Atherosclerosis VI: Proceedings of the Sixth International Symposium

Front Matter....Pages I-XXVIII
Front Matter....Pages 1-1
Atherosclerosis. The Major Problem in Man....Pages 3-11
Clinical Aspects of Atherosclerosis — Recent Advances in Diagnosis and Evaluation of Coronary Heart Disease....Pages 12-22
Recent Advances in Diagnosis and Evaluation. Peripheral Artery Disease....Pages 23-28
Atherosclerosis. Recent Advances in Diagnosis and Evaluation — Cerebrovascular Disease....Pages 29-33
Clinical Aspects of Atherosclerosis. Role of Coronary Artery Spasm....Pages 34-40
Conservative Treatment of Coronary Heart Disease....Pages 41-46
Conservative Treatment of Peripheral Artery Disease....Pages 47-51
An Introduction to Atherosclerosis in Children....Pages 55-59
Clinical and Anatomic Correlates of Cardiovascular Disease in Children from the Bogalusa Heart Study....Pages 60-65
Dietary Prevention of Atherosclerosis in Childhood....Pages 66-70
Early Indicators for the Risk of Atherogenesis. A Field Test of a New Methodology on German and Japanese Kindergarten Children in Düsseldorf....Pages 71-76
Morphologic Changes in Coronary Arteries of Children in Different Geographic Locations....Pages 77-81
Structure and Ultrastructure of the Coronary Artery Intima in Children and Young Adults Up to Age 29....Pages 82-86
The Natural History of Aortic Atherosclerosis in Children, Adolescents and Young Adults....Pages 87-94
Immunohistology of Aortic Fatty Streaks in Children and Adults....Pages 95-98
Heterogeneity of Genetic Transmission of Familial Hypercholesterolemia (F. H.) from Direct Parents in 20 Families of Homozygotes Type IIa....Pages 101-105
The Impact of Analbuminemia on Lipid Transport and Lipoproteins....Pages 106-110
Familial Hypertriglyceridemia: Incidence, Genetics and Possible Defect in Cellular Metabolism....Pages 111-113
Phytosterolemia....Pages 114-118
Familial Chylomicronaemia Due to a Circulating Inhibitor of Lipoprotein Lipase....Pages 119-122
Front Matter....Pages 1-1
Experimental Nonhuman Primate Atherosclerosis....Pages 125-129
Platelets and Atherogenesis in Normal and von Willebrand Disease Pigs....Pages 130-134
Lipid Accumulation in the Rabbit Aortic Wall in Response to Injury....Pages 135-139
WHHL Rabbit. A Heritable Animal Model of Familial Hypercholesterolemia....Pages 140-143
Hypertensive Rat Models of Atherosclerosis....Pages 144-148
Seeking for More Similarity Between Animal Models and Human Atherosclerosis....Pages 149-149
Lipoproteins, Blood Cells and Endothelial Integrity in Atherosclerosis: What Role for Eicosanoids?....Pages 150-150
Chairman’s Comments on the Discussion at the Workshop on Measurement of Atherosclerosis....Pages 153-154
Measurement of Regression in Atherosclerosis....Pages 155-159
Measurement of Monotypism in Atherosclerosis....Pages 160-164
Measurement of Human Atherosclerosis....Pages 165-169
Identification of the Gelatinous Lesion....Pages 170-173
Quantitation of Certain Qualitative Differences in the Atherosclerotic Process....Pages 174-179
Chairman’s Introduction to Workshop on Regression....Pages 183-186
Preliminary Report on Coronary Lesions and Serum Lipids Before and After 2 Years Dietary Intervention in 22 Patients....Pages 187-196
Measurement of Atherosclerosis by Arteriography and Microdensitometry: Model and Clinical Investigations....Pages 197-201
Role of Macrophages in Regression of Swine Atherosclerosis....Pages 202-206
Potential for Atherosclerosis Regression in Perspective....Pages 207-211
The Biochemical Basis for Anatomical Regression of Atherosclerosis....Pages 212-216
The Endothelial Changes During Regression of Atherosclerotic Lesions in Animal Models....Pages 217-220
Front Matter....Pages 1-1
Diet and Carcinogenesis....Pages 223-227
Effects of Dietary Cholesterol and Saturated Fat on the Appearance of HDLc in Peripheral and Cardic Lymph....Pages 228-232
Dietary Fibres for Prevention of CVD....Pages 233-237
Dietary Cholesterol and Plasma Lipoproteins....Pages 238-241
Experience with Soybean Protein Diets in Treating Hypercholesterolemias....Pages 242-246
Dietary Fatty Acids as Prostaglandin Precursors....Pages 247-250
Effects of Dietary Treatment on Lipoplitic Activities and Lipids and Apolipoproteins in Patiens with Uremia....Pages 251-255
Introduction....Pages 259-261
Therapeutical Effects of Endurance Training in Primary Hyperlipoproteinemia....Pages 262-267
Atherosclerotic Disease in Non-Human Primates: Its Prevention and Regression by Moderate Conditioning Exercise....Pages 268-270
The Effect of Different Types of Exercise on Serum Lipids....Pages 271-275
Physical Exercise as Protection Against Heart Attack....Pages 276-280
Exercise and Fibrinolysis....Pages 281-285
Regulation of Serum Triglycerides in Trained Subjects....Pages 286-289
Exercise and Arachidonic Acid Metabolites: Effect of Adrenergic Beta Blockade....Pages 290-290
Effect of Physical Training on Blood Pressure and Serum Lipoproteins in Middle-Aged Men with Borderline Hypertension....Pages 291-291
The Treatment of Hyperlipaemia by Gemfibrozil: A Comparison with Clofibrate....Pages 295-299
Lipid-Lowering Agents and Apolipoproteins B, A-I and A-II — A Long-term Study....Pages 300-305
Compliance and Cholestorol-Lowering in Clinical Trials: Efficacy of Diet....Pages 306-310
Long-Term Treatment of Hypercholesterolaemia with Guar Gum: Comparison with Probucol....Pages 311-314
Front Matter....Pages 1-1
Gross Endothelial Layer Blistering and Vascular Injury....Pages 317-321
Haemodynamic Influences on Platelets in Haemostasis and Thrombosis....Pages 322-326
Effect of Stresses on the Uptake of Material by the Arterial Wall....Pages 327-330
Percutaneous Transluminal Angioplasty in the Treatment of Peripheral Vascular Disease....Pages 331-335
Metabolic and Haemodynamic Effects of Plasma-Exchange in Familial Hypercholesterolemia....Pages 336-340
Front Matter....Pages 341-341
Role of Endothelial Dysfunction in Vivo in Smooth Muscle Proliferation....Pages 343-349
Derivation and Progression of Atherosclerotic Plaques....Pages 350-360
Hemodynamics as a Factor in Lesion Localization....Pages 361-369
Role of Connective Tissue in the Arterio-Atherosclerotic Process. Interest of a Cell-Matrix Directed Pharmacology....Pages 370-380
Arterial Wall Cells and Mitogens....Pages 381-382
The Microcarrier Co-Culture System: Interactions Between Endothelial and Smooth Muscle Cells In Vitro....Pages 385-389
Intermediate Filaments of the Vascular Wall....Pages 390-394
A Putative Mechanism for the Conversion of Aortic Smooth Muscle Cells into Foam Cells that Bypasses the Autoregulatory LDL Receptor-Mediated Process....Pages 395-399
Structure and Function of Arterial Smooth Muscle Cells....Pages 400-400
Altered Growth Stimulation and LDL Degradation in Human Arterial Smooth Muscle Cells (ASMC) and Fibroblasts (F) by Low Molecular Weight Serum Factors from Typre II Diabetics....Pages 401-402
Platelet-Derived Growth Factors: Properties and Biologic Activities....Pages 405-409
Preparation and Characterisation of Platelet-Derived Growth Factor....Pages 410-415
Effects of PDGF and Endothelial Cell Products on Cellular Lipid and Lipoprotein Metabolism in Human Fibroblasts....Pages 416-420
Site of Action of LCAT in Plasma....Pages 423-427
The Isolation and Partial Characterisation of Two Lipid Transfer Proteins (LTP-I and LTP-II), Each of Which Facilitates the Transfer of Esterified Cholesterol, Triglyceride and Phospholipid Between Plasma Lipoproteins....Pages 428-431
Front Matter....Pages 341-341
Besides Blockage of the Synthesis of HMG-CoA Reductase, Cycloheximide also Inhibits its Degradation....Pages 432-435
Intestinal HMG-CoA Reductase: Regulation and Function....Pages 436-440
Fluid-Phase Pinocytosis in Arterial Smooth Muscle Cells....Pages 443-447
Interaction of Platelets, Macrophages and Lipoproteins in Relation to Atherogenes....Pages 448-451
Role of Macrophage Foam Cells in Arterial Lesions....Pages 452-456
Chemotactic Responses of Monocyte-Macrophages. A Possible Mechanism for Their Migration into Atherosclerotic Lesions....Pages 457-461
Macrophages in Coronary Artery and Aortic Intima and in Atherosclerotic Lesions of Children and Young Adults up to Age 29....Pages 462-466
Front Matter....Pages 467-467
Structure-Function Relationships in the Plasma Lipoproteins....Pages 469-479
Metabolism of Triglyceride-Rich Lipoproteins....Pages 480-488
Apolipoprotein E and Cholesterol Metabolsim....Pages 489-501
Selective Removal of Plasma Low-Density Lipoproteins by Combined Extracorporeal Plasma Separation-Immunoadsorption....Pages 502-507
Apolipoprotein Mutants and Apolipoprotein Disorders....Pages 511-515
Determination of Plasma Apolipoprotein Profiles....Pages 516-521
The Plasma Cholesterol: Cholesterol-Ester Cycle....Pages 522-526
Pathogenesis of Secondary Hyperlipoproteinemia....Pages 527-532
Surface Organization of the Apolipoproteins of Plasma High Density Lipoproteins and Relevance to Functions....Pages 533-536
Receptor Interactions of Human Apolipoprotein E....Pages 537-542
Effects of Hormones on Plasma Lipoprotein Concentrations....Pages 543-547
Monoclonal Antibody as a Probe for Structural and Functional Studies of the LDL Receptor....Pages 551-552
The Role of Receptors in Apolipoprotein B Metabolism....Pages 553-558
Front Matter....Pages 467-467
Factors Influencing Receptor-Mediated Low Density Lipoprotein Catabolism....Pages 559-563
Rat and Human Lipoprotein Utilization by Cultured Rat Ovary Granulosa Cells....Pages 564-568
Contribution of Apoprotein B Production Rate in the Regulation of Lipoprotein Levels in Man....Pages 571-575
Measurements of C Apoprotein Kinetics in Man....Pages 576-579
Regulation of Rat Liver Apolipoprotein E mRNA and Cloning of Its cDNA....Pages 580-584
Effect of LP-X on Hepatic Cholesterol Synthesis....Pages 585-590
Apolipoprotein Research: A Multidisciplinary Task....Pages 593-594
Significance of Apolipoproteins for the Biochemical Profile of Atherosclerosis....Pages 595-597
Regulation of Lipoprotein Gene Expression....Pages 598-601
Apolipoprotein AIV Metabolism in Man....Pages 602-605
Mechanism of Action of Lipoprotein Lipase: Role of Apolipoprotein C-II....Pages 606-610
Human Apolipoprotein Mutants....Pages 611-615
Use of Specific Antibodies in the Study of the Function of Lipoprotein Lipase....Pages 619-622
The Role of Hepatic Triglyceride Lipase in Primates....Pages 623-627
Function of Hepatic Endothelial Lipase in Lipoprotein Metabolism....Pages 628-632
Genetic Regulation of Lipoprotein Lipase....Pages 633-635
Lipoprotein Lipase: Apolipoprotein C-II Interactions Studied by Fluorescence and Monoclonal Antibodies....Pages 636-639
Front Matter....Pages 641-641
Arachidonic Acid Metabolism in Human Platelets....Pages 643-648
Factors Influencing the Growth, Stability and Fate of Arterial Thrombi....Pages 649-658
Biosynthesis and Some Biological Properties of Prostaglandins and Leukotrienes....Pages 659-668
Front Matter....Pages 641-641
Interactions Between Lipoproteins and PGI 2 Under Physiologic and Pathophysiologic Conditions....Pages 669-675
Effects of Platelet-Derived Growth Factor on the Metabolism of Glycerolipids and Arachidonic Acid in Cultured Cells....Pages 679-683
The Phosphatidylinositol Response and the Activation of Platelets....Pages 684-688
Platelet Phospholipid Fatty Acids and Platelet Aggregation....Pages 689-693
Regulatory Function of the Cellular Thiol-Disulfide Status in the Metabolic Control of Human Blood Platelet Aggregation....Pages 694-698
The Formation of Eicosanoids During Inflammation....Pages 701-703
Prostaglandins, Cyclic Nucleotides and Atherosclerosis....Pages 704-708
Prostacyclin Formation, Plasma Factor, Platelet Sensitivity and Prostacyclin Degradation in Coronary Heart Disease....Pages 709-714
Vascular Resistance and Platelet Function on Cardiovascular Drugs and Diets Affecting Prostanoid Formation....Pages 715-720
Front Matter....Pages 721-721
Coronary Heart Disease — Geographical Differences and Time Trends....Pages 723-732
Coronary Disease Risk Factors: A Population View....Pages 733-744
Pediatric Precursors of Atherosclerosis....Pages 745-758
Intervention on Single Risk Factors: Hyperlipoproteinemia....Pages 759-766
Intervention of Single Risk Factor: Hypertension....Pages 767-771
Intervention of Single Risk Factors of Atherosclerosis: Thrombosis....Pages 772-782
Intervention on Smoking: An Individual and Collective Challenge....Pages 783-790
Multiple Risk Factor Intervention Trials....Pages 791-795
Pharmacological Approach to the Prevention of Atherosclerosis....Pages 796-804
Role of Lipid Profiles in Assessing Atherogenesis....Pages 807-810
Plasma Lipids and Lipoprotein Cholesterol Distributions and US-USSR Steering Committee for Cardiovascular Area I: Pathogenesis of Atherosclerosis....Pages 811-815
Front Matter....Pages 721-721
The Belgian Heart Disease Prevention Project: Six Years Coronary Risk Factor Evolution....Pages 816-820
Pecularities of Coronary Heart Disease in the French Population....Pages 821-825
The Fate of the Patient with OPAD Detected at an Early Stage. Preliminary Data on an 11-year Follow-up of 239 Men with OPAD and 239 Controls....Pages 826-829
Population Attributable Events — Implications for Prevention....Pages 830-834
Risk Factors in Insulin Dependent Diabetics....Pages 835-835
Contribution to the Discussion....Pages 836-836
Cardiovascular Epidemiology and Preventive Community Programmes in Austria....Pages 837-837
Clinical Associations of Hypocholesterolaemia....Pages 841-846
On a Possible Inverse Relationship Between Plasma Cholesterol and the Risk of Cancer. The Framingham Study....Pages 847-851
Cholesterol and Steroid Hormone Metabolism in Abetalipoproteinemia....Pages 852-856
Associations Between Plasma Cholesterol, Cell Membrane Composition and Fluidity, and Retinoid Concentrations in a Normal Male Population....Pages 857-861
The Prognostic Significance of Hypocholesterolemia in Hospitalized Patients....Pages 862-864
The Association of Low Serum Cholesterol Level to the Risk of Cancer. Significance with Respect to Dietary Modification for Coronary Heart Disease Prevention....Pages 865-867
Serum Cholesterol and Cancer Mortality in White Males: Social Class Effects, Evans County Twenty Year Follow-Up Study....Pages 868-872
Carbon Monoxide and Atherosclerosis....Pages 875-877
The Influence of Smoking on Plasmalipoproteins....Pages 878-882
Smoking and Atherosclerotic Disease. The Oslo Study....Pages 883-887
Epidemiology of Cardiovascular Disease in Different Countries in Relation to Smoking....Pages 888-892
Smoking and Atherosclerosis: Risk Factor Reduction....Pages 893-898
Nicotine and Atherosclerosis....Pages 899-902
Front Matter....Pages 721-721
Smoking: A Pediatric Disease....Pages 903-907
Smoking and Lipid Metabolism....Pages 908-908
The Influence of Smoking on Systolic and Diastolic Blood Pressure....Pages 909-910
Current Japanese Situations on Secondary Prevention and Lipid Lowering Drugs....Pages 913-919
Serum Lipid Lowering in Secondary Prevention: A Review....Pages 920-925
A Controlled Trial of Substantial Reduction of Plasma Lipids in Symptomatic Atherosclerosis: An Angiographic Study....Pages 926-929
Program on the Surgical Control of the Hyperlipidemias (Posch). A Secondary Intervention Trial — 4-Year Lipid Results....Pages 930-935
Platelet-Vessel Wall Interactions in Human and Experimental Hypercholesterolemia....Pages 936-941
Secondary Prevention of Ischaemic Heart Disease by the Combined Treatment with Clofibrate and Nicotinic Acid....Pages 942-944
Front Matter....Pages 945-945
Introduction....Pages 947-948
Diabetes Mellitus and Obesity....Pages 949-951
Hypertension in Obesity....Pages 952-954
Surgical Risks in Obese Patients....Pages 955-959
Obesity and Lipoprotein Metabolism....Pages 960-963
Another Look at Body Weight, Health and Longevity....Pages 964-966
Status of a Computerized, Angiographic Regression Trial (CLAS)....Pages 969-971
Back Matter....Pages 973-984