Biological Activities of Polymers

Title Page......Page 1
Half Title Page......Page 3
Copyright......Page 4
ACS Symposium Series......Page 5
FOREWORD......Page 6
PdftkEmptyString......Page 0
PREFACE......Page 7
1 Perspectives in Bioactive Polymers......Page 9
History......Page 10
Complexity of Bioactive Polymers......Page 12
Modes of Bioactivity......Page 14
Advantages......Page 15
Literature Cited......Page 16
Experimental......Page 18
Variety of Available Polymers......Page 19
Tin Polydyes......Page 22
Polysaccharides Containing Tin......Page 26
Uranyl-Containing Compounds......Page 28
Literature Cited......Page 30
3 Biocidal Activity of Organotin Polymers in Wood......Page 31
Experimental......Page 32
Results and Discussion......Page 33
References......Page 37
4 Polymer-Bound Fungicides for Paints......Page 38
Fungicidal Monomer Synthesis......Page 40
Polymerizations......Page 43
Experimental Section......Page 48
General Procedure for Synthesis of Stable Lactices. Illustrated for Latex 1 (Table II).......Page 55
Literature Cited......Page 56
5 Poly(thiosemicarbazide) Copper(II) Complexes as Potential Algicides and Molluscicides......Page 57
Experimental......Page 60
Copper Release Experiments......Page 61
Computer Equilibrium Calculations......Page 66
Literature Cited......Page 75
6 Potential Polymeric Herbicides Derived from Poly(vinyl alcohol): Modification of Polymers1......Page 76
Experimental......Page 77
Discussion......Page 79
Literature Cited......Page 82
7 In Vivo Studies on Drug—Polymer Sustained-Release Systems......Page 84
Sustained Release of Gentamicin From Prosthetic Heart Valves......Page 85
Sustained Release of Tetracycline From HEMA/MMA Copolymers......Page 89
Literature Cited......Page 92
8 Polymeric Delivery Systems for Macromolecules Approaches for Studying In Vivo Release Kinetics and Designing Constant Rate Systems......Page 94
COMPARISON OF IN VITRO AND IN VIVO RELEASE KINETICS......Page 95
APPROACHES TO ACHIEVING ZERO-ORDER RELEASE KINETICS......Page 96
DISCUSSION......Page 100
Acknowledgments......Page 102
References......Page 103
9 Design of Polymeric Iron Chelators for Treating Iron Overload in Cooley's Anemia......Page 105
Design of Iron Chelators......Page 108
Polymeric Iron Chelators......Page 109
Potential Advantage of Polymeric Iron Chelators......Page 112
Literature Cited......Page 115
10 Structural and Functional Interrelationships of Anterior Pituitary Hormones......Page 116
ACTH and MSH......Page 117
LPH and EP......Page 120
Protein Hormones......Page 122
Growth Hormone (GH)......Page 123
Glycoprotein Hormones......Page 125
Acknowledgment......Page 126
Literature Cited......Page 127
11 Covalent Binding of Trypsin to Hydrogels......Page 130
Experimental......Page 131
Results and Discussion......Page 134
Literature Cited......Page 144
12 Chitin-Protein Complexes Ordered Biopolymer Composites......Page 146
Materials and Methods......Page 149
Results and Discussion......Page 150
Reconstruction of Electron Micrographs......Page 155
Literature Cited......Page 158
13 Interaction of Synthetic Polymers with Cell Membranes and Model Membrane Systems: Pyran Copolymer1......Page 160
Experimental......Page 161
Results and Discussion......Page 163
Literature Cited......Page 171
14 Thermodynamic Characterization of Proflavine Binding to DNA......Page 173
Spectral measurement......Page 174
Thermodynamic Quantities......Page 176
Conclusion......Page 183
Literature Cited......Page 185
Polymeric Drug Therapy......Page 186
Polyanionic Antineoplastic Polymers......Page 188
Nucleic Acid Analogs as Antineoplastic Polymers......Page 189
Other Antineoplastic Polymers......Page 192
Literature Cited......Page 194
16 The Antitumor and Antiviral Effects of Polycarboxylic Acid Polymers......Page 197
Antitumor and Antiviral Activity of Polycarboxylic Acid Polymers......Page 198
Toxicological Effects of Polycarboxylic Acid Polymers......Page 202
Macrophage Activation by Polycarboxyl Acid Polymer Immunopotentiators......Page 206
Literature Cited......Page 210
17 Polymeric Derivatives Based on cis-Diamminedichloroplatinum(II) as Antineoplastic Agents......Page 213
Synthesis and Physical Characterization......Page 215
Biological Testing......Page 216
Literature Cited......Page 222
18 Controlled Release of Anticancer Agents That Are Complexes of cis-Diamminedichloroplatinum(II) and α-Hydroxyquinones......Page 224
Experimental Section......Page 225
Results and Discussion......Page 227
In Vivo Experimental Results......Page 229
Literature Cited......Page 232
19 13C NMR Studies of the Structure of the Divinyl Ether-Maleic Anhydride Cyclic Alternating Copolymer: A Biologically Active Agent......Page 233
Results......Page 234
Discussion......Page 236
Literature Cited......Page 243
20 Interaction of Methotrexate (Polylysine) with Rat Liver Tumor Cells......Page 244
Experimental......Page 245
Results......Page 246
Discussion......Page 253
Literature Cited......Page 257
21 Evidence of Cooperativity and Allosterism in the Binding of Various Antibiotics and Carcinogens to DNA......Page 258
Materials and Methods......Page 261
Results and Discussion......Page 262
Literature Cited......Page 269
B......Page 271
D......Page 272
E......Page 273
H......Page 274
M......Page 275
P......Page 276
T......Page 278
X......Page 279