Azapropazone: 20 years of clinical use

Front Matter....Pages ii-xi
Front Matter....Pages 1-1
Introduction to therapy with azapropazone....Pages 3-8
The chemical classification of azapropazone....Pages 9-19
Survey of toxicological investigations of azapropazone....Pages 21-29
The mode of action of azapropazone in relation to its therapeutic actions in rheumatic conditions and its major side-effects....Pages 31-52
Pharmacokinetics of azpapropazone in comparison to other NSAIDs....Pages 53-61
The pharmacokinetics of azapropazone....Pages 63-80
Mathematical model for assessing risk of gastrointestinal reactions to NSAIDs....Pages 81-93
Reduction of irreversible injury in animal models of myocardial ischaemia by treatment with azapropazone....Pages 95-106
Dual inhibitory effects of azapropazone on both neutrophil migration and function: relation to cardiovascular protection....Pages 107-122
Aspects of clinical pharmacology and bioavailability of azapropazone....Pages 123-150
Immunochemical studies on azapropazone....Pages 151-159
Front Matter....Pages 161-161
Untersuchungen zur Arthrose [Studies in osteoarthritis]....Pages 163-173
Azapropazone in gout and hyperuricaemia....Pages 175-184
Die Analgetische Wirksamkeit von Azapropazon [Analgesic effects of azapropazone]....Pages 185-201
Überblick über die Anwendung von Azapropazon nach operativen Eingriffen und bei traumatisierten Patienten [Review of application of azapropazone in post-operative and traumatic conditions]....Pages 203-217
Clinical trial methodology in rheumatoid arthritis: azapropazone studies....Pages 219-237
Comparative effects of azapropazone on the progression of joint pathology in osteoarthritis....Pages 239-253
Serious gastrointestinal reactions to azapropazone: an estimate of the risk....Pages 255-263
Tolerance of azapropazone: allergic and pseudo-allergic reactions and comparison with other NSAIDs....Pages 265-273
Haematological reactions....Pages 275-279
Front Matter....Pages 161-161
Epilogue, with some thoughts for research on azapropazone....Pages 281-289
Back Matter....Pages 291-295