Assessment of the Use of Single Cytochrome P450 Enzymes in Drug Research

Front Matter....Pages I-XII
Xenobiotic Metabolism: From Intact Biosystem to Single Enzymes....Pages 1-19
Regulation of Xenobiotic-Metabolizing Cytochromes P450....Pages 21-42
Cytochrome P450 in Human Drug Metabolism: How Much Is Predictable?....Pages 43-56
Metabolic Activation of Anticancer Oxazaphosphorines by Cytochrome P450s: Development of a Model for Cancer Gene Therapy....Pages 57-80
The Use of Bacteria for Cytochrome P450 Expression....Pages 81-95
Expression of Cytochromes P450 in Yeast: Practical Aspects....Pages 97-110
Human Cells as an Expression System for Cytochromes P450....Pages 111-134
Metabolic Reactions and Recombinant Isoenzymes of Cytochrome P450: Information Generated and Value for Pharmaceutical Development....Pages 135-160
The Importance of Cytochrome P450 3A Enzymes in Drug Metabolism....Pages 161-186
Strategies for Verifying the Involvement of Specific Cytochrome P450 Enzymes in Xenobiotic Metabolism....Pages 187-194
Regulation of Cytochromes P450 by Substrate Interactions....Pages 195-211
Strategies for the Use of Single Cytochrome P450 Enzymes in Drug Research and Future Prospects....Pages 213-223
Back Matter....Pages 225-227