Basic clinical radiobiology

Content: Introduction: the significance of radiobiology and radiotherapy for cancer treatment --
Irradiation-induced damage and the DNA damage response --
Cell death after irradiation: how, when and why cells die --
Quantifying cell kill and cell survival --
Radiation dose-response relationships --
Linear energy transfer and relative biological effectiveness --
Physics of radiation therapy for the radiobiologist --
Tumour growth and respnse to radiation --
Fractionation: the linear-quadratic approach --
The linear-quadratic approach in clinical practice --
Modified fractionation --
Time factors in normal tissue responses to irradiation --
The dose-rate effect --
Pathogenesis of normal tissue side effects --
Stem cells in radiotherapy --
Normal tissue tolerance and the effect of dose inhomogeneities --
The oxygen effect and therapeutic approaches to tumor hypoxia --
The tumour microenvironment and cellular hypoxia responses --
Combined radiotherapy and chemotherapy --
Molecular targeted agents for enhancing tumour response --
Biological individulisation of radiotherapy --
Molecular image guided radiotherapy --
Retreatment tolerance of normal tissues --
Biological response modification of normal tissue reactions: basic principles and pitfalls --
Hadron therapy: the clinical aspects --
Tissue response models --
Second cancers after radiotherapy.