Biological Aspects of Brain Tumors: Proceedings of the 8th Nikko Brain Tumor Conference, Karatsu (Saga) 1990

Front Matter....Pages I-XIX
Front Matter....Pages 1-1
An Introduction to Molecular Biology for the Neuro-Oncologist....Pages 3-17
Genetic Alterations of Nervous System Tumors....Pages 18-27
Activation of Proto-Oncogenes in Human Brain Tumors....Pages 28-37
Gene Structure and Regulatory Mechanism of Gene Expression....Pages 38-51
 In Situ Hybridization Using T-T Dimerized Non-Radioactive Probes....Pages 52-62
A Molecular Basis for Multidrug-Resistance and Reversal of the Resistance....Pages 63-72
The Extracellular Matrix: Cues from the Microcellular Environment Which Can Inhibit or Facilitate Glioma Cell Growth....Pages 73-86
Front Matter....Pages 87-87
Cell Kinetics of Brain Tumors and Its Clinical Relevance....Pages 90-95
Double-Labeling Method with BUdR and IUdR for Cell Kinetic Studies of Brain Tumors....Pages 96-101
Heterogeneous Cell Growth in Human Brain Tumors; an Analysis of the BrdU-Labeling Index and the NOR Histogram....Pages 102-107
Nucleolar Organizer Regions in Cultured Brain Tumor Cells....Pages 108-118
Rapid Assessment of Malignancy in Human Brain Tumors on Squash Preparations Using Nucleolar Organizer Region Staining....Pages 119-124
A Preliminary Report on the Use of Nucleolar Organizer Regions (NORs) Counting for Improved Surgical Resection of Glioblastomas....Pages 125-130
Evaluation of the Proliferation on Brain Tumor Cells and the Endothelial Cells of Tumor Vessels Using Immunohistochemical Study with Anti-BrdU Monoclonal Antibody and Factor VIII-Related Antigen....Pages 131-138
Weibel-Palade Bodies as a Marker for Endothelial Proliferative Potential of Human Glioma Capillaries....Pages 139-145
The Proliferative Potential After Hyperthermia and Irradiation on a Human Glioma Cell Line....Pages 146-150
PET Measurement of Tumor Metabolism in Patients with Gliomas....Pages 152-157
Malignancy of Glioma Estimated by PET- 18 F-FDG, PET- 11 C-Methionine, and SPECT- 201 Thallium....Pages 158-163
Metabolic Changes in a Glioma Model Following Chemotherapy....Pages 164-169
Quantitative Autoradiographical Evaluation of Protein Synthesis in a Brain Tumor Model Using 14 C-labeled Valine....Pages 170-176
Front Matter....Pages 87-87
Irradiation Effects on Tumor Blood Flow and Tumor Vascular Permeability in a Rat Transplanted Glioma Model: A Quantitative Autoradiographic Study....Pages 177-183
Superoxide Dismutase Activity in Experimental Brain Tumors — Determination by Electron Spin Resonance Spectrometry Using the Spin Trap Method....Pages 184-187
Studies of Active Oxygen Species in Brain Tumors....Pages 188-192
The Relationship Between Nucleolar Organizer Regions and Hormone-Producing Activity in Pituitary Adenoma....Pages 193-197
The Interaction Between Cytokines and Growth Factors on the Growth of Glioma Cells....Pages 200-206
Interferon Effect on Cytotoxicity of Autologous Stimulated Lymphocytes from Patients with Malignant Glioma....Pages 207-214
IL-2-Induced Signal Transduction in an Oligodendroglioma Line....Pages 215-220
Acute Effects of the Human Recombinant Tumor Necrosis Factor (rTNF) on the Cerebral Vasculature of the Rat in Both Normal Brain and an Experimental Glioma Model....Pages 221-228
PDGF-Related Proteins in Human Brain Tumors....Pages 229-234
Measuring the Effect of PDGF on Fibroblasts Using Glioma Cell Lines....Pages 235-243
Potentiation of 3-(4-Amino-2-Methyl-5-Pyrimidinyl) Methyl-1-(2-Chloroethyl)-Nitrosourea Cytotoxicity in Resistant Human Glioma Cell by Pretreatment with 5-(3-Methyl-1-Triazeno) Imidazole-4-Carboxamide....Pages 246-251
Potentiation of VP-16 Cytotoxicity by Dipyridamole in Malignant Glioma Cells....Pages 252-259
The Role of O 6 -Alkylguanine-DNA Alkyltransferase in Glioma in Resistance to Chloroethylnitrosoureas....Pages 260-265
O 6 -Methylguanine-DNA Methyltransferase (O 6 -MT) Activity as an Index of Drug Responsiveness to Antitumor Chloroethylnitrosoureas in Xenografted Brain Tumors....Pages 266-272
Cytokinetic Resistance of Malignant Glioma Cells: Antineoplastic Agents During Maintenance Therapy....Pages 273-280
Quantitative Analysis of Glutathione S-Transferase in Human Brain Tumors, C6 Rat Glioma Cells, and Drug Resistant C6 Cells....Pages 281-287
Glutathione S-Transferase Placental Form in Human and Rat Gliomas and Its Possible Role in Drug Resistance....Pages 288-294
Electrophoretical Analysis of DNA Topoisomerase I and II Expressions in Human Malignant Gliomas....Pages 295-298
Allele Loss on Chromosome 10 in Human Glioblastomas....Pages 300-305
Loss of Heterozygosity of Chromosomes 10 and 17 in Human Malignant Astrocytomas....Pages 306-310
Front Matter....Pages 87-87
Detection of p53 Gene Mutations in Human Brain Tumors by Single-strand Conformation Polymorphism Analysis of Polymerase Chain Reaction Products....Pages 311-316
An Analysis of Genetic Alterations of the p53 Gene in Human Glioma....Pages 317-324
The Expression and Structure of p53 Gene Products in Cultured Glioma Cells....Pages 325-331
Detection of Retinoblastoma Gene Aberrations in Human Brain Tumor by Single-Strand Conformation Polymorphism Analysis of Polymerase Chain Reaction Products....Pages 332-336
Oncogene Expression in Acoustic Neurinomas....Pages 337-342
Enhanced Expression of the c- myc Oncogenes in Human Brain Tumors....Pages 343-348
Restriction Fragment Length Polymorphism of the L- myc Gene and Gene Amplification in Meningiomas....Pages 349-354
DNA Aneuploid Cells Showing Discrepancy of Expression Between c- myc Oncogene Products and GFAP in Malignant Glioma....Pages 355-360
Oncogene Expression in High-Grade Astrocytomas: A Comparative Study of Immunogold-Silver and Peroxidase-Antiperoxidase Immunohistochemistry....Pages 361-365
Chromosomes and Clinical Features in 6 Cases of Gliomas....Pages 366-372
The Influence of MHC Class I Expression on the Growth of a Glioblastoma Cell Line....Pages 374-379
Association of Histocompatibility Antigen Expression with Intracerebral Tumorigenicity....Pages 380-385
Genetic Interaction Between Proto-Oncogene and Histocompatibility Antigen Gene Expressions in Cellular Differentiation of Mouse Neuroblastoma....Pages 386-390
Expression of Intermediate Filaments (GFAP and Vimentin) in Human Gliomas....Pages 391-395
Opposite Effects of Cyclic AMP and Cell Density on Expression of αB-Crystallin and Glial Fibrillary Acidic Protein in C-6 Glioma Cells....Pages 396-401
Demonstration of Microtubule-Associated Proteins in Human Gliomas....Pages 402-407
Human Malignant Glioma Cells Migrate to Fibronectin and Laminin: Role of Extracellular Matrix Components in Glioma Cell Invasion....Pages 408-415
The Effect of Matrigel on the Growth of Glioma Cells In Vitro and In Vivo ....Pages 416-420
Glycolipid in Human Glioma: Detection with Specific Antibodies and Its Application for Diagnosis of Gliomas....Pages 421-424
Immunohistochemical Study of Protein Kinase C Isozyme in Recurrent Cases of Malignant Glioma....Pages 425-429
Front Matter....Pages 87-87
Effects of Phorbor Esters on Cyclic AMP Accumulation in C6 Glioma Cells....Pages 430-435
Differentiation of a Medulloblastoma Cell Line Mediated by Protein Kinase A....Pages 436-441
Biological Characterization of Human Medulloblastoma (ONS-76 and ONS-81) Cell Lines....Pages 442-446
Murine Models with Leptomeningeal Dissemination of Human Medulloblastoma Cells....Pages 447-451
Antitumor Effects of Human Monoclonal Antibodies on Human Malignant Glioma Xenografts and Their Clinical Application....Pages 452-463
Effects of a Human Monoclonal Antibody and Cytokines on Human Malignant Glioma Cells....Pages 464-468
Antiproliferative Effect of Trapidil on a PDGF-Producing Glioma Cell Line In Vivo ....Pages 469-473
Effects of CDDP on a Monolayer Cultured 9 L Glioma Cell Line—Evaluation by a FCM Study of a Cellular DNA Histogram....Pages 474-478
Peripheral-Type Benzodiazepine Receptors in Gliomas....Pages 479-483
Peripheral-Type Benzodiazepine Receptors in Brain Tumors: In Vitro Binding Characteristics and Implication for New Image Analysis....Pages 484-493
Gadolinium Neutron Capture Therapy for Brain Tumors—Biological Aspects....Pages 494-499
Back Matter....Pages 501-503