Attention, Genes and ADHD

Cover
Half Title
Title Page
Copyright Page
Dedication
Table of Contents
List of Contributors
Preface
Acknowledgements
1: Introduction
2: Introduction to the Genetic Analysis of Attentional Disorders
	The Aims of Behaviour Genetics
	Why are People Different?
	The Tools of Behaviour Genetics
	An Example of Genetic Analysis of ADHD
	Is ADHD a Continuum or a Discrete Category?
	Discussion
	References
3: The Diagnostic Genetics of ADHD Symptoms and Subtypes
	Introduction
	Diagnostic Genetics
	Categorical Versus Dimensional Systems
	Heritability
	Australian Twin ADHD Project (ATAP)
	Concordance Data
	Genetic Analysis
	Item Analysis
	Univariate Item Analysis
	Multivariate Item Analysis
	Discussion
	References
4: The Developmental Genetics of ADHD
	Introduction
	Stability and Changes in Symptomatology
	The Long-Term Outcome of ADHD
	Psychopathology in Adult Relatives of Young People with ADHD
	Trends in Molecular Studies
	Discussion
	References
5: Familial and Genetic Bases of Speech and Language Disorders
	The Search for Phenotype Definitions
	Studies of Phenotypes
	Incidence/Prevalence
	Gender as a Risk Factor
	Familial Aggregation
	Studies that Suggest a Genetic Component/Genetic Studies
	Comorbid Disorders
	Pilot Data
	Genetic Explanations
	Summary
	References
6: Comorbidity of Reading/Spelling Disability and ADHD
	Defining Reading and Spelling Disabilities
	Epidemiological Evidence for the High Comorbidity of ADHD and RSD
	Quantitative Genetic Studies of RSD
	Molecular Genetic Studies of RSD
	Evidence for Shared Genetic Influences on ADHD and RSD
	Conclusions
	References
7: Causes of the Overlap Among Symptoms of ADHD, Oppositional Defiant Disorder, and Conduct Disorder
	Method
	Results
	Discussion
	References
8: Aetiology of the Sex Difference in the Prevalence of DSM-III-R ADHD: A Comparison of Two Models
	Differences Between ADHD Boys and Girls
	Sex Differences in the Prevalence of ADHD
	Present Study
	Results
	Discussion
	References
9: Single Gene Studies of ADHD
	Introduction
	Genetics
	Molecular Studies
	Recent Studies Investigating Single Genes
	Gene to Brain
	Fragile-X Syndrome
	References
10: Molecular Genetics of ADHD
	Introduction
	Characterisation of the ADHD Phenotype for Genetic Studies
	Design of Studies for Molecular Genetics
	Molecular Genetics
	Genetic Data Analyses
	Molecular Genetic Studies of ADHD
	Summary and Future Directions
	References
11: The Genetic Relationship Between ADHD and Gilles De La Tourette Syndrome
	Phenomenology and Natural History of ADHD
	Neuropsychological Assessment of GTS and ADHD
	Molecular Genetic Studies of GTS and ADHD
	Summary
	References
12: Implications of Genetic Studies of Attention Problems for Education and Intervention
	Diagnosis
	Comorbidity
	Intervention
	Family Dynamics
	Language and ADHD
	Comorbidity and Schooling
	Implications of Molecular Genetics
	Ethical Issues
	Agenda for Psychiatric Genetics
	Conclusion
	References
13: Child Psychiatry in the Era Following Sequencing the Genome
	Introduction
	Clinical Concepts
	Genetic Risk Mechanisms
	Searching for Susceptibility Genes
	Finding Out What Genes Do
	Clinical Benefits of Genetic Research
	Diagnosis
	Conclusion
	References
Author Index
Subject Index