Bioinorganic Chemistry of Copper

Front Matter....Pages i-xvi
Front Matter....Pages 1-1
Electronic Structures of Active Sites in Copper Proteins: Coupled Binuclear and Trinuclear Cluster Sites....Pages 3-20
Pulsed EPR Studies of Copper Proteins....Pages 21-33
Copper(II) Complexes of Binucleating Macrocyclic Bis(Disulfide) Tetramine Ligands....Pages 34-47
Front Matter....Pages 49-49
Investigation of Type 1 Copper Site Geometry by Spectroscopy and Molecular Redesign....Pages 51-63
Metalloprotein Ligand Redesign: Characterization of Copper-Cysteinate Proteins Derived from Yeast Copper-Zinc Superoxide Dismutase....Pages 64-77
Electron Transfer Reactivity of Mutants of the Blue Copper Protein Plastocyanin....Pages 78-90
Studies of CNI Copper Coordination Compounds: What Determines the Electron-Transfer Rate of the Blue-Copper Proteins?....Pages 91-97
Front Matter....Pages 99-99
Chemical and Genetic Studies of Copper Resistance in E. coli ....Pages 101-109
Cuprous-Thiolate Polymetalic Clusters in Biology....Pages 110-123
Mechanisms of Copper Ion Homeostasis in Yeast....Pages 124-131
RNA Hydrolysis by Cu(II) Complexes: Toward Synthetic Ribonucleases and Ribozymes....Pages 132-139
Front Matter....Pages 141-141
Three-Dimensional Structure of the Oxygenated Form of the Hemocyanin Subunit II of Limulus Polyphemus at Atomic Resolution....Pages 143-150
New Probes of Oxygen Binding and Activation: Application to Dopamine β-Monooxygenase....Pages 151-163
Chemical and Spectroscopic Studies on Dopamine- β -Hydroxylase and other Copper Monooxygenases....Pages 164-183
The Copper Ions in the Membrane-Associated Methane Monooxygenase....Pages 184-195
The Enzymology of Peptide Amidation....Pages 196-209
Front Matter....Pages 211-211
Redox Decomposition Reactions of Copper(III) Peptide Complexes....Pages 213-221
Free Radical Induced Cleavage of Organic Molecules Catalyzed by Copper Ions — An Alternative Pathway for Biological Damage....Pages 222-235
Copper-Mediated Nitrogen Ligand Oxidation and Oxygenation....Pages 236-248
Front Matter....Pages 249-249
Synthesis, Structure and Properties of μ-η 2 :η 2 Peroxo Dinuclear Copper Complexes Modeling the Active Site of Oxyhemocyanin and Oxytyrosinase....Pages 251-263
Front Matter....Pages 249-249
Kinetics and Mechanisms of Cu I /O 2 Reactions....Pages 264-276
Functional Models for Hemocyanin and Copper Monooxygenases....Pages 277-291
Dioxygen Activation by Biomimetic Dinuclear Complexes....Pages 292-305
Oxidation Catalysis; A Dinuclear Approach....Pages 306-324
Dioxygen Activation and Transport by Dinuclear Copper(I) Macrocyclic Complexes....Pages 325-337
Imidazole-Ligated Copper Complexes: Synthesis, Structure, and Reactivity....Pages 338-347
Oxidation of Unactivated Hydrocarbons: Models for Tyrosinase and Dopamine β-Hydroxylase....Pages 348-362
Copper-Pteridine Chemistry. Structures, Properties, and Phenylalanine Hydroxylase Models....Pages 363-373
Design and Synthesis of Model Systems for Dioxygen Binding and Activation in Dinuclear Copper Proteins....Pages 374-381
Copper Dioxygenation Chemistry Relevant to Quercetin Dioxygenase....Pages 382-394
Front Matter....Pages 395-395
Two Crystal Forms of A. Cycloclastes Nitrite Reductase....Pages 397-405
Characterization of Mononuclear Copper-Nitrogen Oxide Complexes: Models of NO x Binding to Isolated Active Sites in Copper Proteins....Pages 406-418
The EPR-Detectable Copper of Nitrous Oxide Reductase as a Model for Cu A in Cytochrome c Oxidase: A Multifrequency Electron Paramagnetic Resonance Investigation....Pages 419-426
Mixed-Ligand, Non-Nitrosyl Cu(II) Complexes as Potential Pharmacological Agents via NO Release....Pages 427-436
Front Matter....Pages 437-437
Copper-Containing Enzymes: Structure and Mechanism....Pages 439-446
Active Site Ligand Interactions in Galactose Oxidase....Pages 447-458
Structure and Reactivity of Copper-Containing Amine Oxidases....Pages 459-470
Ascorbate Oxidase Structure and Chemistry....Pages 471-484
Cytochrome c Oxidase: A Brief Introduction and Some New Results from High Field Endor Studies of The Cu A and Cu B Sites....Pages 485-500
Back Matter....Pages 501-506