Biochemical and Clinical Aspects of Hemoglobin Abnormalities

Content: 
Front Matter, Page iii
Copyright, Page iv
LIST OF CONTRIBUTORS, Pages xi-xvii
PREFACE, Pages xix-xx
ROLE OF DISTAL RESIDUES IN STRUCTURE, LIGAND BINDING, AND OXIDATION OF HEMOGLOBINS A, ZÜRICH, AND SYDNEY, Pages 1-15, P.W. Tucker, S.E.V. Phillips, M.F. Perutz, R.A. Houtchens, W.S. Caughey
PROPERTIES AND REACTION MECHANISM OF Hb ZÜRICH (α2β2HIS(63) → ARG), Pages 17-28, M. Brunori, E. Antonini, G. Giacometti, E. Di Iorio, K.H. Winterhalter
LIGAND BINDING TO HEMOGLOBINS: EFFECTS OF GLOBIN STRUCTURE, Pages 29-56, Winslow S. Caughey, Robert A. Houtchens, Amos Lanir, John C. Maxwell, Samuel Charache
FUNCTIONAL ABNORMALITIES OF WHOLE BLOOD IN SICKLE CELL ANEMIA, Pages 57-66, Robert M. Bookchin, Yoshihiro Ueda, Ronald L. Nagel, Leon C. Landau
HEMOSTATIC ALTERATIONS IN SICKLE CELL ANEMIA, Pages 67-76, Harold S. Ballard
ASSESSMENT OF THE CLINICAL SEVERITY OF SICKLE CELL DISEASE, Pages 77-91, Jeanne A. Smith, Yusuf Khakoo, Hillard Davis
LOCATION OF THE HEME IRON ATOMS AND CHARACTERIZATION OF THE QUATERNARY STRUCTURE OF THE CARBONMONOXY-β4 TETRAMER, Pages 93-107, Arthur Arnone, Patrick D. Briley
HEMOGLOBIN ENGINEERING: CONSEQUENCES OF ALTERATIONS AT FUNCTIONALLY SENSITIVE SITES PARTICULARLY SUSCEPTIBLE TO CHEMICAL OR ENZYMATIC ATTACK, Pages 109-122, Joseph Bonaventura, Celia Bonaventura, George Lapennas
DISCUSSION: Following a Paper on “THE OXYGEN BINDING IN ABNORMAL COBALT MYOGLOBINS AND HEMOGLOBINS”, Pages 123-127, Takashi Yonetani
AMINO ACIDS AND PEPTIDES AS INHIBITORS OF SICKLE HEMOGLOBIN GELATION, Pages 129-141, A.N. Schechter, C.T. Noguchi, W.A. Schwartz
EFFECT OF DBA ON HEMOGLOBIN SS CELLS AND HEMOGLOBIN BIOSYNTHESIS, Pages 143-149, Clayton L. Natta, Valeria Balogh-Nair, Koji Nakanishi
PROGRESS IN THE NATURAL HISTORY STUDIES OF THE CLINICAL SEVERITY OF SICKLE CELL DISEASE: EPIDEMIOLOGIC ASPECTS, Pages 151-164, Darleen F. Powars, Walter A. Schroeder
INTERMOLECULAR INTERACTIONS IN CRYSTALS OF HUMAN DEOXY HEMOGLOBINS A, C, F AND S, Pages 165-177, Warner E. Love, Paula M.D. Fitzgerald, Jonathan C. Hanson, William E. Royer Jr., William M. Ringle
PROTON NUCLEAR MAGNETIC RESONANCE STUDIES OF SICKLE CELL HEMOGLOBIN, Pages 179-193, Chien Ho, Irina M. Russu
AREAS OF INTERACTION IN THE HbS POLYMER, Pages 195-203, Ronald L. Nagel, Robert M. Bookchin
GLYCOSYLATED HEMOGLOBINS, Pages 205-214, R. Flückiger, K.H. Winterhalter
GLYCOSYLATION OF HUMAN HEMOGLOBIN, Pages 215-226, H. Franklin Bunn, Melisenda J. McDonald
EVALUATION OF THE POOL OF α HEMOGLOBIN CHAINS AND STUDY OF THE DISSOCIATION OF THE HEMOGLOBIN MOLECULE INTO MONOMERS, Pages 227-235, Y. Beuzard, F. Molko, J. Cacheleux, A. Tsapis
INHIBITION OF SICKLING BY CYSTAMINE, Pages 237-249, Y. Beuzard, P. Machado, W. Hassan, I. Max-Audit, M.C. Garel, J. Rosa
PROGRESS IN INTERPRETING THE PHASE TRANSITIONS OF SICKLE-CELL HEMOGLOBIN, Pages 251-278, Jacinto Steinhardt, Steve Kowalczykowski, Maryann McD. Jones
CIRCULAR DICHROISM PROBES OF HEMOGLOBIN STRUCTURE, Pages 279-298, Robert Woody
CONFORMATIONAL EFFECTS OF THE HbS MUTATION, Pages 299-310, Clara Fronticelli, Enrico Bucci
ELECTRON MICROSCOPY OF FIBERS AND CRYSTALS OF A DEOXYGENATED PLATINUM DERIVATIVE OF HEMOGLOBIN S, Pages 311-322, S.L. White, T.E. Wellems, S.D. Fuller, J.M. Quinn, M.W. Makinen
OPTICAL DETECTION OF HEME LIGAND CONFIGURATION IN SPERM WHALE MYOGLOBIN, Pages 323-334, A.K. Churg, R.S. Danziger, M.W. Makinen
THE ROLE OF SPECTRIN AND ACTIN IN IRREVERSIBLY SICKLED CELLS: UNSICKLING OF “IRREVERSIBLY” SICKLED GHOSTS BY CONDITIONS WHICH INTERFERE WITH SPECTRIN-ACTIN POLYMERIZATION, Pages 335-352, Samuel E. Lux, Kathryn M. John
SPECTRIN ASSEMBLY IN IRREVERSIBLY SICKLED CELL MEMBRANES: ROLE OF CALCIUM AND ATP, Pages 353-367, J. Palek, S.C. Liu, P.A. Liu
HEMOGLOBIN INTERACTIONS AND WHOLE BLOOD OXYGEN EQUILIBRIUM CURVES IN SICKLING DISORDERS, Pages 369-388, Robert M. Winslow
DETERMINATION OF THE STRUCTURE OF THE FIBERS OF HEMOGLOBIN S BY ELECTRON MICROSCOPY AND THREE-DIMENSIONAL IMAGE RECONSTRUCTION, Pages 389-399, Gene Dykes, Richard H. Crepeau, Stuart J. Edelstein
FUNCTIONAL IDENTITY OF HEMOGLOBINS S AND A IN THE ABSENCE OF POLYMERIZATION, Pages 401-411, Russell R. Pennelly, Robert W. Noble
THE APPARENT ABSENCE OF A LIGAND-LINKED STRUCTURAL TRANSITION IN THE REGION OF THE β6 VALINE OF HEMOGLOBIN S, Pages 413-419, Robin A. Karol, Margaret Harris, Robert W. Noble
LIGAND BINDING AND THE GELATION OF SICKLE CELL HEMOGLOBIN, Pages 421-441, James Hofrichter
SUCCESSES AND FAILURES OF A SIMPLE NUCLEATION THEORY FOR SICKLE CELL HEMOGLOBIN GELATION, Pages 443-457, William A. Eaton, James Hofrichter
REDOX SYSTEM: IRON(II)-IRON(III) INTERCONVERSION IN OXYGEN-CARRYING PROTEINS, Pages 459-474, Z. Bradić, R. Conrad, D.R. Eaton, P.C. Harrington, E. Olivas, D.J.A. de Waal, R.G. Wilkins
MECHANISMS FOR HEMOGLOBIN OXIDATION: THE RESPONSE OF ABNORMAL HUMAN AND OTHER HEMOGLOBINS TO DIFFERENT OXIDATIVE PATHWAYS, Pages 475-493, W.J. Wallace, R.A. Houtchens, J.M. Holt, W.S. Caughey
OXIDATION OF OXYHEMOGLOBIN BY REDUCTANTS, Pages 495-503, C.E. Castro, Ruth S. Wade, N.O. Belser
CROSSINGS OVER VERSUS POINT MUTATIONS AS CAUSES OF HEMOGLOBIN VARIANTS AND POSSIBLY OF THALASSEMIAS, Pages 505-508, Hermann Lehmann
HEMOGLOBIN AND THE RED CELL MEMBRANE, Pages 509-513, Helen M. Ranney, Nurith Shaklai, Juan Yguerabide
STRUCTURAL ASPECTS OF HEMOGLOBIN FUNCTION, Pages 515-525, Martin Karplus
EFFECTS OF HEME IRON LIGANDS ON SELF-ASSOCIATION OF βSH CHAINS, Pages 527-533, Roland Valdes Jr., Gary K. Ackers
ALLOSTERIC BINDING HEAT EFFECTS OF HbA AND HbM IWATE, Pages 535-543, S.J. Gill, H.T. Gaud
ANALYSIS OF OXYGEN EQUILIBRIA IN SYNTHETIC AND NATURAL MUTANT VALENCE HYBRID HEMOGLOBINS: IMPLICATIONS FOR MODELS OF HEME-HEME INTERACTION IN NORMAL HEMOGLOBIN, Pages 545-557, Allen P. Minton
THE KINETICS OF OXYGEN BINDING TO HUMAN RED BLOOD CELLS, Pages 559-576, J. Thaddeus Coin, John S. Olson
MEASUREMENT OF HOMEOSTATIC RESPONSES TO ALTERED P50 IN PATIENTS WITH ABNORMAL HEMOGLOBINS, Pages 577-581, Samuel Charache
OXIDATION OF HUMAN HEMOGLOBIN BY COPPER: SPECIFICITY FOR BETA CHAINS AND FORMATION OF MODIFIED PRECURSOR, Pages 583-589, R.W. Carrell, R. Krishnamoorthy, C.C. Winterbourn
DICHLOROMETHANE AS AN ANTISICKLING AGENT IN SICKLE CELL HEMOGLOBIN, Pages 591-605, Benno P. Schoenborn, Barry E. North
FOURIER TRANSFORM INFRARED SPECTROSCOPY OF HEMOGLOBIN, Pages 607-617, James O. Alben, George H. Bare, Patrick P. Moh
A COMPARATIVE EPR STUDY OF HEMOGLOBINS A AND KANSAS: SPECTRAL SIGNATURES OF AFFINITY STATES, Pages 619-628, J. Peisach, W.E. Blumberg
IONIC AND NON-IONIC EFFECTS ON THE SOLUBILITY OF DEOXYHEMOGLOBIN S, Pages 629-646, Philip D. Ross, S. Subramanian
ANIONIC CONTROL OF HEMOGLOBIN FUNCTION, Pages 647-663, Celia Bonaventura, Joseph Bonaventura
INHIBITION OF ERYTHROCYTE SICKLING IN VITRO BY GLYCERALDEHYDE, Pages 665-685, James M. Manning, Alan M. Nigen
MAJOR SITES FOR THE OXYGEN-LINKED BINDING OF CHLORIDE TO HEMOGLOBIN, Pages 687-694, James M. Manning, Alan M. Nigen, Samuel Charache, James O. Alben
EFFECTORS OF THE RATE OF DEOXYHEMOGLOBIN S POLYMERIZATION, Pages 695-715, G. Larry Cottam, Katsunori Shibata, Michael R. Waterman
INDEX, Pages 717-725