Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors

Content: 
Series Editors
Page i

Editorial Board
Page ii

Volume Editors
Page iii

Copyright
Page iv

Contributors
Page ix

Preface
Pages xi-xii
Erkki Nissinen

Introductory Remarks: Catechol-O-Methyltransferase Inhibition—An Innovative Approach To Enhance l-Dopa Therapy In Parkinson\'S Disease With Dual Enzyme Inhibition
Pages 1-5
Erkki Nissinen

The Catechol-O-Methyltransferase Gene: Its Regulation and Polymorphisms
Pages 7-27
Elizabeth M. Tunbridge

Distribution and Functions of Catechol-O-Methyltransferase Proteins: Do Recent Findings Change The Picture?
Pages 29-47
Timo T. Myöhänen, Pekka T. Männistö

Catechol-O-Methyltransferase Enzyme: Cofactor S-Adenosyl-l-Methionine And Related Mechanisms
Pages 49-71
Thomas Müller

Biochemistry and Pharmacology of Catechol-O-Methyltransferase Inhibitors
Pages 73-118
Erkki Nissinen, Pekka T. Männistö

The Chemistry of Catechol-O-Methyltransferase Inhibitors
Pages 119-162
David A. Learmonth, László E. Kiss, Patrício Soares-da-Silva

Toxicology and Safety of Comt Inhibitors
Pages 163-189
Kristiina Haasio

Catechol-O-Methyltransferase Inhibitors in Preclinical Models as Adjuncts of l-Dopa Treatment
Pages 191-205
Concepció Marin, J.A. Obeso

Problems with the Present Inhibitors and a Relevance of New and Improved COMT Inhibitors in Parkinson’s Disease
Pages 207-225
Seppo Kaakkola

Catechol-O-Methyltransferase and Pain
Pages 227-279
Oleg Kambur, Pekka T. Männistö

Index
Pages 281-290

Contents of Recent Volumes
Pages 291-323