Atherosclerosis IV: Proceedings of the Fourth International Symposium

Front Matter....Pages I-XLVI
Front Matter....Pages XLVII-XLVII
Arterial Endothelial Permeability to Macromolecules....Pages 1-11
The Maintenance of Endothelial Integrity....Pages 12-15
Arterial Smooth Muscle Cells in Atherogenesis: Births, Deaths and Clonal Phenomena....Pages 16-23
Lipoproteins — Steady State Aspects....Pages 24-29
Connective Tissue in Atherosclerosis....Pages 30-35
Immunologic Mechanism of Atherosclerosis....Pages 36-44
Introduction....Pages 45-46
Uptake of Serum Lipoproteins into the Arterial Wall....Pages 46-48
Enzymes Catalyzing Phospholipid-Dependent Transacylations in the Arterial Wall....Pages 48-51
Heparin-Manganese Precipitability of Canine Lipoproteins as Correlated with Binding to the Cell Surface Receptors on Fibroblasts....Pages 52-56
Synthesis and Removal of Free Cholesterol and of Cholesterol Ester by Smooth Muscle Cells in Tissue Culture....Pages 57-62
Abstract....Pages 63-72
Possibilities of Hyaline Formation in the Vessel Wall, Light- and Electron Microscopic Structure: Problems of Nomenclature....Pages 73-79
Hypertension, Stroke and Atherogenesis in Experimental Models....Pages 79-83
Hypertension and Cerebral Atherosclerosis....Pages 83-87
Abstracts....Pages 88-91
An Introduction to the Epidemiology of Atherosclerosis....Pages 92-98
Association between Risk Factors and Atherosclerotic Lesions Based on Autopsy Findings in the Oslo Study: A Preliminary Report....Pages 98-102
Atherosclerosis and Risk Factors....Pages 102-104
Coronary Risk Factors in Adults: The Influence of Nutrition in Early Life....Pages 104-108
Front Matter....Pages XLVII-XLVII
The Relation of Ante Mortem Factors to Atherosclerosis at Necropsy....Pages 108-113
Atherosclerosis and its Risk Factors in the Hawaiian Japanese....Pages 113-116
Atherosclerosis in Relation to Personal Attributes of a Japanese Population in Homes for the Aged....Pages 116-120
Frequency of Coronary and Peripheral Artery Disease in Hyperlipoproteinemia....Pages 120-123
Concluding Remarks on the Epidemiology of Atherosclerosis....Pages 124-124
Abstracts....Pages 125-128
Kinetics of VLDL Subfractions....Pages 129-132
Comparison of Methods of Plasma Triglyceride Turnover....Pages 132-137
The Intravenous Fat Tolerance Test with Intralipid — Validity, Applications, and Limitations....Pages 137-141
Triglyceride Turnover in Diabetic States of Dogs....Pages 141-145
Abstracts....Pages 146-148
Epidemiological Research in Japan on Smoking and Cardiovascular Diseases....Pages 149-156
Atherogenic Compounds of Tobacco Smoke....Pages 156-161
Abnormalities Potentially Mediating the Effect of Cigarette Smoking on Atherosclerosis....Pages 161-165
Oxygen Transport and Smoking....Pages 165-166
The Evidence for Nicotine as an Etiological Factor in Cardiovascular Disease (CVD)....Pages 167-169
Abstracts....Pages 170-173
Front Matter....Pages 175-175
Structure of the Plasma Lipoproteins — A Review....Pages 177-188
Cellular Catabolism of Serum Lipoproteins....Pages 189-191
Synthesis and Secretion of Plasma Lipoproteins and Apo-Lipoproteins....Pages 192-196
Front Matter....Pages 175-175
Dynamics of Lipoprotein Interconversion....Pages 197-204
Lipoprotein Metabolism in Tissue Culture....Pages 205-208
Current Concepts of Hyperlipoproteinemia....Pages 209-219
Electroimmunoassays of Serum Apolipoproteins in Normolipidemic Subjects and Patients with Primary Hyperlipoproteinemias....Pages 220-222
Lipid Organization in Human Plasma Low-Density Lipoproteins....Pages 222-227
Formation and Structural Properties of Lipoprotein-X....Pages 228-233
Isothermal Calorimetric Studies on Human HDL Apolipoproteins....Pages 233-237
High-Density Lipoprotein Abnormalities Associated with Disease....Pages 238-241
On the Role of Apolipoprotein A-I in the Structure of Serum High-Density Lipoproteins (HDL)....Pages 241-246
Abstracts....Pages 247-258
Requirement for Regression Studies in Animal Models....Pages 259-263
The Effect of Strenuous Exercise on Plasma Lipids and Atherosclerosis in Cholesterol-Fed Cockerels....Pages 263-268
Changes of Cyclic Nucleotides in the Regressive Course of Experimental Atherosclerosis and their Modification by Sex Hormones and Phthalazinol....Pages 268-273
Model of Arterial Injury by Balloon De-Endothelialization: Reappraisal, Improvement, and Application to Measurement of Endothelial Growth....Pages 273-274
Reversibility of Atherosclerosis in Pyridoxine-Deficient Monkeys....Pages 275-278
Regression of Atherosclerosis at Plasma Cholesterol Concentrations Achievable in Man....Pages 278-280
Aortic Atherosclerosis of Primates....Pages 280-285
Abstracts....Pages 286-292
Cholesterol Metabolism in High- and Low-Responding Rhesus Monkeys....Pages 293-298
Relationships Between Metabolism of Cholesterol and the Turnover of Plasma Lipoproteins....Pages 298-301
Front Matter....Pages 175-175
Studies on the Mechanism of Development of Hypercholesterolemia: Effect of Aging and Genetic Factors in Animal Models....Pages 301-304
Cholesterol Synthesis in Slowly Exchangeable Cholesterol Pool in Man....Pages 305-308
Bile Acid Metabolism under Basal and Experimental Conditions in Normo- and Hyperlipidemic Subjects....Pages 308-311
Cholesterol Turnover and Metabolism in Normal and Hyperlipidemic Humans....Pages 311-314
Abstracts....Pages 315-321
Hormones, Lipoprotein Lipase and Atherosclerosis....Pages 322-322
Molecular Aspects of Hepatic Triglyceride Lipase and Lipoprotein Lipase from Human Post-Heparin Plasma....Pages 322-325
The Interactions of Lipoprotein Lipases with Cofactor Proteins Lipid Substrate, and Certain Sulfated Polysaccharides....Pages 325-328
Purified Monoacylglycerol Hydrolase from Human Post-Heparin Plasma: Characteristics and Role in the Reaction Catalyzed by Lipoprotein Lipase....Pages 328-332
Measurement of Post-Heparin Plasma Lipoprotein Lipase and Hepatic Triglyceride Lipase Activities and Their Relation to Plasma Triglyceride Metabolism....Pages 332-336
Hormonal Regulation of Human Adipose Tissue Lipoprotein Lipase....Pages 336-341
Post-Heparin Triglyceride Lipase Activity (PHTGLA) in Diabetic Rats....Pages 342-343
Abstracts....Pages 344-349
Influence of Muscular Training on Arterial Wall Cell Reaction....Pages 350-353
Complex Carbohydrates of Arterial Wall Connective Tissue....Pages 353-357
New Results on Gag and Collagen in Atherosclerosis....Pages 357-362
Functional Relations Among Cells and Fibers of the Aortic Media: Microanatomic and Biosynthetic Findings....Pages 362-365
Abstracts....Pages 366-373
Front Matter....Pages 375-375
Animal Models of Regression....Pages 377-385
Methods to Accelerate Regression....Pages 386-393
Front Matter....Pages 375-375
The Mechanism of Atherosclerosis Regression....Pages 394-404
Connective Tissue Changes in Regression....Pages 405-413
Angiographic Evidence of Atherosclerosis Regression in Man....Pages 414-421
Enhancement of Regression of Human Atherosclerosis....Pages 422-436
Influence of all Nutrients on Atherosclerosis....Pages 437-438
Influence of Diet Factors on Plasma Lipids in Ischemic Heart Disease....Pages 438-441
Practical Considerations of Changing Dietary Cholesterol and Fat....Pages 442-445
Dietary Protein, Hypercholesterolemia, and Atherosclerosis....Pages 445-448
Soybean Protein Diet in the Treatment of Hypercholesterolemia....Pages 448-453
Abstracts....Pages 454-457
Front Matter....Pages 459-459
Epidemiological Studies of Atherosclerotic Disease in Japan....Pages 461-470
Highlights of Epidemiological Research in Western Countries....Pages 471-478
Abstracts....Pages 479-485
Front Matter....Pages 487-487
Risk Factors in Children — The Early Natural History of Atherosclerosis....Pages 489-497
Morphologic Apsects of Childhood Atherosclerosis....Pages 498-505
Abstracts....Pages 506-508
Front Matter....Pages 509-509
Dietary Management of Atherosclerosis....Pages 511-516
Drugs and Atherosclerosis....Pages 517-527
Surgical Management of Hyperlipidemia....Pages 528-535
Metabolic Aspects of the Management of Obliterative Atherosclerosis....Pages 536-542
Front Matter....Pages 509-509
Abstracts....Pages 543-558
Mechanisms of Hyperlipoproteinaemia Derived from Multicompartmental Analysis of Very Low-Density Apolipoprotein B-Kinetics....Pages 559-562
On the Significance of Typing of Hyperlipoproteinemia in Primary Asymptomatic Hyperlipidemia....Pages 563-566
Secondary Causes and Aggravating Factors for Hyperlipoproteinemia....Pages 566-570
Diagnosis of Type III Hyperlipoproteinemia by Means of Rate Zonal Ultracentrifugation....Pages 570-573
Some Aspects of Sensitivity and Resistance to the Cholesterol Lowering Effect of Clofibrate....Pages 573-576
Newer Methods of Treatment of the Hyperlipoproteinemias....Pages 576-580
Analysis of the Characteristics of β-K Band in the Fraction of Lipoprotein by Polyacrylamide Gel-Disc Electrophoresis and the Frequency of its Appearance in IHD....Pages 580-583
Nutritional Factors and Atherosclerosis....Pages 583-588
Abstracts....Pages 589-593
Introduction....Pages 594-594
Structure of the Renal Artery and its Vasoconstriction....Pages 594-596
Coronary Arterial Changes in Childhood and Young Adults with Respect to Progression of Coronary Sclerosis and a Brief Comment on Thrombosis as a Complication....Pages 597-600
Thrombosis and Endothelial Injury in Atherogenesis....Pages 601-605
Platelet Factors and the Proliferation of Vascular Smooth Muscle Cells....Pages 605-609
Thrombogenic and Atherogenic Effects of Dietary Fats....Pages 609-612
Scanning and Transmission Electron Microscopic Studies on Experimental Thrombosis in Rabbits....Pages 613-616
Abstracts....Pages 617-623
Proliferative Response of Arterial Smooth Muscle Cells to Hyperlipemia....Pages 624-627
Cholesterol Ester Synthesis by Microsomal Fractions from Fu5AH RAT Hepatoma Cells: Stimulation by Lipoproteins from Hyperlipemic Sera....Pages 627-631
Front Matter....Pages 509-509
Inhibition of Lipid Synthesis by Sulfated Glycans in Cultured Aortic Cells....Pages 632-635
The Effect of Hypoxia and Carbon Monoxide on Arterial Smooth Muscle Cell Cultures....Pages 636-639
Sterol Metabolism in Cultured Human Endothelial Cells....Pages 639-642
Effect of Human Sera on DNA Synthesis in Aortic Explants....Pages 642-644
Abstracts....Pages 645-649
Introduction....Pages 650-650
Studies on the Atherogenesis and Sucrose Intake in Crab-Eating Monkeys....Pages 650-654
Ascorbic Acid and Atherosclerosis: Effects of Chronic Hypovitamin C on Aortic Ground Substance and Lipid Metabolism....Pages 654-658
Ethanol-Lipemia — A Doubtful Risk Factor....Pages 658-664
Vasoactive Agents and Postprandial Chylomicrons as Risk Factors in Atherogenesis....Pages 664-670
Unexplained Variability in Extent of Atherosclerosis in Homogeneous Human Populations....Pages 671-674
Abstract....Pages 675-675
Diet and Coronary Heart Disease — Primary Prevention Trials....Pages 676-679
Attempts at Primary and Secondary Prevention of Coronary Heart Disease....Pages 680-686
Intervention Trial for Secondary CV Prevention in Primary Atherogenous Hyperlipidemias....Pages 686-690
The Multiple Risk Factor Intervention Trial (MRFIT)....Pages 690-692
Back Matter....Pages 693-800