Artificial Organs: Proceedings of a seminar on the clinical applications of membrane oxygenators and sorbent-based systems in kidney and liver failure and drug overdose, held at the University of Strathclyde, Glasgow, in August, 1976

Front Matter....Pages i-xxviii
Opening Remarks and Welcome to Participants....Pages 1-2
Summary of The 1976 Adam Thomson Lecture: Progress and Prospects in Bioengineering....Pages 3-8
Front Matter....Pages 9-9
Membrane Oxygenation: An Overview....Pages 11-19
Sorbents in Therapeutic Medicine....Pages 20-26
Platelet Behaviour in Extracorporeal Circulation (ECC)....Pages 27-36
Front Matter....Pages 37-37
Mass Transfer Modelling for Membrane Oxygenators....Pages 39-49
Experimental Membrane Oxygenators with Convective Mixing for Gas Transfer Augmentation....Pages 50-60
A High-Performance Membrane Lung....Pages 61-69
The Taylor-Vortex Membrane Oxygenator....Pages 70-82
Total Long-Term Veno-Arterial Bypass by Ventricle Pump and Membrane Oxygenator....Pages 83-86
Clinical Reflections on Extracorporeal Membrane Oxygenation....Pages 87-88
The Corpuscular Volume Distribution of Erythrocytes during ECMO and after Exposure to Shear Forces....Pages 89-97
Supplementary Extracorporeal Oxygenation(SECO): Experimental Models....Pages 98-104
Role of Veno-Arterial Bypass on Natural Lung Oxygen Transfer during Long-Term Respiratory Assistance with Membrane Lung Oxygenator....Pages 105-111
An Experimental Model of Respiratory Insufficiency for Supplementary Extracorporeal Oxygenation....Pages 112-116
Front Matter....Pages 121-121
The Design of a Charcoal Haemoperfusion System....Pages 123-132
The Design of a Polymer Coating for Activated Carbon....Pages 133-138
The Role of Adsorbents in the Wearable Artificial Kidney....Pages 139-147
Evaluation of Haemoperfusion Systems: In Vitro Methods Related to Performance and Safety....Pages 148-157
Conversion of Creatinine in the Presence of Activated Carbon....Pages 158-163
Front Matter....Pages 121-121
Protective Effects of Microencapsulation (Coating) on Platelet Depletion and Particulate Embolism in the Clinical Applications of Charcoal Haemoperfusion....Pages 164-177
The Role of Charcoal Haemoperfusion in the Management of Acute Poisoning by Drugs....Pages 178-187
Clinical Application of Haemoperfusion in Uraemia....Pages 188-195
The Clinical Use of a Carbon Haemoperfusion Column....Pages 196-202
Haemoperfusion in the Treatment of Acute Poisoning....Pages 203-212
An Animal Model for Adsorbent Evaluation....Pages 213-219
Chronic Uraemia-Haemodialysis or Haemoperfusion?....Pages 220-226
Front Matter....Pages 233-233
Thrombogenesis Caused by Blood-Foreign Surface Interaction....Pages 235-247
Platelet-Foreign Surface Interactions with Oxygenator Membranes....Pages 248-262
Interaction of Platelets with Surfaces: A Factorial Study of Adhesion and Associated Release of Serotonin....Pages 263-272
Platelet-Protein Interactions: Role of Proteins in Platelet Aggregation and Adhesion....Pages 273-279
Haemostatic Changes Induced by Adsorbent Haemoperfusion....Pages 280-290
Selective Removal of Phosphate Ions from the Blood of Uraemic Patients....Pages 291-299
Adsorption of Barbiturates from Buffers, Blood and Intestinal Fluids....Pages 300-310
Dialysate Regeneration....Pages 311-318
An In Vitro Study of the Comparative Performance of Single and Double Needle Dialysis Systems....Pages 319-326
An Improved Oxystarch in the Treatment of Renal Failure....Pages 327-332
Oxidised Starch Plus Activated Charcoal in the Nephrectomised Rat and Uraemic Man....Pages 333-342
Front Matter....Pages 349-349
Animal Models of Hepatic Failure for Evaluation of Artificial Liver Support Techniques....Pages 351-362
Resin and Charcoal Haemoperfusion in the Treatment of Hepatic Coma....Pages 363-371
Front Matter....Pages 349-349
Hepatic Assist 1: Use of Liver Tissue in an Extracorporeal Device....Pages 372-377
Hepatic Assist 2: Devices for Use with Sorbents and Biological Reactors....Pages 378-387
Towards an Extracorporeal Detoxification System in Liver Failure. Detoxifying Enzymes Bound to Artificial Carriers as Mono-and Multi-enzyme Complexes....Pages 388-394
Hepatic Support System Utilising High-Porosity Protein-Permeable Membranes in Conjunction with Dialysate Regeneration....Pages 395-402
Approaches to the Development of Artificial Liver Support....Pages 403-412
Removal of Bilirubin from the Blood of Jaundiced Infants....Pages 413-424
Successful Management of Stage IV Hepatic Coma in a Child by Haemocarboperfusion....Pages 425-428
Front Matter....Pages 433-434
The Clinical Role of the Membrane Oxygenator....Pages 435-438
The Clinical Role of Adsorbents in Acute and Chronic Therapeutic Medicine....Pages 439-442
Thrombogenesis in Membrane Oxygenators and Adsorption Devices....Pages 443-445
Back Matter....Pages 447-450