Biologic Rhythms in Clinical and Laboratory Medicine

Front Matter....Pages I-XVIII
Biologic Rhythms from Biblical to Modern Times. A Preface....Pages 1-5
Principles of Clinical Chronobiology....Pages 6-34
Cellular and Molecular Aspects of Circadian Oscillators: Models and Mechanisms for Biological Timekeeping....Pages 35-54
The Suprachiasmatic Nucleus and Other Pacemakers....Pages 55-64
Molecular and Genetic Aspects of Chronobiology....Pages 65-77
Seasonal and Daily Control of Enzyme Synthesis and Activity by Circadian Clocks....Pages 78-89
Data Processing in Chronobiological Studies....Pages 90-113
Chronopharmacology....Pages 114-137
Chronotoxicology....Pages 138-150
Rhythms in Drug-Induced Teratogenesis....Pages 151-157
Chronobiology of Pregnancy and the Perinatal Time Span....Pages 158-166
Patterns of Growth Hormone Release During Childhood and Adolescent Development in the Human....Pages 167-178
Rhythms in Biochemical Variables Related to Bone and Their Regulating Hormones....Pages 179-187
Biological Rhythms and Aging....Pages 188-207
Chronobiology of Mental Performance....Pages 208-213
Biological, Behavioral and Intellectual Activity Rhythms of the Child During Its Development in Different Educational Environments....Pages 214-229
Chronobiology of Physical Performance and Sports Medicine....Pages 230-242
Night and Shift Work and Transmeridian and Space Flights....Pages 243-255
Chronobiology of Human Sleep and Sleep Disorders....Pages 256-264
The Complex Circadian Pacemaker in Affective Disorders....Pages 265-276
Rhythmic and Nonrhythmic Modes of Anterior Pituitary Hormone Release in Man....Pages 277-291
Chronobiology of the Hypothalamic-Pituitary-Adrenal and Renin-Angiotensin-Aldosterone Systems....Pages 292-314
Chronobiology of the Hypothalamic-Pituitary-Gonadal Axis in Men and Women....Pages 315-329
Chronobiology of the Hypothalamic-Pituitary-Thyroid Axis....Pages 330-347
The Pineal....Pages 348-362
Chronobiology of Endocrine-Immune Interactions....Pages 363-374
Chronobiology, Nutrition, and Diabetes Mellitus....Pages 375-385
Endocrine and Neuroendocrine Axis Testing in Clinical Medicine: Evidence for Time Dependency....Pages 386-402
Biological Rhythms in Hepatic Drug Metabolism and Biliary Systems....Pages 403-409
Chronobiology of the Gastrointestinal System....Pages 410-417
Cardiovascular Chronobiology and Chronopharmacology....Pages 418-427
Chronobiologic Blood Pressure Assessment from Womb to Tomb....Pages 428-452
Nocturnal Asthma: Mechanisms and Chronotherapy....Pages 453-469
Renal Excretion: Rhythms in Physiology and Pathology....Pages 470-482
Inflammatory Reaction and Disease States....Pages 483-492
Chronobiology of Immune Functions: Cellular and Humoral Aspects....Pages 493-503
Chronobiology of Circulating Blood Cells and Platelets....Pages 504-526
Chronobiology of Human Bone Marrow....Pages 527-546
Chronobiology of Polymorphonuclear Leukocyte Migration....Pages 547-554
Chronobiology in Hemostastis....Pages 555-565
Normal and Abnormal Cell Proliferation in Mice Especially as It Relates to Cancer....Pages 566-599
Chronobiology of Endocrine and Endocrine-Responsive Tumors....Pages 600-610
Chronochemotherapy of Malignant Tumors: Temporal Aspects of Antineoplastic Drug Toxicity....Pages 611-634
Immune System in Relation to Cancer....Pages 635-647
Rhythms in Tumor Markers....Pages 648-657
Chronoepidemiology: Chronobiology and Epidemiology....Pages 658-672
Chronobiology in Laboratory Medicine....Pages 673-708
Back Matter....Pages 709-730