphenyls....Pages 440-445
Methyl Parathion Toxicity in Rats is Changed by Pretreatment with the Pesticides Chlordecone, Mirex and Linuron....Pages 446-447
Lack of Stress-Induced Neuroendocrine Changes after Prolonged Drinking of Acid Water in the Rat....Pages 448-451
Back Matter....Pages 453-463