Biochemical Basis of Medicine

Content: 
Front Matter, Page iii
Copyright, Page iv
Preface, Pages v-vi
Acknowledgements, Pages vii-x
Chapter 1 - Ultrastructure of the mammalian cell, Pages 3-17
Chapter 2 - Roles of extracellular and intracellular membranes: membrane structure and membrane transport, Pages 18-32
Chapter 3 - Role of subcellular organelles: lysosomes, Pages 33-42
Chapter 4 - Role of subcellular organelles: peroxisomes, Pages 43-45
Chapter 5 - Role of subcellular organelles: metabolism in the cytosol, Pages 46-53
Chapter 6 - Role of subcellular organelles: mitochondria and energy conservation, Pages 54-66
Chapter 7 - Role of subcellular organelles: inter-relationships of the mitochondria and cytosol, Pages 67-74
Chapter 8 - Role of subcellular organelles: the nucleus, Pages 75-82
Chapter 9 - Role of subcellular organelles: the endoplasmic reticulum, Pages 83-97
Chapter 10 - Nutrition: general aspects, Pages 101-115
Chapter 11 - Nutrition: energy requirements and the supply of energy by oxidation of foodstuffs, Pages 116-122
Chapter 12 - Nutrition: proteins in the diet, Pages 123-138
Chapter 13 - Nutrition: dietary fats, Pages 139-151
Chapter 14 - Nutrition: vitamins, Pages 152-169
Chapter 15 - Nutrition: inorganic constituents of the diet, Pages 170-174
Chapter 16 - Digestion and absorption of foodstuffs, Pages 175-195
Chapter 17 - Hormones: a summary of their structures and functions, Pages 196-220
Chapter 18 - Plasma glucose and its regulation, Pages 221-225
Chapter 19 - Plasma lipids and their regulation, Pages 226-245
Chapter 20 - Plasma amino acids and utilization of amino acids by the tissues, Pages 246-253
Chapter 21 - Plasma electrolytes, Pages 254-260
Chapter 22 - Plasma calcium and phosphate: regulation by vitamin D and parathyroid hormone, Pages 261-281
Chapter 23 - Starvation, Pages 282-291
Chapter 24 - Blood: erythropoiesis—role of folate and vitamin B12, Pages 295-307
Chapter 25 - Blood: metabolism in the red blood cell, Pages 308-315
Chapter 26 - Blood: blood clotting, Pages 316-333
Chapter 27 - Blood: catabolism of haemoglobin, Pages 334-343
Chapter 28 - Blood: iron and iron metabolism, Pages 344-358
Chapter 29 - Functions of the liver, Pages 359-368
Chapter 30 - The kidney, Pages 369-381
Chapter 31 - Muscle, Pages 382-394
Chapter 32 - Bone and collagen: calcification, Pages 395-411
Chapter 33 - The brain and the central nervous system, Pages 412-428
Chapter 34 - Toxicology: general aspects, Pages 431-432
Chapter 35 - Toxic metals, Pages 433-444
Chapter 36 - Metabolism of xenobiotics: xenobiochemistry, Pages 445-465
Chapter 37 - Alcohol: effects on metabolism, Pages 466-469
Chapter 38 - Chemical carcinogenesis, Pages 470-485
Chapter 39 - Biochemical diagnosis, Pages 489-499
Chapter 40 - An example of metabolic disturbance: obesity, Pages 500-510
Chapter 41 - Biochemical genetics: inborn errors of metabolism, Pages 511-520
Chapter 42 - Immunology, Pages 521-539
Chapter 43 - Principles of chemotherapy, Pages 540-558
Appendix 1 - Commonly occurring mono- and disaccharides, Pages 559-560
Appendix 2 - Polysaccharides—starch and glycogen, Page 561
Appendix 3 - Mucopolysaccharides—proteoglycans, Page 562
Appendix 4 - Naturally occurring α-amino acids, Page 563
Appendix 5 - Lipid chemistry and classification, Pages 564-565
Appendix 6 - Phospholipids, Pages 565-566
Appendix 7 - Unsaturated fatty acids and their metabolism, Page 567
Appendix 8 - Structure of the steroids and major inter-relationships, Page 568
Appendix 9 - Purine and pyrimidine bases, Page 569
Appendix 10 - Nucleosides—nucleotides, Page 570
Appendix 11 - Nucleic acid structure, Page 571
Appendix 12 - Classification and numbering of enzymes, Pages 571-575
Appendix 13a - Enzyme kinetics and enzyme inhibition, Pages 576-581
Appendix 13b - Example of the mechanism of action of an enzyme, Page 582
Appendix 14 - Glycolysis—outline of stages, Page 583
Appendix 15 - Glycolysis, Page 584
Appendix 16 - Pentose phosphate pathway—outline of stages, Page 585
Appendix 17 - Citric acid cycle—ATP formation, Page 586
Appendix 18 - Citric acid cycle—structures of intermediates, Page 587
Appendix 19 - Citric acid cycle—links with amino acid metabolism, Page 588
Appendix 20 - β-Oxidation of fatty acids, Page 589
Appendix 21 - The electron transport chain, Page 590
Appendix 22 - Steroid synthesis: biosynthesis of cholesterol, Page 591
Appendix 23 - Purine metabolism, Page 592
Appendix 24 - Summary of amino acid metabolism, Page 593
Appendix 25 - Ornithine cycle—synthesis of urea, Page 594
Appendix 26 - Synthesis of DNA, Page 595
Appendix 27 - Replication of DNA: formation of Okazaki fragments, Page 596
Appendix 28 - Metabolic compartmentation of protein synthesis, Page 597
Appendix 29 - The genetic code, Page 598
Appendix 30 - The genetic code-relationships of amino acid structure to coding symbol, Page 599
Appendix 31 - Transfer RNAs, Page 600
Appendix 32 - Protein synthesis, Page 601
Further Reading, Pages 603-609
Index, Pages 611-631