Bioenergetics and Thermodynamics: Model Systems: Synthetic and Natural Chelates and Macrocycles as Models for Biological and Pharmaceutical Studies

Front Matter....Pages i-ix
Bioenergetics and Thermodynamics. Aims and Methodology of the School....Pages 1-6
Design of Peptide Molecules to Mimic the Metal Binding Sites of Proteins....Pages 7-16
Calorimetry and Biology....Pages 17-22
Bioinorganic Chemistry of Nickel....Pages 23-32
Design and Synthesis of Ligands....Pages 33-42
Holes, Handedness, Handles, and Hopes: Meeting the Requirements of Primary Binding, Chirality, Secondary Interactions and Functionality in Enzyme Analogues....Pages 43-62
Testing of Ligands....Pages 63-73
Calorimetric Techniques to Study Proton-Ligand and Metal-Ligand Interactions....Pages 75-91
Structural and Energetic Aspects of Metal-Ligand Binding....Pages 93-110
Transport of Metal Ions by Liquid Membranes Containing Macrocyclic Carriers....Pages 111-126
Enthalpy, Free-Energy, and Entropy Data for Structure-Activity Relationships in Acids and Bases....Pages 127-144
Potentiometric and Spectroscopic Determination of Equilibrium Constants....Pages 145-156
Experimental Data in Chemical and Biological Systems at Equilibrium....Pages 157-164
What Concentration Scale? What Standard State? What Species are Present?....Pages 165-174
Treatment and Analysis of Equilibrium Data by Computers....Pages 175-180
Mixed Complexes....Pages 181-205
Kinetics and Thermodynamics of Enzyme Action and Regulation....Pages 207-220
Computer Models of Biological Systems....Pages 221-227
Membranes, Alkali Metals and Transfer....Pages 229-251
Synthetic Solvent-Polymeric Membranes and their Transport Characteristics....Pages 253-274
Macrocycles and Cation Selectivity....Pages 275-296
Selectivity of Membranes towards Ions and Molecules....Pages 297-312
Transport Phenomena across Solid and Liquid Membranes....Pages 313-338
Carriers and Channels in Artificial and Biological Membranes....Pages 339-353
Lipid Bilayer Electrochemistry and Role of the Carriers....Pages 355-376
The Lipid Bilayer: A Model System for Biological Membranes....Pages 377-390
Differential Scanning Calorimetry. Processes Involving Proteins....Pages 391-396
Recent Advances in Biochemical Calorimetry....Pages 397-403
Interpretation of Calorimetric Data from Cooperative Systems....Pages 405-423
Selective Complexation of Ammonium and Guanidinium Salts by Synthetic Receptor Molecules....Pages 425-433
Dynamical Aspects of Small-Molecule Protein Interaction....Pages 435-452
Front Matter....Pages 453-453
Molecular Receptors, Carriers, and Catalysts: Design, Scope, and Prospects....Pages 455-461
Metal Ions in Biological Systems....Pages 463-464
Metal Ion — Protein Interactions in Solutions....Pages 465-466
Final Comments....Pages 467-471
Back Matter....Pages 473-474