Bioenergetics: Molecular Biology, Biochemistry, and Pathology

Front Matter....Pages i-xii
Front Matter....Pages 1-1
Introductory Remarks....Pages 3-4
Opening Lecture....Pages 5-7
Front Matter....Pages 9-9
Memories of My Flavoprotein Research....Pages 11-22
Front Matter....Pages 23-23
An Overview of Ubiquinone Proteins....Pages 25-38
Studies on the Mechanism of Action of the Mitochondrial Energy-Linked Nicotinamide Nucleotide Transhydrogenase....Pages 39-48
Structures of Beef Mitochondrial Complex I Subunits....Pages 49-55
Inhibition of the Mitochondrial Complex I Activity by Fatty Acid Derivatives of Vanillylamide....Pages 57-63
New 4-Hydroxypyridine and 4-Hydroxyquinoline Derivatives as Inhibitors of NADH-Ubiquinone Oxidoreductase in the Respiratory Chain II....Pages 65-81
Effects of Redox State for Ubiquinone-10 on the Membrane Fluidity of Cardiolipin-Containing Liposomes....Pages 83-88
Features of Assembly and Mechanism of Yeast Mitochondrial Ubiquinol:Cytochrome C Oxidoreductase....Pages 89-109
Structural Studies of Euglena Cytochrome C 1 ....Pages 111-123
How Well is Cytochrome c Engineered?....Pages 125-145
Subunit I is the Catalytic Center of P. Denitrificans Cytochrome C Oxidase....Pages 147-154
The Separation between Cytochrome A and Cytochrome A 3 in the Absolute Spectrum....Pages 155-159
Which Electron-Transferring Reactions in the Respiratory Chain Contribute to the Energy Conservation?....Pages 163-170
Cytochrome Oxidase and Peroxide Metabolism....Pages 171-180
Do Hydrogen Ions Serve as Bioenergetic Messengers in Yeast?....Pages 181-190
Molecular Organization and Regulation of the Protonmotive System of Mammalian ATP Synthase....Pages 191-204
Situation of Archaebacterial ATPase among Ion-Translocating ATPases....Pages 205-216
Structure and Chemical Modification of Pig Gastric (H + +K + )-ATPase....Pages 217-225
Front Matter....Pages 23-23
Inhibition of the Uncoupler-Induced Mitochondrial ATP-Hydrolysis by the Cooperative Work of the ATPase Inhibitor, 9K Protein and 15K Protein....Pages 227-232
Reconstitution of H + ATPase into Planar Phospholipid Bilayers and Its Kinetic Analysis....Pages 233-240
A Mitochondrial Carrier Family for Solute Transport....Pages 241-249
The Calcium Pump of the Plasma Membrane: Structure/Function Relationships....Pages 251-258
The 9-kDa Polypeptide with Iron-Sulfur Centers A/B in Spinach Photosystem I with Special Reference to Its Structure and Topographic Consideration in Thylakoid Membrane....Pages 261-270
A Photo-Signal Transducing Photoreceptor (Stentorin) in Stentor coeruleus : A Brief Review....Pages 271-274
Theory and Applications of the Kinetics of Substrate Reaction during Irreversible Modification of Enzyme Activity....Pages 275-284
High Pressure Kinetic Studies on Certain Hemoproteins....Pages 285-293
The Purification and Properties of Glycerol-3-Phosphate Dehydrogenase in the Mitochondrial Inner Membrane....Pages 295-302
Front Matter....Pages 303-303
Subunit 8 of Yeast Mitochondrial ATP Synthase: Biochemical Genetics and Membrane Assembly....Pages 305-325
Gene Structure of Human ATP Synthase Beta Subunit....Pages 327-340
Molecule and Gene of Sulfolobus acidocaldarius ATPase....Pages 341-351
Nuclear Genes Encoding Two Subunits of Human Mitochondrial Cytochrome bc 1 Complex, Cytochrome c 1 and Ubiquinone-Binding Protein: Their Structural Organization of the 5′-Flanking Regions and Chromosomal Localization....Pages 353-362
Studies on the Function of the Mitochondrial Hinge Protein: Molecular Genetic Approach Using Yeast as a Model System....Pages 363-372
Molecular evolution and biology of human mitochondrial DNA....Pages 373-387
Front Matter....Pages 389-389
Stable and Unstable Bioenergetics in Vivo ....Pages 391-398
Regulation of Activity and Tissue-Specific Expression of Cytochrome C Oxidase Genes under Normal and Pathological Conditions....Pages 399-412
Mitochondrial DNA Mutations as an Etiology of Human Degenerative Diseases....Pages 413-427
Mitochondrial Myopathies: Morphological Approach to Molecular Abnormalities....Pages 429-439
S 1 Nuclease Analysis and Direct Sequencing of Deleted Mitochondrial DNA in Myopathic Patients: Role of Directly Repeated Sequences in Deletion....Pages 441-449
Front Matter....Pages 389-389
Thirty Years of Mitochondrial Pathophysiology: From Luft’s Disease to Oxygen Toxicity....Pages 451-465
Back Matter....Pages 467-484