Arterial Chemoreceptors in Physiology and Pathophysiology

Front Matter....Pages i-xi
Epigenetic Regulation of Carotid Body Oxygen Sensing: Clinical Implications....Pages 1-8
Experimental Observations on the Biological Significance of Hydrogen Sulfide in Carotid Body Chemoreception....Pages 9-16
The CamKKβ Inhibitor STO609 Causes Artefacts in Calcium Imaging and Selectively Inhibits BKCa in Mouse Carotid Body Type I Cells....Pages 17-24
Tissue Dynamics of the Carotid Body Under Chronic Hypoxia: A Computational Study....Pages 25-39
Paracrine Signaling in Glial-Like Type II Cells of the Rat Carotid Body....Pages 41-47
Selective mu and kappa Opioid Agonists Inhibit Voltage-Gated Ca2+ Entry in Isolated Neonatal Rat Carotid Body Type I Cells....Pages 49-54
Measurement of ROS Levels and Membrane Potential Dynamics in the Intact Carotid Body Ex Vivo....Pages 55-59
Acutely Administered Leptin Increases [Ca2+]i and BKCa Currents But Does Not Alter Chemosensory Behavior in Rat Carotid Body Type I Cells....Pages 61-67
Functional Properties of Mitochondria in the Type-1 Cell and Their Role in Oxygen Sensing....Pages 69-80
Potentiation of Hypoxic Pulmonary Vasoconstriction by Hydrogen Sulfide Precursors 3-Mercaptopyruvate and D-Cysteine Is Blocked by the Cystathionine γ Lyase Inhibitor Propargylglycine....Pages 81-87
Modulation of the LKB1-AMPK Signalling Pathway Underpins Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension....Pages 89-99
Organismal Responses to Hypoxemic Challenges....Pages 101-113
Effect of Lipopolysaccharide Exposure on Structure and Function of the Carotid Body in Newborn Rats....Pages 115-121
Hypoxic Ventilatory Reactivity in Experimental Diabetes....Pages 123-132
Adenosine Receptor Blockade by Caffeine Inhibits Carotid Sinus Nerve Chemosensory Activity in Chronic Intermittent Hypoxic Animals....Pages 133-137
Neurotrophic Properties, Chemosensory Responses and Neurogenic Niche of the Human Carotid Body....Pages 139-152
Is the Carotid Body a Metabolic Monitor?....Pages 153-159
Lipopolysaccharide-Induced Ionized Hypocalcemia and Acute Kidney Injury in Carotid Chemo/Baro-Denervated Rats....Pages 161-166
Role of the Carotid Body Chemoreflex in the Pathophysiology of Heart Failure: A Perspective from Animal Studies....Pages 167-185
A Short-Term Fasting in Neonates Induces Breathing Instability and Epigenetic Modification in the Carotid Body....Pages 187-193
Carotid Body Chemoreflex Mediates Intermittent Hypoxia-Induced Oxidative Stress in the Adrenal Medulla....Pages 195-199
The Association Between Antihypertensive Medication and Blood Pressure Control in Patients with Obstructive Sleep Apnea....Pages 201-209
An Overview on the Respiratory Stimulant Effects of Caffeine and Progesterone on Response to Hypoxia and Apnea Frequency in Developing Rats....Pages 211-220
Hyperbaric Oxygen Therapy Improves Glucose Homeostasis in Type 2 Diabetes Patients: A Likely Involvement of the Carotid Bodies....Pages 221-225
Possible Role of TRP Channels in Rat Glomus Cells....Pages 227-232
Nitric Oxide Deficit Is Part of the Maladaptive Paracrine-Autocrine Response of the Carotid Body to Intermittent Hypoxia in Sleep Apnea....Pages 233-237
Respiratory Control in the mdx Mouse Model of Duchenne Muscular Dystrophy....Pages 239-244
Mild Chronic Intermittent Hypoxia in Wistar Rats Evokes Significant Cardiovascular Pathophysiology but No Overt Changes in Carotid Body-Mediated Respiratory Responses....Pages 245-254
Crucial Role of the Carotid Body Chemoreceptors on the Development of High Arterial Blood Pressure During Chronic Intermittent Hypoxia....Pages 255-260
Relative Contribution of Nuclear and Membrane Progesterone Receptors in Respiratory Control....Pages 261-267
Inhibition of Protein Kinases AKT and ERK1/2 Reduce the Carotid Body Chemoreceptor Response to Hypoxia in Adult Rats....Pages 269-277
Ecto-5′-Nucleotidase, Adenosine and Transmembrane Adenylyl Cyclase Signalling Regulate Basal Carotid Body Chemoafferent Outflow and Establish the Sensitivity to Hypercapnia....Pages 279-289
T-Type Ca2+ Channel Regulation by CO: A Mechanism for Control of Cell Proliferation....Pages 291-300
Glutamatergic Receptor Activation in the Commisural Nucleus Tractus Solitarii (cNTS) Mediates Brain Glucose Retention (BGR) Response to Anoxic Carotid Chemoreceptor (CChr) Stimulation in Rats....Pages 301-308
Augmented 5-HT Secretion in Pulmonary Neuroepithelial Bodies from PHD1 Null Mice....Pages 309-313
Selective Expression of Galanin in Neuronal-Like Cells of the Human Carotid Body....Pages 315-323
Chronic Intermittent Hypoxia Blunts the Expression of Ventilatory Long Term Facilitation in Sleeping Rats....Pages 325-333
Heme Oxygenase-1 Influences Apoptosis via CO-mediated Inhibition of K+ Channels....Pages 335-342
Inhibition of T-type Ca2+ Channels by Hydrogen Sulfide....Pages 343-351
GAL-021 and GAL-160 are Efficacious in Rat Models of Obstructive and Central Sleep Apnea and Inhibit BKCa in Isolated Rat Carotid Body Glomus Cells....Pages 353-360
The Human Carotid Body Gene Expression and Function in Signaling of Hypoxia and Inflammation....Pages 361-370
The Carotid Body Does Not Mediate the Acute Ventilatory Effects of Leptin....Pages 371-377
Back Matter....Pages 379-385
....Pages 387-404