Atherosclerosis V: Proceedings of the Fifth International Symposium

Front Matter....Pages i-xxxix
Front Matter....Pages 1-2
Atherosclerosis: Patterns and Rates of Progression....Pages 3-7
Surgery for Coronary Artery Disease....Pages 8-16
Review of 30 Years of Surgery of the Heart and the Great Vessels....Pages 17-25
Mechanism of Progress. Page from the History of Cardiovascular Surgery....Pages 26-34
My Current Views Regarding Coronary Bypass Surgery....Pages 35-39
Results of Coronary Bypass: A Long-Term Perspective....Pages 40-42
Current Views Regarding Coronary Bypass Surgery....Pages 43-46
Comparison of Medical and Surgical Mortality in a High Risk Subset of Coronary Patients with Extreme Degrees of Exercise-Induced Ischemia....Pages 47-51
Introduction to Epidemiology of Atherosclerotic Lesions....Pages 52-53
Epidemiology of Coronary Atherosclerosis: Postmortem vs Clinical Risk Factor Correlations. The Framingham Study....Pages 54-56
Risk Factors for Coronary and Cerebral Atherosclerosis in the Oslo Study....Pages 57-62
Atherosclerosis and Its Risk Factors Among Hawaii Japanese....Pages 63-66
Atherosclerosis, Smoking and Other Risk Factors....Pages 67-70
Drug Treatment of Hyperlipidemias....Pages 71-73
Drug Treatment of Type II Hyperlipoproteinemia. Effects on Plasma Lipid and Lipoprotein Levels....Pages 74-77
Synergism in Drug Treatment of Familial Hypercholesterolemia....Pages 78-82
Effect of Plasma Lipoextraction and Infusion of Heterologous HDL on the Development of Experimental Atherosclerosis in Rabbits....Pages 83-85
New Drug Treatments in Hyperlipidaemia....Pages 86-89
Apoprotein Changes Following Treatments with Hypolipidemic Drugs....Pages 90-93
Milieu and Function of Arterial Wall—The Clues to Unique Reactivity....Pages 94-97
Front Matter....Pages 1-2
Atherogenetic Factors Intrinsic to the Artery Wall....Pages 98-102
Arterial Endothelium in the Initial Stages of Atherogenesis....Pages 103-111
Ultrastructure of the Normal Arterial Endothelium and Intima....Pages 112-120
Biochemical Studies on Permeability and the Interaction Between Blood Constituents and Arterial Components in Atherosclerosis....Pages 121-125
Smooth Muscle Cells in Atherosclerosis....Pages 126-129
Mononuclear Phagocytes in Atherosclerosis....Pages 130-132
Altered Permeability in Atherosclerosis—Morphological Evidence....Pages 133-135
The Elastic Element in the Arterial Wall: Biosynthesis and Degradation....Pages 136-139
Prostacyclin Production by Vascular Smooth Muscle and Endothelial Cells....Pages 140-143
Lipid, Apoprotein and Lipoprotein Origin and Synthesis....Pages 144-145
Origin in Plasma of Low Density and High Density Lipoproteins....Pages 146-151
Biological and Biochemical Aspects of ML-236B (Compactin) and Monacolin K, Specific Competitive Inhibitors of 3-hydroxy-3-methylglutaryl Coenzyme A Reductase....Pages 152-155
Biosynthesis of Rat Apolipoprotein E....Pages 156-159
Apoprotein Secretion from the Human Intestine....Pages 160-163
Nascent VLDL and Nascent HDL from Liver....Pages 164-167
Synthesis and Secretion of Very Low Density Lipoprotein by Cultured Rat Hepatocytes....Pages 168-172
Topochemical Studies on Human High Density Lipoprotein....Pages 173-175
The Associating System of Small Subunits in ApoLDL....Pages 176-179
Lipoprotein Structure and the Mechanism of Action of Lipoprotein Lipase....Pages 180-183
Structure of High Density Lipoproteins....Pages 184-188
Front Matter....Pages 1-2
Cholesteryl Ester-Rich Very Low Density Lipoproteins: Magnetic Resonance Studies....Pages 189-196
Front Matter....Pages 197-198
Dietary Prevention of Coronary Artery Disease—A Policy Overview....Pages 199-208
Dietary Prevention of Coronary Heart Disease....Pages 209-218
Evaluation of the Evidence Relating National Dietary Patterns to Disease....Pages 219-219
Diet-Lipid-Atherosclerosis Relationship: Epidemiological Evidence and Public Health Implications....Pages 220-234
Dietary Prevention of Coronary Heart Disease: The Role of Essential Fatty Acids....Pages 235-243
Identification of Children Who Are Heterozygotes for Familial Hypercholesterolaemia....Pages 244-249
Lipoprotein and Apoprotein, Adipose Tissue and Hepatic Lipoprotein Lipase Levels in Patients with Familial Hyperchylomicronemia and their Immediate Family Members....Pages 250-254
Studies of a Large French-Canadian Kindred with Two Forms of Hyperlipoproteinemia....Pages 255-259
The Complex Genetics of Type III Hyperlipoproteinemia: Influence of Co-inherited Monogenic Hyperlipidemia upon the Phenotypic Expression of Apolipoprotein E3 Deficiency....Pages 260-263
Prevalence of Hyperlipoproteinemia in Selected North American Populations....Pages 264-267
Hypercholesterolemia Type IIa: Incidence of Secondary, of Familial and of Non-Familial Forms in Central Europe....Pages 268-271
Clues to Mechanisms of Cardiovascular Disease from an Epidemiologic Study of Children—The Bogalusa Heart Study....Pages 272-277
Cigarette Smoking: A Risk Factor for Atherosclerosis in Childhood?....Pages 278-281
Nutrient Intake, Lipids, and Lipoproteins in 6–19-Year-Old Schoolchildren....Pages 282-285
Pediatric Lipoprotein Metabolism and Atherosclerosis: A Prospectus....Pages 286-293
Tracking of Coronary Risk Factors in Children: The Muscatine Study....Pages 294-301
Risk Factors in Children: Role of Hereditary Hyperlipoproteinemia....Pages 302-304
Diet Treatment of Atherosclerosis....Pages 305-306
Body Weight, Dietary Fat, Hyperlipidemia, and Coronary Heart Disease....Pages 307-310
Front Matter....Pages 197-198
Effects of Dietary Fiber on Serum Lipids and Cholesterol Metabolism in Man....Pages 311-315
Effects of Dietary Changes on Plasma Lipoprotein Lipids....Pages 316-319
Hypolipidemic Diets and Biliary Lipid Composition....Pages 320-323
Interaction of Genetic and Environmental Factors Causing Atherosclerosis by Immunologic Mechanisms....Pages 324-329
Immunologic Arterial Injury and Atherogenesis....Pages 330-333
Autoimmune Hyperlipidemia and Autoimmune Xanthomatosis....Pages 334-336
Tobacco, Immunologic Injury, and Cardiovascular Disease....Pages 337-339
Immunoregulatory Lipoproteins, Viral Hepatitis, and Cancer....Pages 340-343
Regulation of Pathways of Lymphocyte Differentiation by the Serum Lipoprotein: LDL-In....Pages 344-347
Autoimmune Mechanisms in the Development of Atherosclerosis....Pages 348-350
Nutritional Factors in Atherosclerosis....Pages 351-354
Cholesterol-Induced Hyperlipoproteinemia and Atherosclerosis in Dogs, Swine and Monkeys: Models for Human Atherosclerosis....Pages 355-358
Dietary Animal Models for Studying Cardiovascular Disease Risk Factors....Pages 359-364
Transformation of Naturally Occurring Quiescent Intimal Smooth Muscle Cell Masses into Atherosclerotic Lesions in Swine Fed a Hyperlipidemic Diet....Pages 365-368
Reversal of Atherosclerosis: Comparison of Non-Human Primate Models....Pages 369-374
Triglyceride Hydrolysis by Lipoprotein Lipase Bound to Endothelial Cells in Culture....Pages 375-378
LDL-mediated Endocytosis and Cholesteryl Ester Transfer—Alternative Metabolic Pathways for the Regulation of Cellular Cholesterol Synthesis....Pages 379-382
Mode of Action of the Hepatic Endothelial Lipase: Recycling Endocytosis via Coated Pits....Pages 383-386
Lipoprotein Lipase and Hepatic Endothelial Lipase are Key Enzymes in the Metabolism of Plasma High Density Lipoproteins, Particularly of HDL 2 ....Pages 387-392
How Does Lipoprotein Lipase Bind to Substrate Lipoproteins and How Is Its Activity Regulated?....Pages 393-396
Front Matter....Pages 197-198
Activation of Lipoprotein Lipase by Synthetic Fragments of ApoC-II....Pages 397-400
Front Matter....Pages 401-402
The Vessel Wall and Atherosclerosis....Pages 403-406
The Artery Wall and the Pathogenesis of Progressive Atherosclerosis....Pages 407-414
Endothelial Dysfunction and the Pathogenesis of Atherosclerosis....Pages 415-425
Prostacyclin and Thromboxane A 2 in Platelet Vessel Wall Interactions....Pages 426-441
The Platelet-Derived Growth Factor....Pages 442-449
Portacaval Shunt for Type II Hyperlipidemia....Pages 450-453
Combined Medico-Surgical Strategy for Severe Familial Hypercholesterolaemia....Pages 454-457
Plasma Exchange in the Treatment of Familial Hypercholesterolemia....Pages 458-461
Partial Ileal Bypass: A Test of the Lipid-Atherosclerosis Hypothesis....Pages 462-465
Selective Removal of Low Density Lipoproteins from Blood by Affinity Chromatography....Pages 466-469
Comparison of Cholestyramine, Ileal By-Pass and Portacaval Shunt in the Treatment of Familial Hypercholesterolemia....Pages 470-473
Homozygous Hypercholesterolemia; Treatment by Portacaval Shunt....Pages 474-477
High Density Lipoproteins: An Overview....Pages 478-483
Role of HDL in Individual Prediction and Community Prevention of Coronary Heart Disease....Pages 484-487
Cross-Cultural, Ethnic, Demographic, and Environmental Factors Affecting High Density Lipoprotein Cholesterol and Their Mutual Interrelationships with Coronary Heart Disease....Pages 488-494
Epidemiology and High Density Lipoproteins....Pages 495-499
HDL Cholesterol, Tissue Cholesterol and Coronary Atherosclerosis: Epidemiological Correlations....Pages 500-503
The Multiple Risk Factor Intervention Trial....Pages 504-508
Test of the Lipid Hypothesis: The Coronary Primary Prevention Trial (CPPT) of the Lipid Research Clinics Program....Pages 509-512
Front Matter....Pages 401-402
The Chicago Heart Health Curriculum Program....Pages 513-519
Summary of Concepts Concerning the Arterial Wall and Its Atherosclerotic Lesions....Pages 520-524
Transport of Macromolecules Across the Artery Wall....Pages 525-528
Cholesteryl Ester-Rich Lipid Inclusions in the Development of Experimental Atherosclerosis in Rabbits....Pages 529-532
Low Density Lipoproteins in the Aorta: Relation to Atherosclerosis....Pages 533-536
Cyclic Nucleotides and Atherosclerosis....Pages 537-540
Differences in the Metabolism of Abnormal Atherogenic Low Density Lipoproteins from O-Cholesterol-Fed Nonhuman Primates by Cells in Culture....Pages 541-545
Factor VIII/Willebrand Factor and the Interaction of Blood Platelets with Subendothelium....Pages 546-549
Do Platelets Contribute to Atherogenesis?....Pages 550-556
Platelet and Endothelial Alterations in Experimental Arteriosclerosis....Pages 557-562
Endothelium in Experimental Atherosclerosis....Pages 563-566
Smooth Muscle Cell Kinetics in Vivo: A Comparative Study....Pages 567-569
Turnover and Metabolism of Body Cholesterol in Humans....Pages 570-575
Turnover of Very Low Density Lipoprotein Proteins....Pages 576-579
Low Density Lipoprotein Metabolism in Familial Hypercholesterolemia....Pages 580-585
Metabolism of Very Low Density Lipoprotein-Triglyceride in Man....Pages 586-590
Effect of Drugs on High Density Lipoprotein Metabolism....Pages 591-595
Liver and Cholesteryl Ester Transfer Amongst Lipoprotein—One Suggested Model....Pages 596-599
Role of Chylomicrons in Atherogenesis....Pages 600-603
Front Matter....Pages 605-606
Relationship Between the Properties of the Apo B Containing Low-Density Lipoproteins (LDL) of Normolipidemic Rhesus Monkeys and their Mitogenic Action on Arterial Smooth Muscle Cells Grown In Vitro....Pages 607-615
Front Matter....Pages 605-606
Lipoprotein Structure and Metabolism: Inhomogeneity, Variability and Species Specificity....Pages 616-623
Structure and Function of the Human Plasma Apolipoproteins....Pages 624-630
Enzymatic Regulation of Lipoprotein Catabolism....Pages 631-640
Cholesterol Feeding: Effects on Lipoprotein Structure and Metabolism....Pages 641-652
Metabolism of Plasma Lipoproteins....Pages 653-665
Possible Mechanisms of Lipid Storage in Tangier Disease....Pages 666-670
Introduction to Deficiencies of Apolipoproteins CII and EIII With Some Associated Clinical Findings....Pages 671-674
Apolipoprotein CII Deficiency....Pages 675-679
Tangier Disease....Pages 680-683
Abetalipoproteinemia and Hypobetalipoproteinemia: Questions Still Exceed Insights....Pages 684-688
Polymorphism of Apolipoprotein E....Pages 689-694
Renin Sodium Profiling and Vasoconstriction Volume Analysis of Hypertensive Patients. A New Era for Diagnosis and Treatment....Pages 695-698
Aortic Endothelial Changes During the Development and Reversal of Experimental Hypertension....Pages 699-702
Atherosclerosis and Its Risk Factors in Japan....Pages 703-706
Controlled Therapeutic Trial in Mild Hypertension—Initial Results....Pages 707-711
Clinical and Pathogenic Relevance of Erythrocyte Cation Fluxes Measurement in Human Hypertension....Pages 712-714
Estimated Rates of Progression and Regression of Human Femoral and Coronary Atherosclerosis in 45-Year-Old Men....Pages 715-718
Community Pathology of Atherosclerosis and Coronary Heart Disease in New Orleans: Relationship of Risk Factors to Atherosclerotic Lesions....Pages 719-730
Regression Sequences After Experimental Atherosclerosis....Pages 731-734
Changes in Atherosclerotic Lesions Following Surgical Cholesterol Reduction....Pages 735-738
Front Matter....Pages 605-606
Approaches to the Study of Atherosclerosis Regression in Rhesus Monkeys: Interpretation of Morphometric Measurements of Coronary Arteries....Pages 739-748
Regression of Advanced Atherosclerotic Lesions in Swine....Pages 749-752
Differences in the Degradation-Rate of Intracellular Lipid Droplets in the Intimal Smooth Muscle Cells and Macrophages of Regressing Atherosclerotic Lesions of Primates....Pages 753-756
Quantitating Rhesus Monkey Atherosclerosis Progression and Regression with Time....Pages 757-761
Prostacyclin and Atherosclerosis—A Hypothesis....Pages 762-765
Modulation by Prostaglandins of Vascular Reactivity to Adrenergic Stimuli....Pages 766-771
Prostaglandins, Thrombin Receptors and Platelet Aggregation in Normal and Hypercholesterolemic Subjects....Pages 772-775
Prostaglandins, Thromboxanes and Leukotrienes....Pages 776-783
Role of Hormones Associated with Atherogenesis in Modulating Cellular Metabolism of Lipoproteins....Pages 784-786
Platelet Production of Pathological LDL....Pages 787-790
Modulation of Cellular Cholesterol Metabolism by LCAT Treated Lipoproteins....Pages 791-795
Deposition and Hydrolysis of Cytoplasmic Triglyceride and Cholesterol Ester in Aortic Smooth Muscle Cells in Culture....Pages 796-799
The Role of the Liver in LDL Catabolism....Pages 800-803
Standardization of Apolipoprotein Immunoassays by an Isotope Dilution Method....Pages 804-806
Rate-Nephelometry of A-I and Electrophoresis....Pages 807-810
Methodological Considerations in Apolipoprotein Immunoassay....Pages 811-815
Plasma Levels of Some Apolipoproteins in Human Atherosclerosis....Pages 816-819
Quantitation of C Apolipoprotein Metabolism in Human Subjects....Pages 820-823
Quantitation of Apolipoproteins C-II and C-III in Plasma....Pages 824-828
Addendum....Pages 829-830
Back Matter....Pages 831-843